Welcome on Infostab

 

Infostab is a non-profit making association under French law. The goal of the association is to promote the correct use of injectable drugs in hospital (preparation, administration, stability and compatibility).

 

The association publishes an international database of stabilities and compatibilities of injectable drugs, STABILIS, which is translated into 24 languages.

 

Currently, the Web site is mainly directed towards the aspects of stability and compatibility of injectable drugs with topical information, lists of publications and posters as well as links towards guidelines concerning stability studies, the sites of other databases or journals publishing on the subject. 

 

Please send us any ideas for improving the site. 


The president of Infostab

Dr. Jean Vigneron


News

09/03/2010
LC stability studies of voriconazole and structural elucidation of its major degradation product
Adams, A.I.H., Gosmann, G., Schneider, P.H., Bergold, A.M..
Chromatographia Volume 69, Issue suppl. 2, June 2009, Pages S115-S122


05/03/2010
Chemical Stability of Hydrocortisone in Humco Simple Syrup and Ora-Sweet Vehicle
Vishnu D. Gupta,
International Journal of Pharmaceutical Compounding Vol. 14 No. 1 | January/February 2010


02/03/2010
Analysis of the stability and microbiological safety of aznol saline gargle in hospital preparations widely used for the treatment of oral cancer patients with oral mucositis
Ushiyama, M., Ikeda, R., Nitta, T., Tazitsu, Y., Miyawaki, A., Yamaguchi, T., Shimodouzono, Y., Ushinohama, K., Matsui, R., Sugihara, K., Nakamura, N., Yamada, K.
Oral Therapeutics and Pharmacology Volume 27, Issue 3, December 2008, Pages 143-150


26/02/2010
Stability of Mesna in ReadyMed Infusion Devices
Hassan Almoazen, Himanshu Bhattacharjee, Anthony C Samsa, and Steve Pate
Ann Pharmacother 2010;44:224-225


23/02/2010
Long-term stability of tramadol chlorhydrate and metoclopramide hydrochloride in dextrose 5% polyolefin bag at 4°C.
Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
J Oncol Pharm Practice 2009 ; 15: 195-200


19/02/2010
Concomitant administration of intravenous drugs in the ICU: evaluation of physico-chemical compatibilities.
Humbert-Delaloye V, Voirol P, Gattlen L, Berger M, Pannatier A.
Congress ESCP / GSASA, Geneva, 3-5 November 2009


16/02/2010
Stability of Mesna in ReadyMed Infusion Devices
Hassan Almoazen, Himanshu Bhattacharjee, Anthony C Samsa, and Steve Pate
Ann Pharmacother 2010;44:224-225


12/02/2010
Estabilidad del colirio de pilocarpina 2 %
Martha Botet García; Caridad Margarita García Peña; Vivian Martínez Espinosa; Bárbara Moreno Correoso.
Revista Cubana de Farmacia 2009 ; 43, 4 : 61-67


09/02/2010
Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.
Ilaria Tamaro, Silvio Aprile, Giovanni B. Giovenzana and Giorgio Grosa.
Journal of Pharmaceutical and Biomedical Analysis Volume 51, Issue 5, 6 April 2010, Pages 1024-1031


05/02/2010
Survey of Canadian Pharmacists’ Responses to Warnings of Potential Interactions Between Ceftriaxone and Calcium in IV Solutions.
Harder CK, Hawbolt JJ.
Can J Hosp Pharm 2009; 62, 6: 483-486


02/02/2010
Relevant shaking stress conditions for antibody preformulation development
Annette Eppler,  Markus Weigandt, Andrea Hanefeld and Heike Bunjes
European Journal of Pharmaceutics and Biopharmaceutics 2009


29/01/2010
Effect of freezing, long-term storage and microwave thawing on the stability of a mixture of diclofenac and sodium bicarbonate in glucose 5% polyolefin bags.
François JH, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
Ann Pharm Fr 2009; 67: 427-432


26/01/2010
Compatibility and stability of parenteral analgesic admixtures for multimodal analgesia 
David Balayssac,  Lise Badaroux,  Céline Rodier, Valérie Sautou-Miranda, Jean Etienne Bazin, Jean Chopineau.
EJHP Science 2009; 15, 4: 78-82


22/01/2010
Stability of preoperative cataract surgery gel in polycarbonate syringes.
Bailey C, Aloumanis V, Walker B, Ben M, Mc Guire J, Vu N.
Int J Pharm Compound 2009; 13, 6: 564-568


19/01/2010
Qualification of a microfluidics-based electrophoretic method for impurity testing of monoclonal antibodies 
Bernhard Antes, Philipp Oberkleiner, Andreas Nechansky, Oliver H.J. Szolar.
Journal of Pharmaceutical and Biomedical Analysis 2010; 51:  743–749


15/01/2010
Development and validation of a stability-indicating RP-HPLC method for assay of betamethasone and estimation of its related compounds.
Qiang Fu, Minshan Shou, Dwight Chien, Robert Markovich, Abu M. Rustum
Journal of Pharmaceutical and Biomedical Analysis 2010; 51:  617–625


12/01/2010
Compatibility of an injectable high strength oxycodone formulation with typical diluents, syringes, tubings, infusion bags and drugs for potential co-administration
Selina Hines, Steve Pleasance.
EJHP Practice 2009; 15, 5: 32-38


08/01/2010
Stabilité de solutions de bévacizumab en fonction de la température
Morand K, paul M, Lahlou A, Blanchet B, Astier A.
Service de Pharmacie-Toxicologie, APHP
UMR CNRS 7054
CHU Henri Mondor 94010 Cr CHU Henri Mondor 94010 Créteil
Poster presented at the SFPO Congress in October 2009 (French Society of Oncology Phamacists)
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



05/01/2010
Spironolactone oral suspension for paediatric use: preparation, stability study and clinical use.
Bersani G, Crivelli A, Mignini L, Stancari A, Guarguaglini AM, Pugiolli C, Rodriguez  L.
Bologna - Italy
33rd SIFO National Congress, Colli Del Tronto - Italy 2nd October 2009.
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



01/01/2010
Compatibilité entre amiodarone, catecholamines et/ou nitroprussiate de sodium,
administré en continu par voie veineuse aux soins intensifs adultes.
Imesch G., Humbert-Delaloye V., Berger M., Pannatier A.
GASA Congress Lucerne 2008

The Infostab team wishes you a Happy New Year 2010!



29/12/2009

Visible particulates in injections: A history and a proposal to revise USP General chapter injections
Russell E. Madsen, Roy T. Cherris, John G. Shabushnig, and Desmond G. Hunt
Pharmacopeil Forum 2009; 35, 5: 1383-1387

25/12/2009
The need for chemical compatibility studies of subcutaneous medication combinations used in palliative care.
Rose M, Currow DC.
J Pain Palliat Care Pharmacother. 2009 Sep;23(3):223-30


22/12/2009
Preparation of 0.05% FK506 suspension eyedrops and its pharmacokinetics after topical ocular administration.
Yuan J, Zhai JJ, Chen JQ, Ye CT, Zhou SY.
J Ocul Pharmacol Ther. 2009 Aug;25(4):345-50


18/12/2009
Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes.
Pascuet E, Donnelly RF, Garceau D, Vaillancourt R.
Can J Hosp Pharm 2009; 62, 5: 375-380


15/12/2009
The Infostab/Stabilis website: a tool for oncology pharmacists
Vigneron J.
EJOP 2009 ; 3, 2 : 12


11/12/2009
Evaluation of the stability of morphine sulphate in combination with Instillagel®. Abdelmageed R, Labyad N, Watson DG, Pournamdari M, Cable CG, Stanley E.
J Clin Pharm Ther 2009; 33, 3: 263-271


08/12/2009
Valutazione della stabilità chimico-fisica e microbiologica del collirio isotonico di voriconazolo.
S. Giorgi(1), A. D’arpino(2), C. La Rosa(3), R. Meucci(1), A. Garaffi(1), I. Corti(1), M.G. Rossetti(1) S. Giorgi(1), A. D’arpino(2), C. La Rosa(3), R. Meucci(1), A. Garaffi(1), I. Corti(1), M.G. Rossetti(1)
1.Area galenica U.O.C. Farmacia, Azienda Ospedaliera Senese - Siena; 1.Area galenica U.O.C. Farmacia, Azienda Ospedaliera Senese - Siena;
2. Assistenza Farmaceutica, azienda USL n. 4 -Terni; 2. Assistenza Farmaceutica, azienda USL n. 4 -Terni;
3.Farmaco Chimico tecnologico, facoltà di Farmacia Università di Siena – Siena.
This poster was presented at the last congress of the Italian Society of Hospital Pharmacists (SIFO) in october 2009. This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



04/12/2009
Anticorpi monoclonali: valutazione della stabilità microbiologica e chimico-fisica di preparazioni utilizzatez in ambito ospedaliero.
L. Bellante(1), F. Gasparrini(2), G. Guglielmi(1), E. M. Proli (1), L. Sabene(1), P. Simone (2), G. Viora(
1 Farmacia Ospedaliera, Policlinico Universitario A. Gemelli della U.C.S.C.-Roma (RM); 2 Dip. di Chimica e Tecnologie del Farmaco , Università degli studi “La Sapienza” -Roma (RM)
Poster presented at the last SIFO Congress (Italian Society of Hospital Pharmacists)
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



01/12/2009
Mechanically-induced aggregation of the monoclonal antibody cetuximab
A. Lahlou, B. Blanchet, M. Carvalho,M. Paul, A. Astier.
Annales Pharmaceutiques Françaises (2009)
This publication can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



27/11/2009
Evaluation of the Sterility, Stability, and Efficacy of Bevacizumab Stored in Multiple-Dose Vials for 6 Months
Yi-Hao Chen , Pei-Chang Wu, Jentaie Shiea, Li-Hua Lo, Yi-Chen Wu, Hsi-Kung Kuo.
Journal of Ocular Pharmacology and Therapeutics. February 2009, 25(1): 65-70


24/11/2009
Etude de la stabilité de la solution commerciale d'irinotécan (Campto®) après prélèvements réitérés dans la même flacon.
E. Huet, S. Roy, C. Hochart Hochart, A. Bellanger, R. Farinotti, , C. Fernandez
Laboratoire d’Analyse du médicament – Unité de Pharmacie Clinique Oncologique - Service de Pharmacie
GH Pitié-Salpêtrière.
Poster presented at the last Congress of the french Society of Hospital Pharmacists (SFPO) in October 2009
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



20/11/2009
Stabilité d'un anticorps monoclonal après reconstitution : le rituximab.
E. Jaccoulet, S. Guirao, K. Morand, A. Astier, M. Paul.
University Hospital of Créteil - France
This poster has been presented at the SFPO Congress in Cannes - France October 2009
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



17/11/2009
A validated stability-indicating RP-HPLC method for levofloxacin in the presence of degradation products, its process related impurities and identification of oxidative degradant
Devi L, Chandrasekar KB.
J Pharm Biomed Anal 2009 ; 50, 5 : 710-717


13/11/2009
Compatibility studies of acyclovir and lactose in physical mixtures
and commercial tablets
Farnaz Monajjemzadeh, Davoud Hassanzadeh , Hadi Valizadeh, Mohammad R. Siahi-Shadbad,
Javid Shahbazi Mojarrad, Thomas A. Robertson, Michael S. Roberts.
Eur J Pharm Biopharm 2009; 73: 404-413.


10/11/2009
Physicochemical stability of oxaliplatin in 5% dextrose injection stored in polyvinyl chloride, polyethylene, and polypropylene infusion bags
Eiden C, Philibert L, Bekhtari K, Poujol S, Malosse F, Frédéric Pinguet F.
American Journal of Health-System Pharmacy 2009;  66, 21: 1929-1933.



06/11/2009
Estabilidad del colirio de pilocarpina 2 %
Martha Botet GarcíaI; Caridad Margarita García EspinosaIII; Bárbara Moreno CorreosoIV .
Revista Cubana de Farmacia. 2009; 43, 4: 61-67.



16/10/2009
Stability of extemporaneously prepared voriconazole ophthalmic solution
Daoud Al-Badriyeh, Jian Li, Kay Stewart, David C. M. Kong, Lok Leung, Geoffrey E. Davies, and Robert Fullinfaw
Am J Health Syst Pharm 2009 66: 1478-1483


13/10/2009
Stability of docetaxel diluted to 0.3 or 0.9 mg/mL with 0.9% sodium chloride injection and stored in polyolefin or glass containers
Ana Aragones Eroles, Irene Mangues Bafalluy, and Joan Antoni Schoenenberger Arnaiz
Am J Health Syst Pharm 2009 66: 1565-1568


09/10/2009
Stability of an extemporaneous oral liquid aprepitant formulation
L. Lee Dupuis, Karen Lingertat-Walsh and Scott E. Walker
Support Care cancer 2009; 17: 701-706


06/10/2009
Stability of alemtuzumab in infusion-bags
M. Kupfer, G. Scriba and M. Hartmann
Pharmazie 2009; 64, 9: 622-623


02/10/2009
Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC–MS and development of stability-indicating method
Biljana Jocić, Mira Zečević, Ljiljana Živanović, Ana Protić, Milka Jadranin, Vlatka Vajs
J Pharm Biomed Anal 2009 ; 50, 4 : 622-629


29/09/2009
A comparison of the stability of doxorubicin and daunorubicin in solid state
J. Cielecka-Piontek, A. Jelińska, M. Zając, M. Sobczak, A. Bartold, I. Oszczapowicz
J Pharm Biomed Anal 2009; 50, 4: 576-579


25/09/2009
Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine
SV Mulgund, MS Phoujdar, SV Londhe, PS Mallade, TS Kulkarni, AS Deshpande, KS Jain
Ind J Pharm Sci 2009 ; 71, 1 : 35-40


22/09/2009
Étude de stabilité d’une solution de céfuroxime pour injection intracamérulaire
Bontemps C, Chataigner A, Sautou-Miranda V, Chopineau J.
This poster was presented at the Hopipharm Congress In France.
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



18/09/2009
Mechanically-induced aggregation of the monoclonal antibody cetuximab.
Lahlou A, Blanchet B, Carvalho M, Paul M, Astier A.
Annales Pharmaceutiques Françaises 2009; 67, 5: 340-352.


15/09/2009
Hydromorphone and Dipyrone in PCA PCA-devices devices: Is this still a therapy with Hydromorphone?
Simone Müller, Rainer Trittler, Rolf Schubert, Egid Strehl.
University of Freiburg.
2nd PharmSciFair, Nice, 09. Juni 2009
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



15/09/2009
Compatibility of levofloxacin injection and magnesium sulfate
Mark G. Klang
Am J Health Syst Pharm 2009 66: 1520


11/09/2009
Oxycodon-Metamizol in PCAPumpen- Kompatibel?
Simone Müller, Rainer Trittler, Rolf Schubert.
University of Freiburg
Wissenschaftlicher Kongress der ADKA, Darmstadt 05. Juni 2009.
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



08/09/2009
Impact of bulking agents on the stability of a lyophilized monoclonal antibody
Jeffrey D. Meyer, Rajiv Nayar, Mark Cornell Manning.
European Journal of Pharmaceutical Sciences 2009 ; 38, 1 : 29-38


04/09/2009
Stability of gabapentin 300-mg capsules repackaged in unit dose containers
Abhay Gupta, Anthony B. Ciavarella, Barry Rothman, Patrick J. Faustino, and Mansoor A. Khan
Am J Health Syst Pharm 2009 66: 1376-1380


04/09/2009
Morphin-Haloperidol-Mischungen in PCA-Pumpen - Kompatibel?
Rainer Trittler, Simone Müller, Mar Esteban
University of Freiburg
Wissenschaftlicher Kongress der ADKA, Darmstadt 05. Juni 2009
This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ».
With the authorization of the authors.



01/09/2009
Effect of freeze-thawing on the long-term stability of calcium levofolinate in 5% dextrose stored on polyolefin infusion bags.
Lebitasy M, Hecq J.D, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L.
J Clin Pharm Ther 2009 ; 34, 4 : 423-428


28/08/2009
Simultaneous quantification of water-soluble and fat-soluble vitamins in parenteral nutrition admixtures by HPLC-UV-MS/MS
Raphaël Vazquez, My-Dung Le Hoang, Jean Martin, Yasmine Ait Yahia, Hervé Graffard, François Guyon, Bernard Do
EJHP Science • Volume 15 • 2009 • Issue 2 • P. 28-35


25/08/2009
Incompatibility of imipenem–cilastatin and amoxicillin
Bertrand Pourroy, Emilie Milano Bausset, Audrey Boulamery, Laurence Gauthier Villano, and Diane Braguer
Am J Health Syst Pharm 2009 66: 1253-1254


21/08/2009
Test de compatibilités en laboratoire: Utilisation d'une méthode visuelle
Humbert-Delaloye V, Berger M, Pannatier A.
Congrès annuel de la GSASA, Lucerne, 20-21 novembre 2008.
Can be downloaded onthe website of the University Hospital of Lausanne – Switzerland


18/08/2009
Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine
Mulgund S V, Phoujdar M S, Londhe S V, Mallade P S, Kulkarni T S, Deshpande A S, Jain K S.
Ind J Pharm Sci 2009; 781, 1: 35-40


14/08/2009
Schmerzmittelreservoire : Stabilität binärer Opioid-Metamizol-Mischungen
Simone Müller, Rainer Trittler, Herbert Bochow, Rolf Schubert, Egid Strehl
University of Freiburg
Der Deutsche Schmerz- und Palliativtag 2008, Frankfurt am Main 06. – 08. März 2008
This poster can be downloaded in "Publications" and "Stability and compatibility"
With the permission of the authors


11/08/2009
One-year follow-up on procedure to prevent i.v. drug incompatibilities in an intensive care unit
Thilo Bertsche, Linda Münk, Yvonne Mayer, Rebekka Stahl, Torsten Hoppe-Tichy, Jens Encke, and Walter Emil Haefeli
Am J Health Syst Pharm 2009 66: 1250-1253


07/08/2009
Morphin-Metamizol-Mischungen zur kontinuierlichen parenteralen Applikation:
Sind sie immer inkompatibel?
Simone Müller1, Rainer Trittler1, Rolf Schubert2, Wilhelm Freiherr von Hornstein3, Egid Strehl1
University of Freiburg - Germany
Poster presented at the ADKA Congress in May 2006
The poster can be downloaded in "Publication" and ""Stability and compatibility"


04/08/2009
Compatibilités entre amiodarone, cathécholamines et/ou nitroprussiate de sodium, administrés en continu par voie veineuses aux soins intensifs adultes.
Imesch G, Humbert-Delaloye V, Berger M, Pannatier A.
Congrès annuel de la GSASA, Lucerne, 20-21 novembre 2008.
Can be downloaded on the website of the University Hospital of Lausanne – Switzerland


31/07/2009
Stability of Low-concentration ceftazidime in 0.9% sodium chloride injection and balanced salt solutions in plastic syringes under various storage conditions.
Xu M, Warren F.W, Bartlett M.G.
Int J Pharm Compound 2009; 13, 2: 166-169


28/07/2009
The stability of biapenem and structural identification of impurities in aqueous solution
Ming Xia, Tai-Jun Hang, Fei Zhang, Xiao-Min Li and Xiang-Yang Xu
Journal of Pharmaceutical and Biomedical Analysis 2009 ; 49, 4 : 937-944


24/07/2009
Step nonisothermal method to study stability of drugs
Bing Lin   Xian-Cheng Zhan ;  Jian-Lin Tao ;  Lin-Li Li ; Hai-Jun Qi
Drug Development and Industrial Pharmacy, Volume 35, Issue 2 February 2009, pages 154 - 164


21/07/2009
Information for hospital wards about the compatibility of parenteral drugs
M C van Staveren; A Wieringa; T Visser
EJHP Practice 2009; 15, 1; 64- 64


17/07/2009
Lipid globule size in total nutrient admixtures prepared in three-chamber plastic bags
David F. Driscoll, Andrea Thoma, Rolf Franke, Karsten Klütsch, Jörg Nehne and Bruce R. Bistrian
American Journal of Health-System Pharmacy, Vol. 66, Issue 7, 649-656


14/07/2009
Stability of 5-fluorouracil and sodium folinate admixture
Cadrobbi J, Hecq J.D, Vanbeckbergen D, Jamart J, Galanti L.
Hospital Pharmacy Europe 2009 ; 42 : 30-31


10/07/2009
Evaluation of non-isothermal methods in stability studies of human insulin pharmaceutical preparations
Alexis Oliva, Marta Suárez, Juan Ramón Hernández, Matías Llabrés  and José B. Fariña
Journal of Pharmaceutical and Biomedical Analysis 2009 ; 49, 4:  916-922


07/07/2009
Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and ketamine in infusion solutions.
Hamdi M; Lentschener C; Bazin C; Ozier Y; Havard L.
European Journal of Anaesthesiology 2009; 26, 1: 23-27


03/07/2009
Development and validation of a stability-indicating RP-HPLC method to separate low levels of dexamethasone and other related compounds from betamethasone
Yuan Xiong, Kang Ping Xiao and Abu M. Rustum
Journal of Pharmaceutical and Biomedical Analysis ; 49, 3 : 646-654


30/06/2009
Kétamine : Etude de stabilité d'une solution aqueuse buvable à 1 mg/ml.
DUCHENE Marie-Laure*, DAURENJOU Magali*, LAVRUT Thibaut**, CARLES Danièle***, ALBERGE M.Claire****,
LEONARDO Sandrine*, PEROUX Eliane*
*Laboratoire de fabrication Pharmacie centrale, **Laboratoire de pharmacologie,***Laboratoire de bactériologie, ****Service de chirurgie
infantile ; C.H.U. de Nice
Poster presented during the last Synprefh Congress in Marseille - France -  May 2009
The poster can be downloaded. See in the menu "Publications" and "Stability and compatibility"
With the permission of the authors.


26/06/2009
Chemical Stability of Teniposide in Aqueous and Parenteral Lipid Emulsions
Jing Wang ;  Yue Cui ; Xing Tang
Drug Development and Industrial Pharmacy, Volume 35, Issue 4 April 2009 , pages 508 - 513



23/06/2009
Drug compatibility with a new generation of VISIV polyolefin infusion solution containers.
Aloumanis V, Ben M, Kupiec T.C, Trissel L.A.
Int J Pharm Compound 2009; 13, 2: 162-165


19/06/2009
Stability of fentanyl 5 µg/mL diluted with 0.9% sodium chloride injection and stored in polypropylene syringes
McCluskey S.V, Graner K.K, Kemp J, Aloumanis V, Ben M, Kupiec T, Nicole Vu N.
American Journal of Health-System Pharmacy,2009;  Vol. 66, Issue 9, 860-863


16/06/2009
Stability of Hydromorphone–Ketamine Solutions in Glass Bottles, Plastic Syringes, and IV Bags for Pediatric Use
Ensom M.H.H, Decarie D, Leung K, MontgomeryC
Can J Hosp Pharm 2009; 62, 2: 112-118


12/06/2009
Visual compatibility of i.v. medications routinely used in bone marrow transplant recipients
Canann D, Tyler L.S, Barker B, Condie C.
American Journal of Health-System Pharmacy, Vol. 66, Issue 8, 727-729


09/06/2009
Notice to Hospitals regarding Ceftriaxone–Calcium incompatibility: what’s a clinician to do?
Gin A, Walker S.
Can J Hosp Pharm 2009; 62, 2: 157-158



05/06/2009
Smart-pumps in the neonatal and pediatric intensive care unit: drug incompatibilities and occlusion alarms
C. Fonzo-Christe , A. Kiener MSc, N. Bochaton Nurse, P. Regard Engineer, P. Rimensberger ,P. Bonnabry.
This poster was presented at the ESCP / ACCP Congress in Orlando April 2009. It can be downloaded on the website of the University Hospital of Geneva



02/06/2009
Etude de stabilité du céfuroxime dansune solution d'irrigation oculaire
Peynaud D, Poy L, Goujon P, Jolivet A, Leboucher G.
University Hospital Lyon - France
This poster was presented during the XII Congress of the French Society of Clinical Pharmacy. Saint-Malo FRANCE February 2008
It can be downloaded in the menu publications" and "Stability and compatibility"
With the autorization of the authors.


29/05/2009
Extended Stability of Pantoprazole for Injection in 0.9% Sodium Chloride or 5% Dextrose at 4°C and 23°C
Scott E Walker, John Iazzetta, Shirley Law
Can J Hosp Pharm 2009; 62, 2: 135-141


26/05/2009
Physical Compatibility and Chemical Stability of Ketamine–Morphine Mixtures in Polypropylene Syringes
Ronald F Donnelly
Can J Hosp Pharm 2009; 62(1): 28–33


22/05/2009
Long-term stability of an aqueous solution containing lidocaine hydrochloride, dexamethasone sodium phosphate and adrenaline hydrochloride for electromotive administration.
Vonbach P, Angelika H, Dibied A
EJHP Science 2009; 15, 1: 6-10


19/05/2009
Information for hospital wards about the compatibility of parenteral drugs.
Van Staveren M.C, Wieringa A, Visser T
EJHP Practice 2009; 15, 1: 64


15/05/2009
The effect of nimodipine, fentanyl and remifentanil intravenous products on the stability of propofol emulsions
Nemec K, Germ E, Schulz-Siegmund M, Ortner A.
Pharmazie 2009; 64, 2: 94-97


12/05/2009
Stability of oxaliplatin solution
Audrey Junker, Sandrine Roy, Marie-Catherine Desroches, Clotilde Moussay, Malik Berhoune, Agnès Bellanger, Christine Fernandez, and Robert Farinotti
Ann Pharmacother 2009;43:390-391


08/05/2009
Stability of antineoplastic agents in use for home-based intravenous chemotherapy.
Frédéric Benizri, Brigitte Bonan, Anne-Laure Ferrio, Marie-Laure Brandely, Vincent Castagné, Nathalie Théou-Anton, Muriel Verlinde-Carvalho and Laurent Havard
Pharmacy World & Science 2009 Volume 31, Number 1: 1-13


05/05/2009
Stability of cyclosporine eye drops
Cécile Bontemps, Amandine Rougeron, Valérie Sautou-Miranda, Anne Boyer, Jean Chopineau.
Poster presented at ESCP Congress Dubrovnik, Croatia 21 -24 October 2008
The poster can be downloaded. See in "Publications" and "Stability and compatibility"
With the authorization of the authors.


01/05/2009
Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration
Laurence Galanti, Massin P Lebitasy, Jean-Daniel Hecq, Julie Cadrobbi, Danielle Vanbeckbergen, and Jacques Jamart
Can J Hosp Pharm 2009; 62(1): 34–38


28/04/2009
Chemical stability of a solution of bupivacaine hydrochloride 0.125% and sufentanil citrate 0.5 µg/ml for filling syringes using a repeater pump.
Janssen K, Wisselo R, Geerlings C, Schouten J.P.
EJHP Science 2009; 15, 1: 11-14


24/04/2009
Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application
Treleano A, Wolz G, Brandsch R, Welle F.
International Journal of Pharmaceutics (2009), Volume 369, Issues 1-2, Pages 30-37


21/04/2009
In vitro stability of enoxaparin solutions (20 mg/mL) diluted in 4% glucose
Rahul P. Patel, Christian Narkowicz, Glenn A. Jacobson
Clinical Therapeutics, Volume 30, Issue 10, October 2008, Pages 1880-1885


17/04/2009
Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing
Tze-Ming Chan, Birendra Pramanik, Robert Aslanian, Vincent Gullo, Mahesh Patel,
Bart Cronin, Chris Boyce, Kevin McCormick, Mike Berlin, Xiaohong Zhu, Alexei Buevich,
Larry Heimark, Peter Bartner, Guodong Chen, Haiyan Pu, Vinod Hegde.
Journal of Pharmaceutical and Biomedical Analysis 49 (2009) 327–332


14/04/2009
Development and stability testing of a concentrated injectable clonidine solution for intrathecal analgesia.
Hollenwaeger M, Borquin Challandes I, Fallab L.C, Schaad N, Zelger G.
EJHP Science 2008; 15, 1: 3-5


10/04/2009
Drug incompatibility chemistry
David W. Newton
Am J Health Syst Pharm 2009 66: 348-357


07/04/2009
Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate.
Cadrobbi J, Hecq J.D, Vanbeckbergen D, Jamart J, Galanti L.
EJHP Science 2009; 15, 1: 15-19


03/04/2009
Compatibility and stability of analgesic admixtures for parenteral use: paracetamol, ketoprofen and tramadol.
Lise Badaroux, Céline Rodier, David Balayssac ,Valérie Sautou-Miranda, Jean Chopineau
CHU Gabriel Montpied, Clermont-Ferrand, France
This poster was presented at the ESCP Congress in Edinburgh May 2007
Can be downloaded in "Publication" and "Stability and compatibility"
With the permission of the authors


31/03/2009
In vitro stability of lyophilized and reconstituted recombinant activated factor VII formulated for storage at room temperature
Hanne Nedergaard, Susanne Vestergaard, Pernille Theil Jensen, Morten Wagner Kristiansen, Michael Bech Jensen, Per B. Østergaard, Tina Norsell, Jens Bjerre
Clinical Therapeutics, Volume 30, Issue 7, July 2008, Pages 1309-1315


27/03/2009
Determination of impurities in heparin by capillary electrophoresis using high molarity phosphate buffers
Todd Wielgos,  Karalyn Havel, Nadia Ivanova, RobertWeinberger.
Journal of Pharmaceutical and Biomedical Analysis 49 (2009) 319–326


24/03/2009
In vitro stability of two formulations of recombinant activated factor viia reconstituted in inappropriate solvents or at inappropriate volumes
Britt Petersson, Anna B. Schönwandt, Preben Þstfeldt, Hanne Nedergaard, Michael Bech Jensen, Per B. Þstergaard, Tina Norsell, Jens Bjerre
Clinical Therapeutics, Volume 30, Issue 5, May 2008, Pages 917-923


20/03/2009
Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion.
Kambia N.K, Luyckx M, Dine T, Dupin-Spriet T, Gressier B, Brunet C.
Journal of Clinical Pharmacy and Therapeutics (2009) 34, 25–31


17/03/2009
Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride
Ch. Bharathi, P. Jayaram, Joseph Sunder Raj , M. Saravana Kumar, V. Bhargavi ,
V.K. Handa, Ramesh Dandala, A. Naidu.
Journal of Pharmaceutical and Biomedical Analysis 48 (2008) 1211–1218


13/03/2009
Précipitation du phosphate de calcium dans les nutritions parentérales : avantages des sels organiques
Bouchoud Bertholet L, Sadeghipour F, Fonzo-Christe C, Bonnabry P
Congrès GSASA, Lucerne, 20-21.11.2008
Can be downloaded on the website of University Hospital of Geneva


10/03/2009
Long term physico-chemical stability of standard parenteral nutrition for neonates
Bouchoud Bertholet L, Sadeghipour F, Fonzo-Christe C, Pfister R, Bonnabry P
30th Espen Congress, Florence 2008
Can be downloaded on the website of University Hospital of Geneva


06/03/2009
Release of a plasticizer. tri-2-ethylhexyl trimellitate from polyvinylchloride tubings
Sophie Trevis. Valérie Sautou-Miranda. Sandrine Bagel-Boithias. David Balayssac. Jean Chopineau.
This poster was presented at the ESCP Congress in Edinburgh mai 2007
See in the menu "Publication" and "Stability and compatibility" to download the poster.



03/03/2009
Stability and compatibility of drug mixtures in an implantable infusion system.
Bianchi F, Ginggen A, Tardy Y.
Anaesthesia. 2008 Sep;63(9):972-8


27/02/2009
Guidelines for stability testing of pharmaceutical products containing well established drug substances in conventional dosage forms.
This document can be downloaded on the website of WHO World Health Organization


24/02/2009
Stability testing of pharmaceutical products in a global environnement.
Sabine Kopp
This document can be downloaded on the website of WHO World Health Organization


20/02/2009
Tableau des médicaments photosensibles.
This document can be downloaded on the website of University Hospital of Geneva


17/02/2009
Influence de la lumière sur la stabilité des médicaments
This document can be downloaded on the website of University Hospital of Geneva


13/02/2009
Incidents de perfusion aux soins intensifs de pédiatrie : existe-t-il un lien entre les alarmes d'occlusion et des incompatibilités médicamenteuses ?
Amalys Kiener
This document can be downloaded on the website of University Hospital of Geneva


10/02/2009
Stabilité des formulations injectables de lidocaïne en présence de bicarbonate de sodium : mise en place d'une procédure pour les unités de soins.
Fleury Souverain S, De Giorgi I, Evard T, Bonnabry P
Congrès GSASA & 14èmes JFSPH, Lausanne, 14-16 novembre 2007
Can be downloaded on the website of University Hospital of Geneva


06/02/2009
Release of di(2-ethylhexyl)phtalate from polyvinylchloride bags during docetaxel infusions
Sandra BOURLON (1), Valérie SAUTOU-MIRANDA (1,2), Murielle DALLE (1),
David BALAYSSAC (1), Jean CHOPINEAU (1,2)
(1) Department of Pharmacy, G. Montpied Hospital, Clermont-Ferrand, France
Poster presented at the ESCP Congress in STockholm 2005
Can be downloaded in "Publications" and "Stability and compatibilities"


03/02/2009
Comparative evaluation of eight tools to prevent drug incompatibilities
De Giorgi I, Guignard B, Fonzo-Christe C, Bonnabry P
37th ESCP Congress, Dubrovnik, 22-24.10.2008
Can be downloaded on the website of University Hospital of Geneva


30/01/2009
Chemical stability of admixtures containing ziconotide 25 mcg/ml and morphine sulfate 10 mg/ml or 20 mg/ml during simulated intrathecal administration.
Shields D.E, Aclan J, Szatkowski A.
Int J Pharm Compound 2008 ; 12, 6: 553-557


27/01/2009
Physical compatibility and chemical stability of a concentrated solution of atropine sulfate (2 mg/ml) for use as an antidote in nerve agent casualties.
Donnelly R.F, Corman C.
Int J Pharm Compound 2008 ; 11, 6: 550-552


23/01/2009
Isolation and characterization of degradation impurities in epirubicin hydrochloride injection.
Kumar D, Tomar RS, Deolia SK, Srivastava R, Mitra M, Tyagi S.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 ; 15, 869(1-2):45-53


20/01/2009
Allestimento di farmaci oncologici: problemi di stabilità pratici e clinici

Angelo C. Palozzo, Alberto Marchi

Bollettino SIFO 208 ; 54, 2



16/01/2009
Allen LV, Okele CC.
Basics of compounding : Considerations for implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding – Sterile preparations, part 8: Stability and Beyond-Use dating.
Int J Pharm Compound 2008; 12, 4: 344-353


13/01/2009
Stabilité des formulations injectables de lidocaïne en présence de bicarbonate de sodium : mise en place d'une procédure pour les unités de soins
Fleury Souverain S, De Giorgi I, Evard T, Bonnabry P
Congrès GSASA & 14èmes JFSPH, Lausanne, 14-16 novembre 2007
This document can be downloaded on the website of the Pharmacy of the University  Hospital of Geneva –Switzerland


09/01/2009
Development of ready-to-use ketamine hydrochloride syringes for safe use in post-operative pain.
Stucki MC, Leury-Souverain S, Sautter AM, Sadeghipour F, Bonnabry P.
EJHP Science 2008; 14, 1: 14-18


05/01/2009
Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles
Brustugun J, Lao YE, Fagernæs C, Brænden J, Kristensen S.
Am J Health Syst Pharm 2009 66: 1722-1725


02/01/2009
Stability of Magnesium Sulfate 20% in Viaflex Bags
Brandi D Newby, Cindy Benes, Lynne Palmer, and Richard Cleve
Can J Hosp,Pharm 2008; 61, 5


30/12/2008
Durée de stabilité de médicaments en seringue pour administration sous-cutanée à des patients en fin de vie à domicile.
Annie Roberge, Julie Couture, Michel Tassé, Myreille Goulet, Robert Thiffault, Manon Hanna, Chantal Tremblay, Michèle Plante, Brigite Naud, Pierre-Richard Couture
Pharmactuel 2008 ; 41, 4 : 230-236



26/12/2008
Evaluation of the stability of gentamicin in different antibiotic carriers using a validated MEKC method.
K.-D. Kühnb, C. Webera, S. Kreisb, U. Holzgrabea
Journal of Pharmaceutical and Biomedical Analysis 2008; 48:  612–618


23/12/2008
Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances.
Yimei Baob, Xiaopeng Mob, Xiaoying Xub, Yuyu Heb, Xiao Xua, Haoyun Ana.
Journal of Pharmaceutical and Biomedical Analysis 2008; 48: 664–671


19/12/2008
Stability of alprostadyl solution in polypropylene syringes
This poster was presented during the APHIF Congress in November 2008
KACEM Balsam, CARVALHO Muriel,  LAHLOU Amine, GAUDOIN Anne, YIOU René, ASTIER Alain, PAUL Muriel.
University Hospital of Créteil – France
The poster can be freely downloaded. See in « Publications » and « Stability and compatibility »



16/12/2008
Cefepime Stability in IV Solutions and Admixtures
Christianne M Zaki, Nagia N Afifi, and Hanaa Aba El Moneim
Can J Hosp,Pharm 2008; 61, 5


12/12/2008
Short-term physical compatibility of intramuscular aripiprazole with intramuscular lorazepam
Lawrence J. Kovalick, Andrei A. Pikalov, III, Nina Ni, Vijay H. Naringrekar, and Robert D. McQuade
Am J Health Syst Pharm 2008 65: 2007-2008


09/12/2008
Chemistry and safety of phosphates injections
David W. Newton and David F. Driscoll
Am J Health Syst Pharm 2008 65: 1761-1766


05/12/2008
Bevacizumab Sterility in Multiple Doses from a Single-Use Vial
Kemal Örnek, Zeynep Ceren Karahan, Ahmet Ergin, Alper Tekeli, Oya Tekeli.
The Annals of Pharmacotherapy:2008; 42, 10, 1425-1428.



02/12/2008
Compatibility and Aerosol Characteristics of Formoterol Fumarate Mixed with Other Nebulizing Solutions
Samuel Akapo, June Gupta, Eloisa Martinez, Chithra McCrea, Liwen Ye, Mark Roach.
The Annals of Pharmacotherapy: 2008; 42, 10:1416-1424.



28/11/2008
Nutrition parentérale et médicaments intraveineux : enquête transversale sur les modes d’administration et recherche d’incompatibilités au CHU de Nancy
C. Steckmeyera, A. Giesenfeldb, O. Zieglerc and D. Quilliotd
Nutrition Clinique et Métabolisme, Volume 21, Supplement 2, November 2007, Pages 49-50



25/11/2008
Dégradation de la vitamine C dans différents sets d’administration de nutrition parentérale totale
Y.-M. Dupertuisa, A. Morchb, M. Kossovskyc, M. Fathib and C. Picharda
Nutrition Clinique et Métabolisme, Volume 21, Supplement 2, November 2007, Page 49



21/11/2008
Prevention of intravenous drug incompatibilities in an intensive care unit
Thilo Bertsche, Yvonne Mayer, Rebekka Stahl, Torsten Hoppe-Tichy, Jens Encke and Walter Emil Haefeli
American Journal of Health-System Pharmacy,2008;  Vol. 65, Issue 19, 1834-1840


18/11/2008
Handbook of injectable drugs 15th edition is now available. The database contains 359 drugs and 2723 references, 100 new to this edition.
Can be ordered on ASHP website



14/11/2008
Information about the stability of oncology drugs: the hospital pharmacist’s role.
J Vigneron.
EJHP – ESMO Supplement 2008 : 15-17.


07/11/2008
Physical and chemical stability of palonosetron hydrochloride with glycopyrrolate and neostigmine during simulated Y-site administration.
Ben M, Trusley C, Kupiec TC, Trissel LA.
Int J Pharm Compound 2008. 12, 4: 368-371.


04/11/2008
Standardization of infusion solutions to reduce the risk of incompatibility
Karin Nemec, Hannelore Kopelent-Frank and Robert Greif
American Journal of Health-System Pharmacy, Vol. 65, Issue 17, 1648-1654



31/10/2008
Chemical stability of admixtures combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration.
Shields DE, Aclan J, Szatkowski A.
Int J Pharm Compound 2008 ; 12, 5: 463-466.


28/10/2008
Stability of proteins in aqueous solution and solid state
S Jacob, AA Shirwaikar, KK Srinivasan, J Alex, SL Prabu, R Mahalaxmi, Ravi Kumar
Ind J Pharm Sci 2006; 68, 2: 154-163.



24/10/2008
Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients
Stephanie J. Wallace, Jian Li, ,  Craig. R. Rayner,  Kingsley Coulthard,and Roger L. Nation,
Antimicrobial Agents Chemother, 2008; 52, 98:  3047-3051.



21/10/2008
Compatibility and stability of palonosetron hydrochloride with lactated Ringer's, Hetastarch in lactated electrolyte, an mannitol injections during simulated Y-site administration.
Ben M, Kupiec T, Trusley C, Trissel LA.
Int J Pharm Compound 2008 ; 12, 5: 460-462.



17/10/2008
Prevention of intravenous drug incompatibilities in an intensive care unit
Thilo Bertsche, Yvonne Mayer, Rebekka Stahl, Torsten Hoppe-Tichy, Jens Encke and Walter Emil Haefeli
American Journal of Health-System Pharmacy,2008;  Vol. 65, Issue 19, 1834-1840



14/10/2008
Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration
Thomas C. Kupie, Craig Trusley, Michel Ben and Lawrence A. Trissel
American Journal of Health-System Pharmacy 2008, Vol. 65, Issue 18, 1735-1759



10/10/2008
McLellan C, Ngo V, Pasedis S, Dohlman CH.
Testing the tong term stability of vancomycin ophtalmic solution.
Int J Pharm Compound 2008 ; 12, 5: 456-459.



07/10/2008
Drug safety, drug quality, drug analysis
Sándor Görög
J Pharm Biomed Anal 2008 ; 48 : 247-253.



03/10/2008
Physical and Chemical Stability of Esomeprazole Sodium Solutions
Thomas C Kupiec, Vasileios Aloumanis,  Michel Ben, Lawrence A Trissel, Pak Chan, Joe Patterson.
The Annals of Pharmacotherapy: 2008 Vol. 42, No. 9, pp. 1247-1251




30/09/2008
Compatibility of anticancer drug solutions with administering devices.
Astier A.
EJHP – ESMO Supplement 2008 : 20-22.



26/09/2008
Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol
Hanna Kumpulainen, Tomi Järvinen, Anne Mannila, Jukka Leppänen, Tapio Nevalainen, Antti Mäntylä, Jouko Vepsäläinen and Jarkko Rautio
European Journal of Pharmaceutical Sciences Volume 34, Issues 2-3, 3 July 2008, Pages 110-117



23/09/2008
Stability of metoprolol tartrate injection 1 mg/mL undiluted and 0.5 mg/mL in 0.9% sodium chloride injection and 5% dextrose injection.
Kraft MD, Johnson CE, Chung C, Julian F
Am J Health Syst Pharm. 2008 Apr 1;65(7):636-8



19/09/2008
Physical and Chemical Stability of Esomeprazole Sodium Solutions (September)
Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, Lawrence A Trissel Pak Chan, Joe Patterson.
Ann. Pharmacother., Jul 2008



16/09/2008
Anti-Xa stability of diluted dalteparin for pediatric use.
Goldenberg NA, Jacobson L, Hathaway H, Tripputi M, Primeaux J, Child J
Ann Pharmacother. 2008 Apr;42(4):511-5. Epub 2008 Mar 18.



12/09/2008
Compatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administration
Pak Chan, Amanda Bishop, Thomas C. Kupiec, Lawrence A. Trissel, Dilip Gole, Ilias M. Jimidar and Hans Vermeersch
 American Journal of Health-System Pharmacy, Vol. 65, Issue 16, 1545-1551



09/09/2008
Chemical Stability of Admixtures Combining Ziconotide With Baclofen During Simulated Intrathecal Administration
David Shields, Rick Montenegro, Jennifer Aclan
Neuromodulation 2007 ; 10 : 12-17.



05/09/2008
Statistical Evaluation of the Chemical Stability of Ziconotide Solutions During Simulated Intrathecal Administration
David E. Shields PhD, Wei Liu PhD,  Kevin Gunning BA and Rick Montenegro.
Journal of Pain and Symptom Management 2008;36, Issue 1: e4-e6 



29/08/2008
Compatibility of doripenem with other drugs during simulated Y-site administration
Matthew K. Brammer, Pak Chan, Kathy Heatherly, Craig Trusley, Thomas C. Kupiec, Lawrence A. Trissel, Petros A. Psathas, Timothy Gilmor and Daniel Schaufelberger
American Journal of Health-System Pharmacy 2008, Vol. 65, Issue 13, 1261-1265



26/08/2008
Stabilité et compatibilité de l’association ondansétron–méthylprednisolone en solution
Christine Fernandez, Anne Pelloquin, Malik Berthoume, Agnes Bellanger et Robert Farinotti
Can J Hosp Pharm 2008 ; 61, 3 .



22/08/2008
Stability and Analgesic Efficacy of Di-acetyl Morphine (Diamorphine) Compared with Morphine in Implanted Intrathecal Pumps In Vivo
Jon H. Raphael, MD; Stephen M. Palfrey, MCB; Arasu Rayen, FRCA; Jane L. Southall, RN; Maurad H. Labib, FRCPath
Neuromodulation 2004 ; 7, 3 : 197-200.



19/08/2008
Lipid emulsions: alone or an all-in-one mixture
Marko Puzovic
EJHP Practice  2008; 2: 82 –84.



15/08/2008
Insulin temperature and stability under simulated transit conditions
Chris Chandler, Connie M. Gryniewicz, Tom Pringle and Fran Cunningham
American Journal of Health-System Pharmacy 2008, Vol. 65, Issue 10, 953-963



12/08/2008
Chemical Stability of Admixtures Combining Ziconotide with Morphine or Hydromorphone During Simul ated Intrathecal Administration
David Shields, PhD Rick Montenegro, BS Matthew Ragusa, BA
Neuromodulation 2005 ; 8, 4 : 257-263.



08/08/2008
Evaluation of the stability of morphine sulphate in combination with Instillagel®
R. Abdelmageed , N. Labyad , D. G. Watson, M. Pournamdari, C. G. Cable E. Stanley.
J Clin Pharm Ther 2008; 33, 3: 263-271.



05/08/2008
A new poster on the stability of oxaliplatine is available. See "Publications" and "Stability and compatibility" to download the document.


01/08/2008
Stability of lyophilized human growth hormone
Maya S. Salnikova, C. Russell Middaugh, J. Howard Rytting
Int J Pharm 2008; 358, 1-2 : 108-113

29/07/2008
Chemical Stability of Ziconotide-Clonidine Hydrochloride Admixtures With and Without Morphine Sulfate During Simulated Intrathecal Administration
David Shields, Rick Montenegro
Neuromodulation 2007 ; 10 : 6-11.

25/07/2008
Design and utilization of the drug–excipient chemical compatibility automated system
V. Hayden Thomas  Maryanne Naath
International Journal of Pharmaceutics 2008,Volume 359, Issues 1-2:150-157





22/07/2008
Chemical Stability of an Admixture Combining Ziconotide and Bupivacaine During Simulated Intrathecal Administration
David Shields, Rick Montenegro, Jennifer Aclan
Neuromodulation 2007 ; 10 : 1-5.



18/07/2008
Paul M, Lahlou A, Carvalho M, Blanchet B, Astier A.
Thermal stability of two monoclonal antibodies : cetuximab and bevacizumab.
EJOP 2008 ; 2, 1 : 37.



15/07/2008
Formulation and thermal sterile stability of a less painful intravenous clarithromycin emulsion containing vitamin E
Pages 47-56
Yan Lu, YanJiao Wang and Xing Tang
Int J Pharm 2008; 546+, 1-2: 47-56.



11/07/2008
Anti-Xa Stability of Diluted Dalteparin for Pediatric Use
Neil A Goldenberg, Linda Jacobson, Hannah Hathaway, Mark Tripputi, Judy Primeaux, Jason Child
Ann of Pharmacother2008, 42, 4: 511-515



08/07/2008
Stability of cefuroxime in BSS solution.
This new poster was presented at the XII Congress of the French Sociiety of Clinical Pharmacists in February 2008 (Saint malo - France)
The poster can be downloaded. See in "Publication" and "Stability and compatibility"
With the authorization of the authors.


04/07/2008
Identification and quantification of degradations in the Asp–Asp motifs of a recombinant monoclonal antibody
Gang Xiao , and Pavel V. Bondarenko
Journal of Pharmaceutical and Biomedical Analysis
Volume 47, Issue 1, 12 May 2008, Pages 23-30





01/07/2008
Improving the stability of potassium clavulanate in admixture with amoxicillin
By Elena M. Vega, BSc, PhD, Ruben H. Manzo, BSc, PhD and Nancy Sola, BSc, PhD
Hospital Pharmacist   2008;15:183-185



27/06/2008
Silicate release from glass for pharmaceutical preparations
Denise Bohre , Fabiana Bortoluzzi, Paulo Cícero Nascimento, Leandro Machado Carvalhoa and Adrian Gustavo Ramirez
International Journal of Pharmaceutics 2008, 355, 1-2 : 174-183.





24/06/2008
Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders
Jichao Kang, Oliver Lambert , Michael Ausborn and Steven P. Schwendeman
International Journal of Pharmaceutics 2008, 357, 1-2: 235-243.



20/06/2008
Stability of metoprolol tartrate injection 1 mg/mL undiluted and 0.5 mg/mL in 0.9% sodium chloride injection and 5% dextrose injection
Michael D. Kraft, Cary E. Johnson, Christopher Chung and Frank Julian
American Journal of Health-System Pharmacy, Vol. 65, Issue 7, 636-638 2008



17/06/2008
Stability of Levalbuterol in a Mixture of Levalbuterol and Ipratropium Nebulizer Solution
Weeranuj Yamreudeewong, M. Glaucia Teixeira, and Gabriele E. Mayer
Hosp Pharm 2008; 43: 303-306.



13/06/2008
Physicochemical Stability of Parenteral Nutrition Supplied as All-in-One for Neonates
Maria Skouroliakou, Chrysoula Matthaiou, Antonia Chiou, Demosthenes Panagiotakos, Antonis Gounaris, Tony Nunn and Nikolaos Andrikopoulos.
Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 2, 2008 201-209




10/06/2008
Two news poster on the stability of cytotoxic drugs can be downloaded . See in "Publications" and "Stability and compatibility"


06/06/2008
Trusley C, Ben M, Kupiec TC, Trissel LA.
Compatibility and stability of palonosetron hydrochloride with four neuromuscular blocking agents during simulated Y-site administration.
Int J Pharm Compound 2008; 12, 2: 156-160.



03/06/2008
Kupiec T, Ben M, Trusley C, Trissel LA.
Compartibility and stability of palonosetron hydrochloride with gentamicin, metronidazole, or vancomycin during simulated Y-sirte administration.
Int J Pharm Compound 2008; 12,2: 170-173.



30/05/2008
Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization
Jiaher Tian , Valentino J. Stella.
J Pharm Sci 2008; 97, 3: 1224-1235.



27/05/2008
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection
Raf De Jongh1, Ria Hens1, Violetta Basma2, Johan W. Mouton3, Paul M. Tulkens2,* and Stéphane Carryn2
J Antimicrob Chemother 2008 ; 61, 2 : 382-388.



23/05/2008
Gupta V.D.
Chemical stability of tramadol hydrochloride injection.
Int J Pharm Compound 2008; 12, 2: 161-162.



20/05/2008
Stability of TPN: influence of electrolytes
You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Stabilité des TPN: influence des électrolytes »
http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm



16/05/2008
Stability of Bortezomib Reconstituted with 0.9% Sodium Chloride at 4°C and Room Temperature (23°C)
Scott E Walker, Debbie Milliken, and Shirley Law
Can J hosp Pharm 2008; 61, 1



13/05/2008
Chemical stability of haloperidol injection by high performance thin-layer chromatography
Sigrid Mennickent, Loreto Pino , Mario Vega , Marta de Diego
J  Sep Sci 2008 ; 31, 1 : 201-206.


09/05/2008
Risks associated to injectable drugs
You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Risques liés aux médicaments injectables »
http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm



06/05/2008
Total parenteral nutrition – problems in compatibility and stability
Allan Mikael Schroder
EJHP Practice 2008; 14, 1: 65-67.




02/05/2008
Visual compatibility of caspofungin acetate with commonly used drugs during simulated Y-site delivery
Chad K. Condie, Linda S. Tyler, Brian Barker and David M. Canann
American Journal of Health-System Pharmacy, Vol. 65, Issue 5, 454-457



29/04/2008
Extended stability of iobenguane under simulated clinical conditions
George H. Hinkle, Jillian V. Dura, Richard S. Morosco and Milap C. Nahata
American Journal of Health-System Pharmacy, Vol. 65, Issue 2, 142-144



25/04/2008
Study of protein conformational stability and integrity using calorimetry and FT-Raman spectroscopy correlated with enzymatic activity
A.A. Elkordy , a,  , R.T. Forbesa and B.W. Barrya
Eur J Pharm Sci 2008; 33, 2: 177-190.





22/04/2008
Calcium and phosphate compatibility: Revisited again
David W. Newton and David F. Driscoll
Am J Health Syst Pharm 2008 65: 73-80.



18/04/2008
Strategy for identification of leachables in packaged pharmaceutical liquid formulations
Changkang Pan, Ferris Harmo, Karen Toscano, Frances Liu and Richard Vivilecchia
J Pharm Biomed Anal 2008; 46, 3: 520-527.



15/04/2008
A new poster can be freely downloaded. See "Publications" and "Stability and compatibility"
Comparative of different intravenous infusion containers.
This poster was presented at the 10th Congress of the European Association of Hospital Pharmacists. Lison, Portugal, 16-18 March 2005.



11/04/2008
Hong Yao Zhanga, Xing Tang , a,  , Hong Ying Lia and Xiao Liang Liua
A lipid microsphere vehicle for vinorelbine: Stability, safety and pharmacokinetics
International Journal of Pharmaceutics 2008;348 ,1-2: 70-79



08/04/2008
Adwoa O. Nornooa, Diana S.-L. Chowb
Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
International Journal of Pharmaceutics 208; 349, Issues 1-2, 117-123





04/04/2008
Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis
Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids
Journal of Separation Science 2006 ; 29, 11 : 1550-1560.



01/04/2008
Tiffany Derrick, Adeola O. Grillo, Samadhi N. Vitharana, LaToya Jones, Jason Rexroad, Ambarish Shah, Melissa Perkins, Thomas M. Spitznagel, C. Russell Middaugh.
Effect of polyanions on the structure and stability of repiferminTM (keratinocyte growth factor-2)
J Pharm Sci 2007; 96, 4: 761-776.


28/03/2008
Frederic Adnet, Laurence Le Moyec, Charles E Smith, Michel Galinski, Patricia Jabre1, Frederic Lapostolle
Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy
Emergency Medicine Journal 2007;24:168-169



25/03/2008
Kupiec Thomas C, Skinner Rodney, Lanier Lance
Quality-Control Analytical Methods: Stability Versus Potency Testing: The Madness is in the Method
Int J Pharm Compound 2008 ; 12, 1 : 50-53



21/03/2008
Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin - EDM Research Series N° 08
On WHO website


18/03/2008
Roberto Sacco, Giovanna Sacchetto, Mirella Francalanci, Cinzia Boselli
Studio di stabilità chimico-fisica di una formulazione per la terapia antalgica a base di levobupivacaina e fentanyl
Bolletino SIFO 2-2006



11/03/2008

Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T, Forest Jean-Marc, Hildgen Patrice
Room Temperature Stability of Injectable Succinylcholine Dichloride
Int J Pharm Compound 2008 ; 12, 1 : 83-85.



07/03/2008
Cristiana Romanazzi, Stella Sferra, Anna Campi, Barbara Rabino, Marco Barbieri, Sofia Castellani, Luana Sabbatini, Paola Scanavacca
Dexrazoxane: stabilità in soluzione
Bolletino SIFO 2007;53 ,4 : 178-180




04/03/2008
Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids
Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis
Journal of Separation Science 2006 ; 29, 11 : 1550-1560.



29/02/2008
Stabilis online !
Click on "Stabilis" on the left side on the screen and then click on the button "Stabilis"
By choosing "List of drugs", you have access to 374 monographs of injectable drugs with informations on stability in solutions, in admixtures, incompatibilities ...

29/02/2008
Stability of a mixture of technetium Tc 99m sulfur colloid and lidocaine hydrochloride
Jillian V. Dura and George H. Hinkle
Am J Health Syst Pharm 2007; 64, 23: 2477-2479.



26/02/2008
A Comparison of Plasticizers for Use in Flexible Vinyl Medical Products
Data from three studies suggest that using trimellitates can reduce the amount of plasticizer that may migrate from PVC devices.
Richard C. Adams
Medical Device Link dec 2007



22/02/2008
Diethylhexylphthalate Extracted by Typical Newborn Lipid Emulsions From Polyvinylchloride Infusion Systems Causes Significant Changes in Histology of Rabbit Liver
P. D. Steffan Loff, Ulrike Subotic, Jasmina Oulmi-Kagermann, Bettina Kränzlin, Maria-Franziska Reinecke and Christiane Staude
Journal of Parenteral and Enteral Nutrition, Vol. 31, No. 3, 2007 188-193



19/02/2008
New links to articles or posters have been placed into the list "Stability and compatibility". See "Publications" and "Stability and compatibility".


12/02/2008
Chemical stability of midazolam injection by high performance liquid chromatography
Marta de Diego, Gloria Godoy,Sigrid Mennickent
Journal of Separation Science 2007 ; 30, 12 : 1833-1838.



11/02/2008
STABILIS online !
The database STABILIS is now available on the website. You have to choose "Stabilis" on the menu at the left side of the screen.
The database contains important improvements like a general search function, a search function for incompatibilities, possibility to create a pdf file for each monograph etc.
Don't hesitate  to give your opinion about the new Stabilis database by using the email adress : infostab@wanadoo.fr


29/01/2008
An alternative to DEHP plasticized polyvinyl chloride in chemotherapy drug delivery systems
Len Czuba, Harry Puryear, Kamal Sarkar.
Journal of Vinyl and Additive Technology 2004 ; 2, 4 : 314-320.



25/01/2008
Dual effects on Tween 80 on protein stability
Wang W, Wang Y.J, D.Q. Wang D.Q.
Int J Pharm 2008 ; 347, 1-2 : 31-38.



22/01/2008
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Int J Pharm Compound 2007; 11, 6: 520-524.



18/01/2008
Tracking of the Kinetic Stability of 2 Types of Total Nutrient Admixtures Containing Different Lipid Emulsions
Judit Balogh, Dorottya Kiss, Judit Dredán, István Puskás, Ferenc Csempesz, and Romána Zelkó
AAPS PharmSci. 2006; 7(4)



15/01/2008
A rapid technique to evaluate the oxidative stability of a model drug.
Felton LA, Yang J, Shah K, Omidian H, Rocca JG
Drug Dev Ind Pharm 2007 Jun; 33(6):683-9.



15/01/2008
Stability of 70% alcohol solutions in polypropylene syringes for use in ethanol-lock therapy
Mary Petrea Cober and Cary E. Johnson
Am J Health Syst Pharm 2007; 64, 23: 2480-2482.



11/01/2008
Evaluation of the chemical compatibility of plastic contact materials and pharmaceutical products; safety considerations related to extractables and leachables
Dennis Jenke *
J Pharm Sci 2007; 96, 10: 2566-2581.



08/01/2008
Stability of vecuronium in sterile water for injection stored in polypropylene syringes for 21 days
Cary E. Johnson and Mary Petrea Cober
Am J Health Syst Pharm 2007; 64, 22: 2356-2358.




04/01/2008
de Diego M, Godoy G, Mennickent S
Chemical stability of midazolam injection by high performance liquid chromatography.
J Sep Sci 2007 Jun 12.



01/01/2008
Compatibility and stability of tramadol and dexamethasone in solution and its use in terminally ill patients
S. Negro, A. Salam, Y. Sánchez, M. L. Azuara, E. Barcia.
J Clin Pharm Ther 2007; 32, 5: 441-444.




28/12/2007
Amélioration des pratiques d’administration des antibiotiques injectables : proposition et évaluation d’un guide de compatibilité physico-chimique (in french)
A Camut, V Noirez, B Gustin, A Khalife
J Pharm Clin 2007; 26, 3: 143-150.





25/12/2007
Accelerated aging: Prediction of chemical stability of pharmaceuticals
Kenneth C. Waterman ,  and Roger C. Adami
Int J Pharm 2005; 293, 1-2: 101-125.



21/12/2007
A Four-Column Approach to Developing Stability-Indicating HPLC Methods
This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients.
LCGC North America, Jun 1, 2002



18/12/2007
Liposomal amphotericin B eye drops to treat fungal keratitis: Physico-chemical and formulation stability
K. Morand, A.C. Bartoletti, A. Bochot, G. Barratt, M.L. Brandely and F. Chast
Int J Pharm 2007; 334, 1-2: 150-153.



14/12/2007
Influence du stress  mécamique sur la stabilité du bévacizumab. (in french)
Lahlou, Blanchet B, Carvalho M, Astier A, Paul M.
Presented at the SFPO Congress in Nice (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.



11/12/2007
Liposome formulation of Paclitaxel with enhanced solubility and stability.
Yang T, Cui FD, Choi MK, Lin H, Chung SJ, Shim CK, Kim DD
Drug Deliv 2007 Jun; 14(5):301-8.


07/12/2007
Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion.
Tian L, He H, Tang X
J Pharm Sci 2007 May 14.



04/12/2007
Stabilité thermique de 2 anticorps monoclonaux : bevacizumab et cetuximab. (in french)
Paul M, Lahlou A, Carvahlo M, Blanchet B, Astier A.
Presented at the SFPO Congress in Nice (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.


30/11/2007
Stability of Docetaxel Solution after Dilution in Ethanol and Storage in Vials and after Dilution in Normal Saline and Storage in Bags.
Scott E Walker, Flay Charbonneau, and Shirley Law
Can J Hosp Pharm 2007; 60, 5: 217-284.


27/11/2007
Are monoclonal antibody stable ? (in french)
Pr Alain ASTIER
Presented at the  SFPO Congress in Nice  (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.


23/11/2007
A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate 'dose-banding'.
Kaestner S, Sewell G.
In this study, the authors have demonstrated that carboplatine infusions could be stored refrigerated for 84 days.
J Oncol Pharm Practice 2007; 13: 119-126.


20/11/2007
Examination of stability and compatibility of flucloxacillin (Floxapen®) and ceftazidime (Fortum®) in two infusion media: relevance for the clinical praxis.
Florian Thalhammer, Alexandra Maier-Salamon und Walter Jäger.
Wien Med Wochenschr 2005 ; 155 (13-14) : 337-343.


16/11/2007
Compatibility of insulin over 24 hours in standard and bicarbonate-based peritoneal dialysis solutions contained in bags made of different materials.
Voges M, Divino-Filho JC, Faict D, Somers F, Vermeulen P.
Perit Dial Int 2006 Jul-Aug; 26(4) :498-502.


13/11/2007
Pathological Consequences From the Infusion of Unstable Lipid Emulsion Admixtures in Guinea Pigs.
Todd Canada.
Nutrition in Clinical Practice 2006; 21, 6: 636-637.


09/11/2007
Stability and compatibility of histamine H2-receptor antagonists in parenteral nutrition mixtures.
Puzovic M, Hardy G.
Curr Opin Clin Nutr Metab Care 2007 May; 10(3) :311-7.


09/11/2007
Physicochemical stability of lipid injectable emulsions: Correlating changes in large globule distributions with phase separation behavior.
Thomas Gonyon, Pankaj Patel, Heather Owen, Andrew J. Dunham and Phillip W. Carter.
Int J Pharm 2007; 343, 1-2: 208-219.


06/11/2007
Estabilidad de parecoxib en dilución con otros fármacos y administrado en perfusión continua IV para el control del dolor postoperatorio.
Acín Lázaro MP, Bono Ariño C, Martínez Bazán R, Manzanares Marín I, Faci Bouthelier A,
Velamazán Blocona MJ, Facorro Gaspar E, Sanz Gandasegui M, Aleploglian Barbarian K
Investig. Clin. Farm. 2005, Vol. 2 (4): 195-203


02/11/2007
Stability of oxaliplatin in infusion bags containing 5% dextrose injection.
Pascal André, Salvatore Cisternino, Anne-Lise Roy, Fouad Chiadmi, Joël Schlatter, Pascal Agranat, Olivier Fain and Jean-Eudes Fontan
Conclusion. Oxaliplatin 0.7 mg/mL in infusion bags containing 5% dextrose injection was chemically stable for at least 30 days at both 3–7 °C and 20–24 °C without regard to light exposure.
Am J Health-Syst Pharm,2007;64,18/1950-1954


30/10/2007
Use of microcalorimetry and its correlation with size exclusion chromatography for rapid screening of the physical stability of large pharmaceutical proteins in solution.
Burton L, Gandhi R, Duke G, Paborji M
Pharm Dev Technol 2007; 12(3) :265-73.


26/10/2007
Validation of an HPLC method for the analysis of decomposition products in injectable diazepam.
Hudecová T, Bátorová V, Hatrík S, Havránek E
Ceska Slov Farm 2004 Sep; 53(5) :228-33.


23/10/2007
Compatibility and stability of furosemide and dexamethasone combined in infusion solutions.
Negro S, Rendon AL, Azuara ML, Sánchez Y, Fernández-Carballido A, Barcia E
These results confirm the stability of mixtures prepared with sodium furosemide (< or = 120 mg/day) and dexamethasone sodium phosphate (< or = 40 mg/day) for a period of 5 days and with independence of their storage at 4 degrees C or 25 degrees C.
Arzneimittelforschung 2006; 56(10) :714-20.


19/10/2007
Long-term stability of sodium folinate  in dextrose 5% polyolefin bags at 4°C.
Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
J Oncol Pharm Practice 2007; 13: 99-103.


16/10/2007
Shelf-lives of IV products — are there any limits?
By Michael Allwood, PhD, FRPharmS and Graham Sewell, PhD, MRPharmS
Hospital Pharmacist   2007;14:242



12/10/2007
Ortega Valín L, del Pozo Ruiz JJ.
Cómo y por qué estudiar la estabilidad de las mezclas de fármacos para uso intravenoso
Investig. Clin. Farm. 2006, Vol. 3 (3): 130-135



09/10/2007
Mário L de Lemos, Linda Hamata
Stability issues of parenteral chemotherapy drugs
Journal of Oncology Pharmacy Practice, Vol. 13, No. 1, 27-31 (2007)


05/10/2007
A simulation study with statistical evaluation for the determination of non-isothermal kinetics conditions in drugs stability
Eur J  Pharm Sci; 2007; 31, 5: 277-287.



02/10/2007
Stability of an extemporaneously prepared recombinant human interferon alfa-2b eye drop formulation.
Conclusion. An extemporaneously pre -pared rh-IFN- 2b eye drop formulation was stable at 5 ± 3 °C for 15 days and at 28 ± 2 °C for 7 days.
Am J Health Syst Pharm;  64, 16: 1716-1719.


28/09/2007
Incompatibility reactions in iv drug therapy : Preventable medication errors.
Presented by Pr Stefan Muhlebach, Bern, Switzerland during the EAHP congress in Bordeaux, France, march 2007.
You can download the pdf file. See in "Publications" and "Stability and compatibility"
With the authorization of the author.


25/09/2007
Incompatibility of iv drugs in daily practice : an underrecognised and underestimated problem.
by Karin Nemec, PhD from Vienna, Austria
Presented during the seminar "Incompatibility reactions in drug therapy – preventable medication errors" in the EAHP Congress in Bordeaux, France,  march 2007.
You can download the pdf file. See in "Publications" and "Stability and compatibility"
With the authorization of the author


21/09/2007
Room-temperature storage of medications labeled for refrigeration.
Conclusion. Information regarding the room-temperature storage of 79 medications labeled for refrigerated storage was compiled.
Am J Health Syst Pharm 2007; 64, 16: 1711-1715.



18/09/2007
Viability of micro-organisms in novel anticancer drug solutions.
Conclusion : Micro-organisms can survive in diluted solutions of antineoplastic drugs and proliferate when transferred to proper growth media.
EJHP-Science 2007; 13, 2: 27-32.


14/09/2007
Development and validation of a simple HPLC method for simultaneous in vitro determination of amoxicillin and metronidazole at single wavelength.
J Pharm Biomed Anal 2007; 43, 1: 325-329.



11/09/2007
Stability issues of parenteral chemotherapy drugs.
J oncol Pharm Practice 2007; 13: 27-31.


07/09/2007
Stability of a heparin-free 50% ethanol lock solution for central venous catheters.
These findings suggest that a 50% (v/v) ethanol solution stored in a syringe at room temperature, not protected from light is stable over a 28 day period
J Oncol Pharm Practice 2007; 13: 33-37.


03/09/2007
Hitchingham L, Thomas VH.
Development of a semi-automated chemical stability system to analyse solution based formulations in support of discovery candidate selection.
This paper describes the semi-automated chemical stability system (SACSS) set-up, method validation and use. This process has proven to be a good indicator of chemical and physical stability in greater than 90% of the compounds tested.
Ref : J Pharm Biomed Anal 2007; 43: 522-526.



03/09/2007
Development and validation of a stability-indicating analytical method
for the quantitation of oxytocin in pharmaceutical dosage forms
J Pharm Biomed Anal 2007;43,1: 179-185.



31/08/2007
Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion
The shelf life (T90%) of etoposide in lipid emulsion was estimated to be 47 days at 25°C and it would be stable when stored for 427 days at 4°C, which is a significant improvement compared with a stability of 9.5 days in aqueous solution at 25°C.
J Pharm Sci 2007; 96, 7: 1719-1726.



28/08/2007
Stability of palonosetron in Y-site
Physical and chemical stability of palonosetron with metoclopramide and promethazine during simulated Y-site administration.
Results : Palonosetron hydrochloride is physically compatible and chemically stable with undiluted metoclopramide hydrochloride and also with promethazine hydrochloride diluted in 5% dextrose injection during simulated Y-site administration.
Ref: Int J Pharm Compound 2007 ; 11, 1 : 82-85



24/08/2007
Physical compatibility and chemical stability of mycophenolate mofetil during simulated Y-site administration with commonly coadministered drugs
Conclusion. Mycophenolate mofetil was physically compatible and chemically stable with vancomycin, cefepime, norepinephrine, dopamine, and tacrolimus for up to four hours of simulated Y-site administration. The physical compatibility of mycophenolate mofetil with cyclosporine could not be confirmed.
Am J Health Syst Pharm 2007; 64, 13, 1410-1414.


21/08/2007
Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability.
In this study, the authors have demonstrated that Tramadol HCl (100-400 mg/day) can be formulated together in saline with hyoscin N-butyl bromide (dose range 40-80 mg/day) for sc infusion using a 60 ml drug infuser for a duration of 7 days.
Ref : Support Care Cancer 2007; 15: 57-62.



17/08/2007
Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique
Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated.
Pharmazie 2007; 62, 5: 327-336.



14/08/2007
Xiao B, Gozo SK, Herz L.
Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products.
J Pharm Biomed Anal 2007; 43: 558-565.
In this paper, HPLC methods were developped and validated for potential extractables from commercial elastomeric stoppers in a complex surfactant matrix.



07/08/2007
Peut-on conditionner les solutions de docétaxel dans des poches en PVC ?
In this paper, the authors have demonstrated that docetaxel solutions were stable for 48 hours in PVC and poyethylene containers. However, PVC infusion bags should be avoided  because the leaching of plasticizer after the injection of docetaxel. The DEHP concentration increases with time.
J Pharm Clin 2006; 25, 3: 147-152.



03/08/2007
Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique
Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated.
Pharmazie 2007; 62, 5: 327-336.


31/07/2007
Physical stability of 20% lipid injectable emulsions via simulated syringe infusion: Effects of glass vs plastic product packaging.
J Parent and Enter Nutr 2007; 31, 2: 148-153.


27/07/2007
Stability of busulfan in polypropylene syringes
Busulfan injection (Busilvex®, Busulfex) stored in B/Braun syringes at 18-20°C without light protection or refrigerated was stable for up to 28 days. Unused busulfan injection is not necessarily to be discarded but can be stored for a prolonged period of time in a rubber free syringe, preferably under refrigeration.
Ref: Pharmazie 2006; 61: 845-850.



24/07/2007
Stability of ertapenem in aqueous solutions.
In this study the kinetics of ertapenem was studied in aqueous solutions at various pH by using two HPLC methods. Ertapenem has the greatest stability at pH 5-6.
Ref : J Pharm Biomed Anal 2007; 43: 445-449.


20/07/2007
Stability of oxytocin
Oxytocin was demonstrated to be physically and chemically stable when admixed in 5% dextrose injection or 0.9% sodium chloride inujection for 90 days and stored at room temperature (near 23°C). However, oxytocin in lactated Ringer’s injection should be restricted to a use period no longer than 28 days at room temperature to prevent microprecipitate formation and drug loss.
Ref: Int J Pharm Compound 2006; 10, 2: 156-158.



17/07/2007
A physical and chemical stability of amphotericin B lipid complexes (Abelcet)after dilution in dextrose 5%.
EJHP-Science 2007; 13, 1: 10-13.


13/07/2007
Isolation and characterisation of degradation impurities in docetaxel drug substances and its formulation.
J pharm Biomed Anal 2007; 43: 1228-1235.



10/07/2007
Stability of pemetrexed 25 mg/ml in a glass vial and 5 mg/ml stored in a PVC container after storage for one month at 2-8°C.
EJHP-Science 2007; 13, 1: 14-16.


06/07/2007
Recent developments on long-term stability test conditions.
Singh S, Kumar V.
This article can be downloaded on the website of the American Association of Pharmaceutical Scientis
http://www.aapspharmaceutica.com/inside/focus_groups/Stability/index.asp#top



03/07/2007
Incompatibility of phenytoin
Incompatibility: Phenytoin is incompatible with vasopressin by immediate formation of a precipitate.
Ref: Am J Health Syst Pharm 2005; 62: 1969-1976.


29/06/2007
Drug compatibility with new polyolefin infusion solution containers
Of the seven drugs subject to sorption to PVC, only insulin showed a substantial loss in the VISIV containers. Carmustine exhibited a loss consistent with the drug’s known chemical stability. None of the drugs that are known to leach plastic components, such as DEHP plasticizer, from PVC equipment exhibited any leached components in the VISIV containers.
Ref: Am J Health Syst Pharm 2006; 63: 2379-2382.



26/06/2007
«Stability studies – Assessment experience » was presented at the WHO training workshop on pharmaceutical quality, GMP and bioequivalence with a focus on artemisenines. Guilin, China, 9 January 2006 by Pr JANOS POGANY.
http://mednet3.who.int/prequal/trainingresources/pq_pres/workshop_China_Jan2006/StabilityStudies.ppt



22/06/2007
Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%® and Dianeal PD1 3·86%®)
The mean moxifloxacin concentration in the Dianeal PD1 1·36% solution remained ≥90% of the initial concentration for 14 days at 4 °C, 7 days at 25 °C and 3 days at 37 °C. For Dianeal PD1 3·86%® moxifloxacin concentrations remained ≥90% for 14 days at 4 °C, 3 days at 25 °C and 12 h at 37 °C.
Ref: J Clin Pharm Ther 2006; 31: 641-643.



19/06/2007
Stability studies of drugs used in oncology : the role of the hospital pharmacist
Published in EJHP practice 2006, 6 : 75-76.



15/06/2007
Stability of vancomycine
Vancomycine hydrochloride in 5% dextrose polyolefin bags may be frozen and thawed in a microwave oven without major changes that affect concentration. Subsequent storage of the bags at 4°C is possible for at least 56 days. Within those limits, vancomycin can be prepared in advance by a centralized service, frozen, thawed and stored under refrigeration for a few days before use in hospital wards
Ref: EJHP-S 2005; 11, 5: 111-113.



12/06/2007
Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration
Conclusion. Palonosetron hydrochloride was physically and chemically stable with fentanyl citrate, hydromorphone hydrochloride, meperidine hydrochloride, morphine sulfate, and sufentanil citrate during simulated Y-site administration.
Am J Health Syst Pharm 2007; 64,11: 1209-1213.



08/06/2007
Stability of mitomycine C for intraperitoneal administration
Poster présented at Synprefh Congress in France may 2006
Can be downloaded : see in "Publications" >> "Stability and compatibility"


05/06/2007
Stability of phenylephrine hydrochloride injection in polypropylene syringes
Conclusion. Phenylephrine hydrochloride diluted to a concentration of 100 µg/mL in 0.9% sodium chloride injection was stable for at least 30 days when stored in polypropylene syringes at –20 °C, 3–5 °C, and 23–25 °C.
Am J Health Syst Pharm 2007; 64, 10: 1092-1095.


01/06/2007
Stabilis 3 a european database on the stability and compatibiity of injectable drugs.
In EJHP 2006, 6: 77-78.





29/05/2007
Ketamine incompatibility
Physical incompatibilities were observed between ketamine and acyclovir, ampicilline, sodium bicarbonate, furosemide, heparin, insulin, meropenem, phenytoin, potassium phosphate, trimethoprim/sulfametoxazole.
Ref: Pharmactuel 2006; 39, 2: 71-75.



25/05/2007
Stability of dolasetron
Dolasetron mesylate solutions (Anzemet®)) 20 mg/ml in syringes are stable for up to eight months at room temperature
Ref: Am J Health Syst Pharm 2005; 62: 896-899.


22/05/2007
Long-term physical and chemical stability of a generic paclitaxel infusion
The stability of paclitaxel was limited by physical stability and this was dependent on paclitaxel concentration in the infusion, diluent used and the storage temperature.
Ref: EJHP-S 2006; 12, 6: 129-134.



19/05/2007
Send your posters to the INFOSTAB website !
You have recently  presented a poster on stability or compatibility of injectable drugs during a congress.  You can now present your research to the hospital pharmaceutical community by publishing your poster in the Infostab website (in "Publications" and "Stability and compatibility"). Send your poster in pdf format to the following address: infostab@wanadoo.fr


18/05/2007
Stability of ondansetron + methylprednisolone + clorazepate dipotassium diluted in dextrose 5% : you can download the poster which has be presented at the Hopipharm Congress in France in mai 2006. (poster in french).

See in the menu : "Publications" and "Stabilité and compatibilité"

15/05/2007
Stability of vancomycin in syringes
The vancomycin (5 mg/ml) was found to be chemically and microbiologically stable at 4°C for 6 months. Losses were important after 14 days at 25°C.The samples subjected to simulated ward conditions were stable for 48 hours at 25°C.
Ref EJHP-S 2006; 12, 6: 135-139.



12/05/2007
Dose banding - Cytotoxic drug standardization : establish the positive list of anticancer drugs to be standardized taking into account pharmacokinetic and stability studies.
Workshop at the Gerpac Congress in Belgium (Sunparks Kempense Meren - Mol) October 3-5 2007.
First announcement and registration form can be downloaded on the Gerpac webste : http://www.gerpac.org


11/05/2007
Stability of voriconazole
Voriconazole injection 2mg/ml, when protected from light, was stable for eight days when stored at 4 or 25°C in 0.9% sodium chloride injection, six days at 4°C in 5% dextrose injection, and four days at 25°C in 5% dextrose injection.
Ref: Am J Health Syst pharm 2006; 63: 1426-1426.


08/05/2007
A new interesting link has been created towards the " Association of Pharmaceutical Scientists – Stability focus group"
See in "Links" and "Others links"



04/05/2007
World Health Organization (WHO)
Stability testing of active substances and pharmaceutical products.
This draft guideline can be downloaded on the website of the American Association of Pharmaceutical Scientists (Stability focus group).
http://www.aapspharmaceutica.com/inside/focus_groups/Stability/index.asp#top



01/05/2007
The poster "Assessment of injectable drug administration in two intensive care units and determination of potential physico-chemical incompatibilities" presented during the EAHP Congress in Geneva (march 2006) can be freely downloaded.
See in "Publications" and "Stability and compatibility".

27/04/2007
A new link has been added to present : "Stability-Indicating HPLC Methods for Drug Analysis" from L.A TRISSEL.
See in "Link" and "Guidelines"


24/04/2007
"Asean Guideline on stability study of drug products" has been added in the "Guidelines list".
See in "Links" and "Guidelines"


20/04/2007
Stability of vancomycin in icodextrin peritoneal dialysis solution.
Premixed vancomycin-icodextrin PD solution, whether stored refrigerated or at room temperature, were found to be stable for up to 7 days. Solutions stored at body temperature were stable for up to 24 hours, permitting the practice of prewarming solutions prior to administration.
Ref: Ann Pharmacother 2006; 40, 11: 1950-1954.



17/04/2007
Effect of tubing on loss of clonazépam administered by continuous subcutaneous infusion.
Significant loss of clonazépam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used.
Ref: J Pain Sympt Manage 2006; 31, 6: 563-567.



13/04/2007
Stability of ketamine and remifentanil : you can download the poster that has be presented at the EAHP Congress in Geneva in 2006.
See in the menu : "Publications" and "Stability and compatibility"

10/04/2007
Stability and compatibility of a meperidine-clonidine mixture.
A mixture of meperidine hydrochloride and clonidine remains stable in a PVC-containing reservoir, at room temperature and unprotected from daylight for at least 21 days.
Ref: J Pain Symptom Manag 2006; 32, 4: 297-299.



06/04/2007

Study of the compatibility of cefotaxime with tinidazole in glucose injection.
In this study, the admixture cefotaxime and tinidazole was stable for 8 hours in dextrose 5%.

J Pharm Biomed Anal 2007; 43: 1849-1853.

05/04/2007
The Infostab website is now translated into  21 languages (italian has been added, translation performed by Camillo Cettuzzi)

03/04/2007
Incompatibility irinotécan/epirubicin
A chemical interaction was observed using a spectrophotometric method in the spectra of irinotecan and epirubicin. The chemical interaction occured immediately after admixing  and no visual or spectral changes was noticed for 24 hours after the intercation had occured. No sign of physical incompatibility was observed upon visual examination by means of effervescence, pH change, precipitation and colour change.
Ref: Cancer Chemother Pharmacol 2005; 56: 529-534.



30/03/2007
Stability of paracetamol-phloroglucinol admixture.
Paracetamol and phloroglucinol, prepared by adding phloroglucinol to a glass bottle of paracetamol ready to-use solution, were stable and compatible for up to 48 hours at room temperature without any protection against light.
Ref: EJHP-S 2006; 12, 5: 91-95.



30/03/2007
Stability of total nutrient admixtures with lipid injectable emulsions in glass versus plastic packaging.
In this paper, the physical stability of two emulsions compounded as part of a total nutrient admixture (TNA) was studied in lipids packaged in either glass or plastic containers.
Am j Health Syst Pharm 2007; 64, 4: 396-403.
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28/03/2007
The Infostab website is now translated into  20 languages (turkish has been added, translation performed by Aygin Bayraktar)

27/03/2007
Stability of palonosetron
Palonosetron HCl (Aloxi®) is physically and chemically stable with doxorubicin HCl and epirubicin HCl during simulated Y-site administration of these drugs over 4 hours at ambient room temperature.
Ref: Ann Pharmacother 2005; 39: 280-283.


23/03/2007
Stability of tazocilline
Tazocin® (piperacillin/tazobactam) was found to be stable in 0.9% sodium chloride in PVC bags for up to 5 days at 7°C and 4 days at room temperature in the light. In non-PVC bags, it was stable for 17 and 3 days respectively.
Ref: J Pharm Biomed Anal 2005; 39: 339-343.


20/03/2007
Stability of tramadol and haloperidol
The mixture tramadol and haloperidol lactate diluted in NaCl 0.9% in polypropylene syringes is stable for 15 days at room temperature  protected from light and in the refrigarator.
Ref: J Pain Symptom Manag 2005; 30: 193-199.


16/03/2007
The stability of anticancer drugs by Alain ASTIER
EJHP-P 2007, 2: 90-92.


13/03/2007
Stability of dexrazoxane : you can download the poster that will be presented at the EAHP Congress in Bordeaux (France) 21,22,23 march.
See in the menu : "Publications" and "Stabilité and compatibilité"


09/03/2007
Stability of palonosetron admixtures
Palonosetron hydrochloride was physically and chemically compatible with cyclophosphamide and with ifosfamide during simulated Y-site administration.
Ref: Am J Health Syst Pharm 2005; 62: 1998-2000.



02/03/2007
Stability of ondansétron and methylprednisolone
Ondansetron 0.16  mg/ml and methylprednisolone 2.4 mg/ml mixed in 50 ml multilayer polyolefin bags (Macoflex N®) were stable in both 5% dextrose injection and 0.9% sodium  chloride injection for up to 24 hours at 20-25°C and up to 48 hours at 4-8°C.
Ref: Am J Health Syst Pharm 2005; 62, 1: 2001-2005.



02/03/2007
The Infostab website is now translated into  19 languages (slovenian and croatian have been added, translation performed by Silva Pecar Cad and Karin Kasesnik (SLO) and Danijela jonjic (HR))

27/02/2007
Stability of ketorolac tromethamine
Ketorolac tromethamine in dextrose 5% 100 ml polyolefin infusion bags may be frozen for 3 months and microwave thawed, without major changes that affect concentration. Ketorolac tromethamine solution may subsequently be stored at 4°C for up to 60 days.
Ann Pharmacother 2005; 39: 1654-1658.



23/02/2007
The Infostab website is now translated into  17 languages (russian has beenadded, translation performed by Violeta Kontrimaviciute)



20/02/2007
Stability of dexamethasone and ketamine
The mixtures of dexamethasone sodium phosphate (1 mg/14 ml) with ketamine hydrochloride (50 mg/14ml) in 0.9% sodium chloride were physically and chemically stable when stored in plastic syringes at 4°C, 23°C and 37°C and exposed to normal fluorescent light for 8 days.
Ref: J Pain Symptom Manage 2005; 30: 80-86.



16/02/2007
The Infostab website is now translated into  16 languages (lithuanian has been added, translation performed by Violeta Kontrimaviciute)



13/02/2007
Palonosetron stability
Palonosetron hydrochloride 25µg/ml (Aloxi®) is physically and chemically stable with lorazepam 0.25 mg/ml and midazolam HCl 1 mg/ml  in dextrose 5% during simulated Y-site injection.
Ref: Int J Pharm Compound 2005; 9, 3: 235-237.



09/02/2007
The Infostab website is now translated into  15 languages (hungarian has been , translation performed by Lívia Sáfrán)



06/02/2007
Stabilnost vorikonazola
The solution of voriconazole 4 mg/ml diluted in dextrose 5% in PVC bags is stable for at least 15 days at 4°C.
Ref: EJHP-S 2006; 12, 3: 57-59.



02/02/2007
Stability of frozen ceftriaxone
Ceftriaxone in 5% dextrose 100 ml polyolefin infusion bags may be frozen and microwave thawed by two different procedures at 270 Watts and 800 Watts power without major changes affecting concentration. Storage at 2°C to 8°C of solution did not affect the stability of the solution for at least 44 days for the 270 Watts cycle and 56 days for the 800 Watts cycle.
Ref: EJHP-S 2006; 13, 3: 52-56.



30/01/2007
A new link has been added in the databases towards "Syringe driver"


26/01/2007
Stability of morphine/hyoscine admixture used in palliative care.
The admixture morphine hydrochloride (1.37 mg/ml >> 10 mg/ml) with hyscine-Nbutyl bromide diluted with 0.9% sodium chloride is stable for 15 days in polypropylene syringes at room temperature or at 4°C and protected from light.
Ref: Support Care Cancer 2005; 13, 4: 239-245.



23/01/2007
Stability of prostaglandin E1 in aqueous solutions.
The stability of prostaglandin E1 in physiological serum (NaCl) was assessed considering different factors. Results showed that PGE1 was stable during three months, pH=7, whenstored at 4°C.
Ref: EJHP-S 2005; 11, 2: 31-36.


19/01/2007
Stability of doxorubicine and vincristine (VAD regimen)
The mixture doxorubicine 1.4 mg/ml with vincristine 0.053 mg/ml is stable in 0.9 sodium chloride or 0.45 sodium chloride/2.5% dextrose for at least 7 days when stored at 8°C. A new, sensitive LC-MS technique in combinaison with UV/fluorescence confirmed these results.
Ref: EJHP-S 2006; 1: 10-12.



16/01/2007
Compatibility irinotecan/ leucovorin
Rapid degradation of irinotecan was observed in one mixture: irinotecan 0,30mg/ml and leucovorin 3.6 mg/ml. The concentrations of irinotecan were  91.5% after 30 minutes and 76.3% after 24 hours. It was concluded that irinotecan and leucovorin were physically  compatible and chemically stable only for a sufficient period of time to allow concurrent infusion via a Y-site.
Ref: Can J Hosp Pharm 2005; 58, 4: 212-222.



09/01/2007
Incompatibility of mycafungin
Micafungin injection 1.5 mg/ml in 0.9% sodium chloride injection is physically incompatible for 4 hours after simulated Y-site co-administration at room temperature with albumin human, amiodarone, cisatracurium, diltiazem, dobutamine, epinephrine, insulin human regular, labetalol, meperidine, midazolam, morphine sulphate, mycophenolate mofetil, nesiritide, nicardipine, octreotide, ondansetron, phenytoin sodium, rocuronium bromide, vecuronium bromide.
Ref : Int J Pharm compound 2006; 10, 3: 230-232.


05/01/2007
Stability of palonosetron/dacarbazine admixture
Palonosetron HCl is physically and chemically stable when mixed with dacarbazine during simulated Y-site administration. However palonosetron HCl and methyl prednisolone sodium sucinate are physically incompatible, their admixture resulting in precipitation of methylprednisolone.
Ref : Int J Pharm Compound 2006; 10, 3: 234-236.



02/01/2007
Stability of frozen pemetrexed
Pemetrexed is chemically stable for 90 days frozen at -20°C, substantial numbers of microparticulates formes in pemetrexed diluted in the infusion dsolutions in PVC bags upon long-term frozen storage. The avoidance of freezing pemetrexed solutions in  PVC bag sis therefore warranted.
Ref : Ann Pharmacother 2006 ; 40, 7 : 1289-1292.



29/12/2006
Stability of pemetrexed
Pemetrexed 2, 10 and 20 mg/ml is chemically stable for 2 days at room temperature and
31 days refrigerated in dextrose 5% injection and NaCl 0.9% injection. However, substantial numbers of microparticulates may form in pemetrexed diluted in the infusion solutions in PVC bags, especially during longer periods of refrigerated storage.
Ref : Ann Pharmacother 2006 ; 40, 6 : 1082-1085.



26/12/2006
Incompatibility furosemide - phenylephrine
The solutions of furosemide 4 mg/ml diluted in 5% glucose 5% or 0.9% sodium chloride  are incompatible with the solutions of 0.64 mg/ml  phenylephrine and 0.4 UI/ml  vasopressine. This information is in contradiction with those of Trissel.
Ref : Am J Health Syst Pharm 2006 ; 63 : 906-908.



22/12/2006
The website is now translated into 14 languages (Latvian has been included) !

19/12/2006
A new link has been added in the databases towards "Trissel's Calcium & Phosphate Compatibility in Parenteral Nutrition"



14/12/2006
Stability of kétorolac trométhamine
Ketorolac tromethamine (Taradyl®) in 5% dextrose infusion may be prepared, frozen in advance by a centralised intravenous admixture service then thawed before use, and the microwave power used for thawing in this study has no impact on the final long-term stability at 4°C at the two concentration (0.1 and 0.3 mg/ml) after 35 days.