Infostab is a non-profit making association under French law. The goal of the association is to promote the correct use of injectable drugs in hospital (preparation, administration, stability and compatibility).
The association publishes an international database of stabilities and compatibilities of injectable drugs, STABILIS, which is translated into 24 languages.
Currently, the Web site is mainly directed towards the aspects of stability and compatibility of injectable drugs with topical information, lists of publications and posters as well as links towards guidelines concerning stability studies, the sites of other databases or journals publishing on the subject.
Please send us any ideas for improving the site.
The president of Infostab
Dr. Jean Vigneron
News
09/03/2010 LC stability studies of voriconazole and structural elucidation of its major degradation product Adams, A.I.H., Gosmann, G., Schneider, P.H., Bergold, A.M.. Chromatographia Volume 69, Issue suppl. 2, June 2009, Pages S115-S122
02/03/2010 Analysis of the stability and microbiological safety of aznol saline gargle in hospital preparations widely used for the treatment of oral cancer patients with oral mucositis Ushiyama, M., Ikeda, R., Nitta, T., Tazitsu, Y., Miyawaki, A., Yamaguchi, T., Shimodouzono, Y., Ushinohama, K., Matsui, R., Sugihara, K., Nakamura, N., Yamada, K. Oral Therapeutics and Pharmacology Volume 27, Issue 3, December 2008, Pages 143-150
26/02/2010 Stability of Mesna in ReadyMed Infusion Devices Hassan Almoazen, Himanshu Bhattacharjee, Anthony C Samsa, and Steve Pate Ann Pharmacother 2010;44:224-225
23/02/2010 Long-term stability of tramadol chlorhydrate and metoclopramide hydrochloride in dextrose 5% polyolefin bag at 4°C. Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. J Oncol Pharm Practice 2009 ; 15: 195-200
19/02/2010 Concomitant administration of intravenous drugs in the ICU: evaluation of physico-chemical compatibilities. Humbert-Delaloye V, Voirol P, Gattlen L, Berger M, Pannatier A. Congress ESCP / GSASA, Geneva, 3-5 November 2009
16/02/2010 Stability of Mesna in ReadyMed Infusion Devices Hassan Almoazen, Himanshu Bhattacharjee, Anthony C Samsa, and Steve Pate Ann Pharmacother 2010;44:224-225
12/02/2010 Estabilidad del colirio de pilocarpina 2 % Martha Botet García; Caridad Margarita García Peña; Vivian Martínez Espinosa; Bárbara Moreno Correoso. Revista Cubana de Farmacia 2009 ; 43, 4 : 61-67
05/02/2010 Survey of Canadian Pharmacists’ Responses to Warnings of Potential Interactions Between Ceftriaxone and Calcium in IV Solutions. Harder CK, Hawbolt JJ. Can J Hosp Pharm 2009; 62, 6: 483-486
29/01/2010 Effect of freezing, long-term storage and microwave thawing on the stability of a mixture of diclofenac and sodium bicarbonate in glucose 5% polyolefin bags. François JH, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. Ann Pharm Fr 2009; 67: 427-432
26/01/2010 Compatibility and stability of parenteral analgesic admixtures for multimodal analgesia David Balayssac, Lise Badaroux, Céline Rodier, Valérie Sautou-Miranda, Jean Etienne Bazin, Jean Chopineau. EJHP Science 2009; 15, 4: 78-82
22/01/2010 Stability of preoperative cataract surgery gel in polycarbonate syringes. Bailey C, Aloumanis V, Walker B, Ben M, Mc Guire J, Vu N. Int J Pharm Compound 2009; 13, 6: 564-568
15/01/2010 Development and validation of a stability-indicating RP-HPLC method for assay of betamethasone and estimation of its related compounds. Qiang Fu, Minshan Shou, Dwight Chien, Robert Markovich, Abu M. Rustum Journal of Pharmaceutical and Biomedical Analysis 2010; 51: 617–625
12/01/2010 Compatibility of an injectable high strength oxycodone formulation with typical diluents, syringes, tubings, infusion bags and drugs for potential co-administration Selina Hines, Steve Pleasance. EJHP Practice 2009; 15, 5: 32-38
08/01/2010 Stabilité de solutions de bévacizumab en fonction de la température Morand K, paul M, Lahlou A, Blanchet B, Astier A. Service de Pharmacie-Toxicologie, APHP UMR CNRS 7054 CHU Henri Mondor 94010 Cr CHU Henri Mondor 94010 Créteil Poster presented at the SFPO Congress in October 2009 (French Society of Oncology Phamacists) This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
05/01/2010 Spironolactone oral suspension for paediatric use: preparation, stability study and clinical use. Bersani G, Crivelli A, Mignini L, Stancari A, Guarguaglini AM, Pugiolli C, Rodriguez L. Bologna - Italy 33rd SIFO National Congress, Colli Del Tronto - Italy 2nd October 2009. This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
01/01/2010 Compatibilité entre amiodarone, catecholamines et/ou nitroprussiate de sodium, administré en continu par voie veineuse aux soins intensifs adultes. Imesch G., Humbert-Delaloye V., Berger M., Pannatier A. GASA Congress Lucerne 2008
The Infostab team wishes you a Happy New Year 2010!
29/12/2009 Visible particulates in injections: A history and a proposal to revise USP General chapter injections Russell E. Madsen, Roy T. Cherris, John G. Shabushnig, and Desmond G. Hunt Pharmacopeil Forum 2009; 35, 5: 1383-1387
22/12/2009 Preparation of 0.05% FK506 suspension eyedrops and its pharmacokinetics after topical ocular administration. Yuan J, Zhai JJ, Chen JQ, Ye CT, Zhou SY. J Ocul Pharmacol Ther. 2009 Aug;25(4):345-50
18/12/2009 Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes. Pascuet E, Donnelly RF, Garceau D, Vaillancourt R. Can J Hosp Pharm 2009; 62, 5: 375-380
15/12/2009 The Infostab/Stabilis website: a tool for oncology pharmacists Vigneron J. EJOP 2009 ; 3, 2 : 12
11/12/2009 Evaluation of the stability of morphine sulphate in combination with Instillagel®. Abdelmageed R, Labyad N, Watson DG, Pournamdari M, Cable CG, Stanley E. J Clin Pharm Ther 2009; 33, 3: 263-271
08/12/2009 Valutazione della stabilità chimico-fisica e microbiologica del collirio isotonico di voriconazolo. S. Giorgi(1), A. D’arpino(2), C. La Rosa(3), R. Meucci(1), A. Garaffi(1), I. Corti(1), M.G. Rossetti(1) S. Giorgi(1), A. D’arpino(2), C. La Rosa(3), R. Meucci(1), A. Garaffi(1), I. Corti(1), M.G. Rossetti(1) 1.Area galenica U.O.C. Farmacia, Azienda Ospedaliera Senese - Siena; 1.Area galenica U.O.C. Farmacia, Azienda Ospedaliera Senese - Siena; 2. Assistenza Farmaceutica, azienda USL n. 4 -Terni; 2. Assistenza Farmaceutica, azienda USL n. 4 -Terni; 3.Farmaco Chimico tecnologico, facoltà di Farmacia Università di Siena – Siena. This poster was presented at the last congress of the Italian Society of Hospital Pharmacists (SIFO) in october 2009. This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
04/12/2009 Anticorpi monoclonali: valutazione della stabilità microbiologica e chimico-fisica di preparazioni utilizzatez in ambito ospedaliero. L. Bellante(1), F. Gasparrini(2), G. Guglielmi(1), E. M. Proli (1), L. Sabene(1), P. Simone (2), G. Viora( 1 Farmacia Ospedaliera, Policlinico Universitario A. Gemelli della U.C.S.C.-Roma (RM); 2 Dip. di Chimica e Tecnologie del Farmaco , Università degli studi “La Sapienza” -Roma (RM) Poster presented at the last SIFO Congress (Italian Society of Hospital Pharmacists) This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
01/12/2009 Mechanically-induced aggregation of the monoclonal antibody cetuximab A. Lahlou, B. Blanchet, M. Carvalho,M. Paul, A. Astier. Annales Pharmaceutiques Françaises (2009) This publication can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
24/11/2009 Etude de la stabilité de la solution commerciale d'irinotécan (Campto®) après prélèvements réitérés dans la même flacon. E. Huet, S. Roy, C. Hochart Hochart, A. Bellanger, R. Farinotti, , C. Fernandez Laboratoire d’Analyse du médicament – Unité de Pharmacie Clinique Oncologique - Service de Pharmacie GH Pitié-Salpêtrière. Poster presented at the last Congress of the french Society of Hospital Pharmacists (SFPO) in October 2009 This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
20/11/2009 Stabilité d'un anticorps monoclonal après reconstitution : le rituximab. E. Jaccoulet, S. Guirao, K. Morand, A. Astier, M. Paul. University Hospital of Créteil - France This poster has been presented at the SFPO Congress in Cannes - France October 2009 This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
17/11/2009 A validated stability-indicating RP-HPLC method for levofloxacin in the presence of degradation products, its process related impurities and identification of oxidative degradant Devi L, Chandrasekar KB. J Pharm Biomed Anal 2009 ; 50, 5 : 710-717
13/11/2009 Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets Farnaz Monajjemzadeh, Davoud Hassanzadeh , Hadi Valizadeh, Mohammad R. Siahi-Shadbad, Javid Shahbazi Mojarrad, Thomas A. Robertson, Michael S. Roberts. Eur J Pharm Biopharm 2009; 73: 404-413.
10/11/2009 Physicochemical stability of oxaliplatin in 5% dextrose injection stored in polyvinyl chloride, polyethylene, and polypropylene infusion bags Eiden C, Philibert L, Bekhtari K, Poujol S, Malosse F, Frédéric Pinguet F. American Journal of Health-System Pharmacy 2009; 66, 21: 1929-1933.
06/11/2009 Estabilidad del colirio de pilocarpina 2 % Martha Botet GarcíaI; Caridad Margarita García EspinosaIII; Bárbara Moreno CorreosoIV . Revista Cubana de Farmacia. 2009; 43, 4: 61-67.
16/10/2009 Stability of extemporaneously prepared voriconazole ophthalmic solution Daoud Al-Badriyeh, Jian Li, Kay Stewart, David C. M. Kong, Lok Leung, Geoffrey E. Davies, and Robert Fullinfaw Am J Health Syst Pharm 2009 66: 1478-1483
13/10/2009 Stability of docetaxel diluted to 0.3 or 0.9 mg/mL with 0.9% sodium chloride injection and stored in polyolefin or glass containers Ana Aragones Eroles, Irene Mangues Bafalluy, and Joan Antoni Schoenenberger Arnaiz Am J Health Syst Pharm 2009 66: 1565-1568
09/10/2009 Stability of an extemporaneous oral liquid aprepitant formulation L. Lee Dupuis, Karen Lingertat-Walsh and Scott E. Walker Support Care cancer 2009; 17: 701-706
06/10/2009 Stability of alemtuzumab in infusion-bags M. Kupfer, G. Scriba and M. Hartmann Pharmazie 2009; 64, 9: 622-623
02/10/2009 Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC–MS and development of stability-indicating method Biljana Jocić, Mira Zečević, Ljiljana Živanović, Ana Protić, Milka Jadranin, Vlatka Vajs J Pharm Biomed Anal 2009 ; 50, 4 : 622-629
29/09/2009 A comparison of the stability of doxorubicin and daunorubicin in solid state J. Cielecka-Piontek, A. Jelińska, M. Zając, M. Sobczak, A. Bartold, I. Oszczapowicz J Pharm Biomed Anal 2009; 50, 4: 576-579
25/09/2009 Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine SV Mulgund, MS Phoujdar, SV Londhe, PS Mallade, TS Kulkarni, AS Deshpande, KS Jain Ind J Pharm Sci 2009 ; 71, 1 : 35-40
22/09/2009 Étude de stabilité d’une solution de céfuroxime pour injection intracamérulaire Bontemps C, Chataigner A, Sautou-Miranda V, Chopineau J. This poster was presented at the Hopipharm Congress In France. This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
15/09/2009 Hydromorphone and Dipyrone in PCA PCA-devices devices: Is this still a therapy with Hydromorphone? Simone Müller, Rainer Trittler, Rolf Schubert, Egid Strehl. University of Freiburg. 2nd PharmSciFair, Nice, 09. Juni 2009 This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
15/09/2009 Compatibility of levofloxacin injection and magnesium sulfate Mark G. Klang Am J Health Syst Pharm 2009 66: 1520
11/09/2009 Oxycodon-Metamizol in PCAPumpen- Kompatibel? Simone Müller, Rainer Trittler, Rolf Schubert. University of Freiburg Wissenschaftlicher Kongress der ADKA, Darmstadt 05. Juni 2009. This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
04/09/2009 Stability of gabapentin 300-mg capsules repackaged in unit dose containers Abhay Gupta, Anthony B. Ciavarella, Barry Rothman, Patrick J. Faustino, and Mansoor A. Khan Am J Health Syst Pharm 2009 66: 1376-1380
04/09/2009 Morphin-Haloperidol-Mischungen in PCA-Pumpen - Kompatibel? Rainer Trittler, Simone Müller, Mar Esteban University of Freiburg Wissenschaftlicher Kongress der ADKA, Darmstadt 05. Juni 2009 This poster can be downloaded by clicking in the menu in « Publications » and « Stability and compatibility ». With the authorization of the authors.
01/09/2009 Effect of freeze-thawing on the long-term stability of calcium levofolinate in 5% dextrose stored on polyolefin infusion bags. Lebitasy M, Hecq J.D, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L. J Clin Pharm Ther 2009 ; 34, 4 : 423-428
28/08/2009 Simultaneous quantification of water-soluble and fat-soluble vitamins in parenteral nutrition admixtures by HPLC-UV-MS/MS Raphaël Vazquez, My-Dung Le Hoang, Jean Martin, Yasmine Ait Yahia, Hervé Graffard, François Guyon, Bernard Do EJHP Science • Volume 15 • 2009 • Issue 2 • P. 28-35
25/08/2009 Incompatibility of imipenem–cilastatin and amoxicillin Bertrand Pourroy, Emilie Milano Bausset, Audrey Boulamery, Laurence Gauthier Villano, and Diane Braguer Am J Health Syst Pharm 2009 66: 1253-1254
21/08/2009 Test de compatibilités en laboratoire: Utilisation d'une méthode visuelle Humbert-Delaloye V, Berger M, Pannatier A. Congrès annuel de la GSASA, Lucerne, 20-21 novembre 2008. Can be downloaded onthe website of the University Hospital of Lausanne – Switzerland
18/08/2009 Stability indicating HPLC method for simultaneous determination of mephenesin and diclofenac diethylamine Mulgund S V, Phoujdar M S, Londhe S V, Mallade P S, Kulkarni T S, Deshpande A S, Jain K S. Ind J Pharm Sci 2009; 781, 1: 35-40
14/08/2009 Schmerzmittelreservoire : Stabilität binärer Opioid-Metamizol-Mischungen Simone Müller, Rainer Trittler, Herbert Bochow, Rolf Schubert, Egid Strehl University of Freiburg Der Deutsche Schmerz- und Palliativtag 2008, Frankfurt am Main 06. – 08. März 2008 This poster can be downloaded in "Publications" and "Stability and compatibility" With the permission of the authors
11/08/2009 One-year follow-up on procedure to prevent i.v. drug incompatibilities in an intensive care unit Thilo Bertsche, Linda Münk, Yvonne Mayer, Rebekka Stahl, Torsten Hoppe-Tichy, Jens Encke, and Walter Emil Haefeli Am J Health Syst Pharm 2009 66: 1250-1253
07/08/2009 Morphin-Metamizol-Mischungen zur kontinuierlichen parenteralen Applikation: Sind sie immer inkompatibel? Simone Müller1, Rainer Trittler1, Rolf Schubert2, Wilhelm Freiherr von Hornstein3, Egid Strehl1 University of Freiburg - Germany Poster presented at the ADKA Congress in May 2006 The poster can be downloaded in "Publication" and ""Stability and compatibility"
04/08/2009 Compatibilités entre amiodarone, cathécholamines et/ou nitroprussiate de sodium, administrés en continu par voie veineuses aux soins intensifs adultes. Imesch G, Humbert-Delaloye V, Berger M, Pannatier A. Congrès annuel de la GSASA, Lucerne, 20-21 novembre 2008. Can be downloaded on the website of the University Hospital of Lausanne – Switzerland
31/07/2009 Stability of Low-concentration ceftazidime in 0.9% sodium chloride injection and balanced salt solutions in plastic syringes under various storage conditions. Xu M, Warren F.W, Bartlett M.G. Int J Pharm Compound 2009; 13, 2: 166-169
21/07/2009 Information for hospital wards about the compatibility of parenteral drugs M C van Staveren; A Wieringa; T Visser EJHP Practice 2009; 15, 1; 64- 64
07/07/2009 Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and ketamine in infusion solutions. Hamdi M; Lentschener C; Bazin C; Ozier Y; Havard L. European Journal of Anaesthesiology 2009; 26, 1: 23-27
03/07/2009 Development and validation of a stability-indicating RP-HPLC method to separate low levels of dexamethasone and other related compounds from betamethasone Yuan Xiong, Kang Ping Xiao and Abu M. Rustum Journal of Pharmaceutical and Biomedical Analysis ; 49, 3 : 646-654
30/06/2009 Kétamine : Etude de stabilité d'une solution aqueuse buvable à 1 mg/ml. DUCHENE Marie-Laure*, DAURENJOU Magali*, LAVRUT Thibaut**, CARLES Danièle***, ALBERGE M.Claire****, LEONARDO Sandrine*, PEROUX Eliane* *Laboratoire de fabrication Pharmacie centrale, **Laboratoire de pharmacologie,***Laboratoire de bactériologie, ****Service de chirurgie infantile ; C.H.U. de Nice Poster presented during the last Synprefh Congress in Marseille - France - May 2009 The poster can be downloaded. See in the menu "Publications" and "Stability and compatibility" With the permission of the authors.
23/06/2009 Drug compatibility with a new generation of VISIV polyolefin infusion solution containers. Aloumanis V, Ben M, Kupiec T.C, Trissel L.A. Int J Pharm Compound 2009; 13, 2: 162-165
16/06/2009 Stability of Hydromorphone–Ketamine Solutions in Glass Bottles, Plastic Syringes, and IV Bags for Pediatric Use Ensom M.H.H, Decarie D, Leung K, MontgomeryC Can J Hosp Pharm 2009; 62, 2: 112-118
09/06/2009 Notice to Hospitals regarding Ceftriaxone–Calcium incompatibility: what’s a clinician to do? Gin A, Walker S. Can J Hosp Pharm 2009; 62, 2: 157-158
05/06/2009 Smart-pumps in the neonatal and pediatric intensive care unit: drug incompatibilities and occlusion alarms C. Fonzo-Christe , A. Kiener MSc, N. Bochaton Nurse, P. Regard Engineer, P. Rimensberger ,P. Bonnabry. This poster was presented at the ESCP / ACCP Congress in Orlando April 2009. It can be downloaded on the website of the University Hospital of Geneva
02/06/2009 Etude de stabilité du céfuroxime dansune solution d'irrigation oculaire Peynaud D, Poy L, Goujon P, Jolivet A, Leboucher G. University Hospital Lyon - France This poster was presented during the XII Congress of the French Society of Clinical Pharmacy. Saint-Malo FRANCE February 2008 It can be downloaded in the menu publications" and "Stability and compatibility" With the autorization of the authors.
29/05/2009 Extended Stability of Pantoprazole for Injection in 0.9% Sodium Chloride or 5% Dextrose at 4°C and 23°C Scott E Walker, John Iazzetta, Shirley Law Can J Hosp Pharm 2009; 62, 2: 135-141
26/05/2009 Physical Compatibility and Chemical Stability of Ketamine–Morphine Mixtures in Polypropylene Syringes Ronald F Donnelly Can J Hosp Pharm 2009; 62(1): 28–33
22/05/2009 Long-term stability of an aqueous solution containing lidocaine hydrochloride, dexamethasone sodium phosphate and adrenaline hydrochloride for electromotive administration. Vonbach P, Angelika H, Dibied A EJHP Science 2009; 15, 1: 6-10
19/05/2009 Information for hospital wards about the compatibility of parenteral drugs. Van Staveren M.C, Wieringa A, Visser T EJHP Practice 2009; 15, 1: 64
15/05/2009 The effect of nimodipine, fentanyl and remifentanil intravenous products on the stability of propofol emulsions Nemec K, Germ E, Schulz-Siegmund M, Ortner A. Pharmazie 2009; 64, 2: 94-97
12/05/2009 Stability of oxaliplatin solution Audrey Junker, Sandrine Roy, Marie-Catherine Desroches, Clotilde Moussay, Malik Berhoune, Agnès Bellanger, Christine Fernandez, and Robert Farinotti Ann Pharmacother 2009;43:390-391
08/05/2009 Stability of antineoplastic agents in use for home-based intravenous chemotherapy. Frédéric Benizri, Brigitte Bonan, Anne-Laure Ferrio, Marie-Laure Brandely, Vincent Castagné, Nathalie Théou-Anton, Muriel Verlinde-Carvalho and Laurent Havard Pharmacy World & Science 2009 Volume 31, Number 1: 1-13
05/05/2009 Stability of cyclosporine eye drops Cécile Bontemps, Amandine Rougeron, Valérie Sautou-Miranda, Anne Boyer, Jean Chopineau. Poster presented at ESCP Congress Dubrovnik, Croatia 21 -24 October 2008 The poster can be downloaded. See in "Publications" and "Stability and compatibility" With the authorization of the authors.
01/05/2009 Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration Laurence Galanti, Massin P Lebitasy, Jean-Daniel Hecq, Julie Cadrobbi, Danielle Vanbeckbergen, and Jacques Jamart Can J Hosp Pharm 2009; 62(1): 34–38
28/04/2009 Chemical stability of a solution of bupivacaine hydrochloride 0.125% and sufentanil citrate 0.5 µg/ml for filling syringes using a repeater pump. Janssen K, Wisselo R, Geerlings C, Schouten J.P. EJHP Science 2009; 15, 1: 11-14
17/04/2009 Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing Tze-Ming Chan, Birendra Pramanik, Robert Aslanian, Vincent Gullo, Mahesh Patel, Bart Cronin, Chris Boyce, Kevin McCormick, Mike Berlin, Xiaohong Zhu, Alexei Buevich, Larry Heimark, Peter Bartner, Guodong Chen, Haiyan Pu, Vinod Hegde. Journal of Pharmaceutical and Biomedical Analysis 49 (2009) 327–332
14/04/2009 Development and stability testing of a concentrated injectable clonidine solution for intrathecal analgesia. Hollenwaeger M, Borquin Challandes I, Fallab L.C, Schaad N, Zelger G. EJHP Science 2008; 15, 1: 3-5
07/04/2009 Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate. Cadrobbi J, Hecq J.D, Vanbeckbergen D, Jamart J, Galanti L. EJHP Science 2009; 15, 1: 15-19
03/04/2009 Compatibility and stability of analgesic admixtures for parenteral use: paracetamol, ketoprofen and tramadol. Lise Badaroux, Céline Rodier, David Balayssac ,Valérie Sautou-Miranda, Jean Chopineau CHU Gabriel Montpied, Clermont-Ferrand, France This poster was presented at the ESCP Congress in Edinburgh May 2007 Can be downloaded in "Publication" and "Stability and compatibility" With the permission of the authors
31/03/2009 In vitro stability of lyophilized and reconstituted recombinant activated factor VII formulated for storage at room temperature Hanne Nedergaard, Susanne Vestergaard, Pernille Theil Jensen, Morten Wagner Kristiansen, Michael Bech Jensen, Per B. Østergaard, Tina Norsell, Jens Bjerre Clinical Therapeutics, Volume 30, Issue 7, July 2008, Pages 1309-1315
24/03/2009 In vitro stability of two formulations of recombinant activated factor viia reconstituted in inappropriate solvents or at inappropriate volumes Britt Petersson, Anna B. Schönwandt, Preben Þstfeldt, Hanne Nedergaard, Michael Bech Jensen, Per B. Þstergaard, Tina Norsell, Jens Bjerre Clinical Therapeutics, Volume 30, Issue 5, May 2008, Pages 917-923
20/03/2009 Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion. Kambia N.K, Luyckx M, Dine T, Dupin-Spriet T, Gressier B, Brunet C. Journal of Clinical Pharmacy and Therapeutics (2009) 34, 25–31
17/03/2009 Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride Ch. Bharathi, P. Jayaram, Joseph Sunder Raj , M. Saravana Kumar, V. Bhargavi , V.K. Handa, Ramesh Dandala, A. Naidu. Journal of Pharmaceutical and Biomedical Analysis 48 (2008) 1211–1218
13/03/2009 Précipitation du phosphate de calcium dans les nutritions parentérales : avantages des sels organiques Bouchoud Bertholet L, Sadeghipour F, Fonzo-Christe C, Bonnabry P Congrès GSASA, Lucerne, 20-21.11.2008 Can be downloaded on the website of University Hospital of Geneva
10/03/2009 Long term physico-chemical stability of standard parenteral nutrition for neonates Bouchoud Bertholet L, Sadeghipour F, Fonzo-Christe C, Pfister R, Bonnabry P 30th Espen Congress, Florence 2008 Can be downloaded on the website of University Hospital of Geneva
06/03/2009 Release of a plasticizer. tri-2-ethylhexyl trimellitate from polyvinylchloride tubings Sophie Trevis. Valérie Sautou-Miranda. Sandrine Bagel-Boithias. David Balayssac. Jean Chopineau. This poster was presented at the ESCP Congress in Edinburgh mai 2007 See in the menu "Publication" and "Stability and compatibility" to download the poster.
03/03/2009 Stability and compatibility of drug mixtures in an implantable infusion system. Bianchi F, Ginggen A, Tardy Y. Anaesthesia. 2008 Sep;63(9):972-8
27/02/2009 Guidelines for stability testing of pharmaceutical products containing well established drug substances in conventional dosage forms. This document can be downloaded on the website of WHO World Health Organization
24/02/2009 Stability testing of pharmaceutical products in a global environnement. Sabine Kopp This document can be downloaded on the website of WHO World Health Organization
13/02/2009 Incidents de perfusion aux soins intensifs de pédiatrie : existe-t-il un lien entre les alarmes d'occlusion et des incompatibilités médicamenteuses ? Amalys Kiener This document can be downloaded on the website of University Hospital of Geneva
10/02/2009 Stabilité des formulations injectables de lidocaïne en présence de bicarbonate de sodium : mise en place d'une procédure pour les unités de soins. Fleury Souverain S, De Giorgi I, Evard T, Bonnabry P Congrès GSASA & 14èmes JFSPH, Lausanne, 14-16 novembre 2007 Can be downloaded on the website of University Hospital of Geneva
06/02/2009 Release of di(2-ethylhexyl)phtalate from polyvinylchloride bags during docetaxel infusions Sandra BOURLON (1), Valérie SAUTOU-MIRANDA (1,2), Murielle DALLE (1), David BALAYSSAC (1), Jean CHOPINEAU (1,2) (1) Department of Pharmacy, G. Montpied Hospital, Clermont-Ferrand, France Poster presented at the ESCP Congress in STockholm 2005 Can be downloaded in "Publications" and "Stability and compatibilities"
03/02/2009 Comparative evaluation of eight tools to prevent drug incompatibilities De Giorgi I, Guignard B, Fonzo-Christe C, Bonnabry P 37th ESCP Congress, Dubrovnik, 22-24.10.2008 Can be downloaded on the website of University Hospital of Geneva
30/01/2009 Chemical stability of admixtures containing ziconotide 25 mcg/ml and morphine sulfate 10 mg/ml or 20 mg/ml during simulated intrathecal administration. Shields D.E, Aclan J, Szatkowski A. Int J Pharm Compound 2008 ; 12, 6: 553-557
27/01/2009 Physical compatibility and chemical stability of a concentrated solution of atropine sulfate (2 mg/ml) for use as an antidote in nerve agent casualties. Donnelly R.F, Corman C. Int J Pharm Compound 2008 ; 11, 6: 550-552
16/01/2009 Allen LV, Okele CC. Basics of compounding : Considerations for implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding – Sterile preparations, part 8: Stability and Beyond-Use dating. Int J Pharm Compound 2008; 12, 4: 344-353
09/01/2009 Development of ready-to-use ketamine hydrochloride syringes for safe use in post-operative pain. Stucki MC, Leury-Souverain S, Sautter AM, Sadeghipour F, Bonnabry P. EJHP Science 2008; 14, 1: 14-18
05/01/2009 Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles Brustugun J, Lao YE, Fagernæs C, Brænden J, Kristensen S. Am J Health Syst Pharm 2009 66: 1722-1725
02/01/2009 Stability of Magnesium Sulfate 20% in Viaflex Bags Brandi D Newby, Cindy Benes, Lynne Palmer, and Richard Cleve Can J Hosp,Pharm 2008; 61, 5
30/12/2008 Durée de stabilité de médicaments en seringue pour administration sous-cutanée à des patients en fin de vie à domicile. Annie Roberge, Julie Couture, Michel Tassé, Myreille Goulet, Robert Thiffault, Manon Hanna, Chantal Tremblay, Michèle Plante, Brigite Naud, Pierre-Richard Couture Pharmactuel 2008 ; 41, 4 : 230-236
23/12/2008 Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances. Yimei Baob, Xiaopeng Mob, Xiaoying Xub, Yuyu Heb, Xiao Xua, Haoyun Ana. Journal of Pharmaceutical and Biomedical Analysis 2008; 48: 664–671
19/12/2008 Stability of alprostadyl solution in polypropylene syringes This poster was presented during the APHIF Congress in November 2008 KACEM Balsam, CARVALHO Muriel, LAHLOU Amine, GAUDOIN Anne, YIOU René, ASTIER Alain, PAUL Muriel. University Hospital of Créteil – France The poster can be freely downloaded. See in « Publications » and « Stability and compatibility »
16/12/2008 Cefepime Stability in IV Solutions and Admixtures Christianne M Zaki, Nagia N Afifi, and Hanaa Aba El Moneim Can J Hosp,Pharm 2008; 61, 5
12/12/2008 Short-term physical compatibility of intramuscular aripiprazole with intramuscular lorazepam Lawrence J. Kovalick, Andrei A. Pikalov, III, Nina Ni, Vijay H. Naringrekar, and Robert D. McQuade Am J Health Syst Pharm 2008 65: 2007-2008
09/12/2008 Chemistry and safety of phosphates injections David W. Newton and David F. Driscoll Am J Health Syst Pharm 2008 65: 1761-1766
02/12/2008 Compatibility and Aerosol Characteristics of Formoterol Fumarate Mixed with Other Nebulizing Solutions Samuel Akapo, June Gupta, Eloisa Martinez, Chithra McCrea, Liwen Ye, Mark Roach. The Annals of Pharmacotherapy: 2008; 42, 10:1416-1424.
18/11/2008 Handbook of injectable drugs 15th edition is now available. The database contains 359 drugs and 2723 references, 100 new to this edition. Can be ordered on ASHP website
14/11/2008 Information about the stability of oncology drugs: the hospital pharmacist’s role. J Vigneron. EJHP – ESMO Supplement 2008 : 15-17.
07/11/2008 Physical and chemical stability of palonosetron hydrochloride with glycopyrrolate and neostigmine during simulated Y-site administration. Ben M, Trusley C, Kupiec TC, Trissel LA. Int J Pharm Compound 2008. 12, 4: 368-371.
31/10/2008 Chemical stability of admixtures combining ziconotide with fentanyl or sufentanil during simulated intrathecal administration. Shields DE, Aclan J, Szatkowski A. Int J Pharm Compound 2008 ; 12, 5: 463-466.
28/10/2008 Stability of proteins in aqueous solution and solid state S Jacob, AA Shirwaikar, KK Srinivasan, J Alex, SL Prabu, R Mahalaxmi, Ravi Kumar Ind J Pharm Sci 2006; 68, 2: 154-163.
24/10/2008 Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients Stephanie J. Wallace, Jian Li, , Craig. R. Rayner, Kingsley Coulthard,and Roger L. Nation, Antimicrobial Agents Chemother, 2008; 52, 98: 3047-3051.
21/10/2008 Compatibility and stability of palonosetron hydrochloride with lactated Ringer's, Hetastarch in lactated electrolyte, an mannitol injections during simulated Y-site administration. Ben M, Kupiec T, Trusley C, Trissel LA. Int J Pharm Compound 2008 ; 12, 5: 460-462.
23/09/2008 Stability of metoprolol tartrate injection 1 mg/mL undiluted and 0.5 mg/mL in 0.9% sodium chloride injection and 5% dextrose injection. Kraft MD, Johnson CE, Chung C, Julian F Am J Health Syst Pharm. 2008 Apr 1;65(7):636-8
19/09/2008 Physical and Chemical Stability of Esomeprazole Sodium Solutions (September) Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, Lawrence A Trissel Pak Chan, Joe Patterson. Ann. Pharmacother., Jul 2008
12/09/2008 Compatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administration Pak Chan, Amanda Bishop, Thomas C. Kupiec, Lawrence A. Trissel, Dilip Gole, Ilias M. Jimidar and Hans Vermeersch American Journal of Health-System Pharmacy, Vol. 65, Issue 16, 1545-1551
09/09/2008 Chemical Stability of Admixtures Combining Ziconotide With Baclofen During Simulated Intrathecal Administration David Shields, Rick Montenegro, Jennifer Aclan Neuromodulation 2007 ; 10 : 12-17.
05/09/2008 Statistical Evaluation of the Chemical Stability of Ziconotide Solutions During Simulated Intrathecal Administration David E. Shields PhD, Wei Liu PhD, Kevin Gunning BA and Rick Montenegro. Journal of Pain and Symptom Management 2008;36, Issue 1: e4-e6
29/08/2008 Compatibility of doripenem with other drugs during simulated Y-site administration Matthew K. Brammer, Pak Chan, Kathy Heatherly, Craig Trusley, Thomas C. Kupiec, Lawrence A. Trissel, Petros A. Psathas, Timothy Gilmor and Daniel Schaufelberger American Journal of Health-System Pharmacy 2008, Vol. 65, Issue 13, 1261-1265
26/08/2008 Stabilité et compatibilité de l’association ondansétron–méthylprednisolone en solution Christine Fernandez, Anne Pelloquin, Malik Berthoume, Agnes Bellanger et Robert Farinotti Can J Hosp Pharm 2008 ; 61, 3 .
22/08/2008 Stability and Analgesic Efficacy of Di-acetyl Morphine (Diamorphine) Compared with Morphine in Implanted Intrathecal Pumps In Vivo Jon H. Raphael, MD; Stephen M. Palfrey, MCB; Arasu Rayen, FRCA; Jane L. Southall, RN; Maurad H. Labib, FRCPath Neuromodulation 2004 ; 7, 3 : 197-200.
12/08/2008 Chemical Stability of Admixtures Combining Ziconotide with Morphine or Hydromorphone During Simul ated Intrathecal Administration David Shields, PhD Rick Montenegro, BS Matthew Ragusa, BA Neuromodulation 2005 ; 8, 4 : 257-263.
08/08/2008 Evaluation of the stability of morphine sulphate in combination with Instillagel® R. Abdelmageed , N. Labyad , D. G. Watson, M. Pournamdari, C. G. Cable E. Stanley. J Clin Pharm Ther 2008; 33, 3: 263-271.
05/08/2008 A new poster on the stability of oxaliplatine is available. See "Publications" and "Stability and compatibility" to download the document.
01/08/2008 Stability of lyophilized human growth hormone Maya S. Salnikova, C. Russell Middaugh, J. Howard Rytting Int J Pharm 2008; 358, 1-2 : 108-113
29/07/2008 Chemical Stability of Ziconotide-Clonidine Hydrochloride Admixtures With and Without Morphine Sulfate During Simulated Intrathecal Administration David Shields, Rick Montenegro Neuromodulation 2007 ; 10 : 6-11.
22/07/2008 Chemical Stability of an Admixture Combining Ziconotide and Bupivacaine During Simulated Intrathecal Administration David Shields, Rick Montenegro, Jennifer Aclan Neuromodulation 2007 ; 10 : 1-5.
18/07/2008 Paul M, Lahlou A, Carvalho M, Blanchet B, Astier A. Thermal stability of two monoclonal antibodies : cetuximab and bevacizumab. EJOP 2008 ; 2, 1 : 37.
15/07/2008 Formulation and thermal sterile stability of a less painful intravenous clarithromycin emulsion containing vitamin E Pages 47-56 Yan Lu, YanJiao Wang and Xing Tang Int J Pharm 2008; 546+, 1-2: 47-56.
11/07/2008 Anti-Xa Stability of Diluted Dalteparin for Pediatric Use Neil A Goldenberg, Linda Jacobson, Hannah Hathaway, Mark Tripputi, Judy Primeaux, Jason Child Ann of Pharmacother2008, 42, 4: 511-515
08/07/2008 Stability of cefuroxime in BSS solution. This new poster was presented at the XII Congress of the French Sociiety of Clinical Pharmacists in February 2008 (Saint malo - France) The poster can be downloaded. See in "Publication" and "Stability and compatibility" With the authorization of the authors.
01/07/2008 Improving the stability of potassium clavulanate in admixture with amoxicillin By Elena M. Vega, BSc, PhD, Ruben H. Manzo, BSc, PhD and Nancy Sola, BSc, PhD Hospital Pharmacist 2008;15:183-185
24/06/2008 Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders Jichao Kang, Oliver Lambert , Michael Ausborn and Steven P. Schwendeman International Journal of Pharmaceutics 2008, 357, 1-2: 235-243.
17/06/2008 Stability of Levalbuterol in a Mixture of Levalbuterol and Ipratropium Nebulizer Solution Weeranuj Yamreudeewong, M. Glaucia Teixeira, and Gabriele E. Mayer Hosp Pharm 2008; 43: 303-306.
13/06/2008 Physicochemical Stability of Parenteral Nutrition Supplied as All-in-One for Neonates Maria Skouroliakou, Chrysoula Matthaiou, Antonia Chiou, Demosthenes Panagiotakos, Antonis Gounaris, Tony Nunn and Nikolaos Andrikopoulos. Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 2, 2008 201-209
10/06/2008 Two news poster on the stability of cytotoxic drugs can be downloaded . See in "Publications" and "Stability and compatibility"
06/06/2008 Trusley C, Ben M, Kupiec TC, Trissel LA. Compatibility and stability of palonosetron hydrochloride with four neuromuscular blocking agents during simulated Y-site administration. Int J Pharm Compound 2008; 12, 2: 156-160.
03/06/2008 Kupiec T, Ben M, Trusley C, Trissel LA. Compartibility and stability of palonosetron hydrochloride with gentamicin, metronidazole, or vancomycin during simulated Y-sirte administration. Int J Pharm Compound 2008; 12,2: 170-173.
30/05/2008 Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization Jiaher Tian , Valentino J. Stella. J Pharm Sci 2008; 97, 3: 1224-1235.
27/05/2008 Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection Raf De Jongh1, Ria Hens1, Violetta Basma2, Johan W. Mouton3, Paul M. Tulkens2,* and Stéphane Carryn2 J Antimicrob Chemother 2008 ; 61, 2 : 382-388.
23/05/2008 Gupta V.D. Chemical stability of tramadol hydrochloride injection. Int J Pharm Compound 2008; 12, 2: 161-162.
20/05/2008 Stability of TPN: influence of electrolytes You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Stabilité des TPN: influence des électrolytes » http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm
16/05/2008 Stability of Bortezomib Reconstituted with 0.9% Sodium Chloride at 4°C and Room Temperature (23°C) Scott E Walker, Debbie Milliken, and Shirley Law Can J hosp Pharm 2008; 61, 1
13/05/2008 Chemical stability of haloperidol injection by high performance thin-layer chromatography Sigrid Mennickent, Loreto Pino , Mario Vega , Marta de Diego J Sep Sci 2008 ; 31, 1 : 201-206.
09/05/2008 Risks associated to injectable drugs You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Risques liés aux médicaments injectables » http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm
06/05/2008 Total parenteral nutrition – problems in compatibility and stability Allan Mikael Schroder EJHP Practice 2008; 14, 1: 65-67.
25/04/2008 Study of protein conformational stability and integrity using calorimetry and FT-Raman spectroscopy correlated with enzymatic activity A.A. Elkordy , a, , R.T. Forbesa and B.W. Barrya Eur J Pharm Sci 2008; 33, 2: 177-190.
22/04/2008 Calcium and phosphate compatibility: Revisited again David W. Newton and David F. Driscoll Am J Health Syst Pharm 2008 65: 73-80.
18/04/2008 Strategy for identification of leachables in packaged pharmaceutical liquid formulations Changkang Pan, Ferris Harmo, Karen Toscano, Frances Liu and Richard Vivilecchia J Pharm Biomed Anal 2008; 46, 3: 520-527.
15/04/2008 A new poster can be freely downloaded. See "Publications" and "Stability and compatibility" Comparative of different intravenous infusion containers. This poster was presented at the 10th Congress of the European Association of Hospital Pharmacists. Lison, Portugal, 16-18 March 2005.
04/04/2008 Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids Journal of Separation Science 2006 ; 29, 11 : 1550-1560.
01/04/2008 Tiffany Derrick, Adeola O. Grillo, Samadhi N. Vitharana, LaToya Jones, Jason Rexroad, Ambarish Shah, Melissa Perkins, Thomas M. Spitznagel, C. Russell Middaugh. Effect of polyanions on the structure and stability of repiferminTM (keratinocyte growth factor-2) J Pharm Sci 2007; 96, 4: 761-776.
28/03/2008 Frederic Adnet, Laurence Le Moyec, Charles E Smith, Michel Galinski, Patricia Jabre1, Frederic Lapostolle Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy Emergency Medicine Journal 2007;24:168-169
25/03/2008 Kupiec Thomas C, Skinner Rodney, Lanier Lance Quality-Control Analytical Methods: Stability Versus Potency Testing: The Madness is in the Method Int J Pharm Compound 2008 ; 12, 1 : 50-53
21/03/2008 Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin - EDM Research Series N° 08 On WHO website
18/03/2008 Roberto Sacco, Giovanna Sacchetto, Mirella Francalanci, Cinzia Boselli Studio di stabilità chimico-fisica di una formulazione per la terapia antalgica a base di levobupivacaina e fentanyl Bolletino SIFO 2-2006
11/03/2008
Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T, Forest Jean-Marc, Hildgen Patrice Room Temperature Stability of Injectable Succinylcholine Dichloride Int J Pharm Compound 2008 ; 12, 1 : 83-85.
07/03/2008 Cristiana Romanazzi, Stella Sferra, Anna Campi, Barbara Rabino, Marco Barbieri, Sofia Castellani, Luana Sabbatini, Paola Scanavacca Dexrazoxane: stabilità in soluzione Bolletino SIFO 2007;53 ,4 : 178-180
04/03/2008 Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis Journal of Separation Science 2006 ; 29, 11 : 1550-1560.
29/02/2008 Stabilis online ! Click on "Stabilis" on the left side on the screen and then click on the button "Stabilis" By choosing "List of drugs", you have access to 374 monographs of injectable drugs with informations on stability in solutions, in admixtures, incompatibilities ...
26/02/2008 A Comparison of Plasticizers for Use in Flexible Vinyl Medical Products Data from three studies suggest that using trimellitates can reduce the amount of plasticizer that may migrate from PVC devices. Richard C. Adams Medical Device Link dec 2007
22/02/2008 Diethylhexylphthalate Extracted by Typical Newborn Lipid Emulsions From Polyvinylchloride Infusion Systems Causes Significant Changes in Histology of Rabbit Liver P. D. Steffan Loff, Ulrike Subotic, Jasmina Oulmi-Kagermann, Bettina Kränzlin, Maria-Franziska Reinecke and Christiane Staude Journal of Parenteral and Enteral Nutrition, Vol. 31, No. 3, 2007 188-193
19/02/2008 New links to articles or posters have been placed into the list "Stability and compatibility". See "Publications" and "Stability and compatibility".
11/02/2008 STABILIS online ! The database STABILIS is now available on the website. You have to choose "Stabilis" on the menu at the left side of the screen. The database contains important improvements like a general search function, a search function for incompatibilities, possibility to create a pdf file for each monograph etc. Don't hesitate to give your opinion about the new Stabilis database by using the email adress : infostab@wanadoo.fr
22/01/2008 Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A Int J Pharm Compound 2007; 11, 6: 520-524.
18/01/2008 Tracking of the Kinetic Stability of 2 Types of Total Nutrient Admixtures Containing Different Lipid Emulsions Judit Balogh, Dorottya Kiss, Judit Dredán, István Puskás, Ferenc Csempesz, and Romána Zelkó AAPS PharmSci. 2006; 7(4)
15/01/2008 A rapid technique to evaluate the oxidative stability of a model drug. Felton LA, Yang J, Shah K, Omidian H, Rocca JG Drug Dev Ind Pharm 2007 Jun; 33(6):683-9.
15/01/2008 Stability of 70% alcohol solutions in polypropylene syringes for use in ethanol-lock therapy Mary Petrea Cober and Cary E. Johnson Am J Health Syst Pharm 2007; 64, 23: 2480-2482.
11/01/2008 Evaluation of the chemical compatibility of plastic contact materials and pharmaceutical products; safety considerations related to extractables and leachables Dennis Jenke * J Pharm Sci 2007; 96, 10: 2566-2581.
08/01/2008 Stability of vecuronium in sterile water for injection stored in polypropylene syringes for 21 days Cary E. Johnson and Mary Petrea Cober Am J Health Syst Pharm 2007; 64, 22: 2356-2358.
04/01/2008 de Diego M, Godoy G, Mennickent S Chemical stability of midazolam injection by high performance liquid chromatography. J Sep Sci 2007 Jun 12.
01/01/2008 Compatibility and stability of tramadol and dexamethasone in solution and its use in terminally ill patients S. Negro, A. Salam, Y. Sánchez, M. L. Azuara, E. Barcia. J Clin Pharm Ther 2007; 32, 5: 441-444.
28/12/2007 Amélioration des pratiques d’administration des antibiotiques injectables : proposition et évaluation d’un guide de compatibilité physico-chimique (in french) A Camut, V Noirez, B Gustin, A Khalife J Pharm Clin 2007; 26, 3: 143-150.
25/12/2007 Accelerated aging: Prediction of chemical stability of pharmaceuticals Kenneth C. Waterman , and Roger C. Adami Int J Pharm 2005; 293, 1-2: 101-125.
21/12/2007 A Four-Column Approach to Developing Stability-Indicating HPLC Methods This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients. LCGC North America, Jun 1, 2002
18/12/2007 Liposomal amphotericin B eye drops to treat fungal keratitis: Physico-chemical and formulation stability K. Morand, A.C. Bartoletti, A. Bochot, G. Barratt, M.L. Brandely and F. Chast Int J Pharm 2007; 334, 1-2: 150-153.
14/12/2007 Influence du stress mécamique sur la stabilité du bévacizumab. (in french) Lahlou, Blanchet B, Carvalho M, Astier A, Paul M. Presented at the SFPO Congress in Nice (october 2007) Can be downloaded. See "Publications" and "Stability and compatibility" With the authorization of the author.
11/12/2007 Liposome formulation of Paclitaxel with enhanced solubility and stability. Yang T, Cui FD, Choi MK, Lin H, Chung SJ, Shim CK, Kim DD Drug Deliv 2007 Jun; 14(5):301-8.
07/12/2007 Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion. Tian L, He H, Tang X J Pharm Sci 2007 May 14.
04/12/2007 Stabilité thermique de 2 anticorps monoclonaux : bevacizumab et cetuximab. (in french) Paul M, Lahlou A, Carvahlo M, Blanchet B, Astier A. Presented at the SFPO Congress in Nice (october 2007) Can be downloaded. See "Publications" and "Stability and compatibility" With the authorization of the author.
30/11/2007 Stability of Docetaxel Solution after Dilution in Ethanol and Storage in Vials and after Dilution in Normal Saline and Storage in Bags. Scott E Walker, Flay Charbonneau, and Shirley Law Can J Hosp Pharm 2007; 60, 5: 217-284.
27/11/2007 Are monoclonal antibody stable ? (in french) Pr Alain ASTIER Presented at the SFPO Congress in Nice (october 2007) Can be downloaded. See "Publications" and "Stability and compatibility" With the authorization of the author.
23/11/2007 A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate 'dose-banding'. Kaestner S, Sewell G. In this study, the authors have demonstrated that carboplatine infusions could be stored refrigerated for 84 days. J Oncol Pharm Practice 2007; 13: 119-126.
20/11/2007 Examination of stability and compatibility of flucloxacillin (Floxapen®) and ceftazidime (Fortum®) in two infusion media: relevance for the clinical praxis. Florian Thalhammer, Alexandra Maier-Salamon und Walter Jäger. Wien Med Wochenschr 2005 ; 155 (13-14) : 337-343.
16/11/2007 Compatibility of insulin over 24 hours in standard and bicarbonate-based peritoneal dialysis solutions contained in bags made of different materials. Voges M, Divino-Filho JC, Faict D, Somers F, Vermeulen P. Perit Dial Int 2006 Jul-Aug; 26(4) :498-502.
09/11/2007 Physicochemical stability of lipid injectable emulsions: Correlating changes in large globule distributions with phase separation behavior. Thomas Gonyon, Pankaj Patel, Heather Owen, Andrew J. Dunham and Phillip W. Carter. Int J Pharm 2007; 343, 1-2: 208-219.
06/11/2007 Estabilidad de parecoxib en dilución con otros fármacos y administrado en perfusión continua IV para el control del dolor postoperatorio. Acín Lázaro MP, Bono Ariño C, Martínez Bazán R, Manzanares Marín I, Faci Bouthelier A, Velamazán Blocona MJ, Facorro Gaspar E, Sanz Gandasegui M, Aleploglian Barbarian K Investig. Clin. Farm. 2005, Vol. 2 (4): 195-203
02/11/2007 Stability of oxaliplatin in infusion bags containing 5% dextrose injection. Pascal André, Salvatore Cisternino, Anne-Lise Roy, Fouad Chiadmi, Joël Schlatter, Pascal Agranat, Olivier Fain and Jean-Eudes Fontan Conclusion. Oxaliplatin 0.7 mg/mL in infusion bags containing 5% dextrose injection was chemically stable for at least 30 days at both 3–7 °C and 20–24 °C without regard to light exposure. Am J Health-Syst Pharm,2007;64,18/1950-1954
30/10/2007 Use of microcalorimetry and its correlation with size exclusion chromatography for rapid screening of the physical stability of large pharmaceutical proteins in solution. Burton L, Gandhi R, Duke G, Paborji M Pharm Dev Technol 2007; 12(3) :265-73.
26/10/2007 Validation of an HPLC method for the analysis of decomposition products in injectable diazepam. Hudecová T, Bátorová V, Hatrík S, Havránek E Ceska Slov Farm 2004 Sep; 53(5) :228-33.
23/10/2007 Compatibility and stability of furosemide and dexamethasone combined in infusion solutions. Negro S, Rendon AL, Azuara ML, Sánchez Y, Fernández-Carballido A, Barcia E These results confirm the stability of mixtures prepared with sodium furosemide (< or = 120 mg/day) and dexamethasone sodium phosphate (< or = 40 mg/day) for a period of 5 days and with independence of their storage at 4 degrees C or 25 degrees C. Arzneimittelforschung 2006; 56(10) :714-20.
19/10/2007 Long-term stability of sodium folinate in dextrose 5% polyolefin bags at 4°C. Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. J Oncol Pharm Practice 2007; 13: 99-103.
16/10/2007 Shelf-lives of IV products — are there any limits? By Michael Allwood, PhD, FRPharmS and Graham Sewell, PhD, MRPharmS Hospital Pharmacist 2007;14:242
05/10/2007 A simulation study with statistical evaluation for the determination of non-isothermal kinetics conditions in drugs stability Eur J Pharm Sci; 2007; 31, 5: 277-287.
02/10/2007 Stability of an extemporaneously prepared recombinant human interferon alfa-2b eye drop formulation. Conclusion. An extemporaneously pre -pared rh-IFN- 2b eye drop formulation was stable at 5 ± 3 °C for 15 days and at 28 ± 2 °C for 7 days. Am J Health Syst Pharm; 64, 16: 1716-1719.
28/09/2007 Incompatibility reactions in iv drug therapy : Preventable medication errors. Presented by Pr Stefan Muhlebach, Bern, Switzerland during the EAHP congress in Bordeaux, France, march 2007. You can download the pdf file. See in "Publications" and "Stability and compatibility" With the authorization of the author.
25/09/2007 Incompatibility of iv drugs in daily practice : an underrecognised and underestimated problem. by Karin Nemec, PhD from Vienna, Austria Presented during the seminar "Incompatibility reactions in drug therapy – preventable medication errors" in the EAHP Congress in Bordeaux, France, march 2007. You can download the pdf file. See in "Publications" and "Stability and compatibility" With the authorization of the author
21/09/2007 Room-temperature storage of medications labeled for refrigeration. Conclusion. Information regarding the room-temperature storage of 79 medications labeled for refrigerated storage was compiled. Am J Health Syst Pharm 2007; 64, 16: 1711-1715.
18/09/2007 Viability of micro-organisms in novel anticancer drug solutions. Conclusion : Micro-organisms can survive in diluted solutions of antineoplastic drugs and proliferate when transferred to proper growth media. EJHP-Science 2007; 13, 2: 27-32.
14/09/2007 Development and validation of a simple HPLC method for simultaneous in vitro determination of amoxicillin and metronidazole at single wavelength. J Pharm Biomed Anal 2007; 43, 1: 325-329.
07/09/2007 Stability of a heparin-free 50% ethanol lock solution for central venous catheters. Thesefindings suggest that a 50% (v/v) ethanol solution stored in a syringe at room temperature, not protectedfrom light is stable over a 28 day period J Oncol Pharm Practice 2007; 13: 33-37.
03/09/2007 Hitchingham L, Thomas VH. Development of a semi-automated chemical stability system to analyse solution based formulations in support of discovery candidate selection. This paper describes the semi-automated chemical stability system (SACSS) set-up, method validation and use. This process has proven to be a good indicator of chemical and physical stability in greater than 90% of the compounds tested. Ref : J Pharm Biomed Anal 2007; 43: 522-526.
03/09/2007 Development and validation of a stability-indicating analytical method for the quantitation of oxytocin in pharmaceutical dosage forms J Pharm Biomed Anal 2007;43,1: 179-185.
31/08/2007 Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion The shelf life (T90%) of etoposide in lipid emulsion was estimated to be 47 days at 25°C and it would be stable when stored for 427 days at 4°C, which is a significant improvement compared with a stability of 9.5 days in aqueous solution at 25°C. J Pharm Sci 2007; 96, 7: 1719-1726.
28/08/2007 Stability of palonosetron in Y-site Physical and chemical stability of palonosetron with metoclopramide and promethazine during simulated Y-site administration. Results : Palonosetron hydrochloride is physically compatible and chemically stable with undiluted metoclopramide hydrochloride and also with promethazine hydrochloride diluted in 5% dextrose injection during simulated Y-site administration. Ref: Int J Pharm Compound 2007 ; 11, 1 : 82-85
24/08/2007 Physical compatibility and chemical stability of mycophenolate mofetil during simulated Y-site administration with commonly coadministered drugs Conclusion. Mycophenolate mofetil was physically compatible and chemically stable with vancomycin, cefepime, norepinephrine, dopamine, and tacrolimus for up to four hours of simulated Y-site administration. The physical compatibility of mycophenolate mofetil with cyclosporine could not be confirmed. Am J Health Syst Pharm 2007; 64, 13, 1410-1414.
21/08/2007 Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability. In this study, the authors have demonstrated that Tramadol HCl (100-400 mg/day) can be formulated together in saline with hyoscin N-butyl bromide (dose range 40-80 mg/day) for sc infusion using a 60 ml drug infuser for a duration of 7 days. Ref : Support Care Cancer 2007; 15: 57-62.
17/08/2007 Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated. Pharmazie 2007; 62, 5: 327-336.
14/08/2007 Xiao B, Gozo SK, Herz L. Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products. J Pharm Biomed Anal 2007; 43: 558-565. In this paper, HPLC methods were developped and validated for potential extractables from commercial elastomeric stoppers in a complex surfactant matrix.
07/08/2007 Peut-on conditionner les solutions de docétaxel dans des poches en PVC ? In this paper, the authors have demonstrated that docetaxel solutions were stable for 48 hours in PVC and poyethylene containers. However, PVC infusion bags should be avoided because the leaching of plasticizer after the injection of docetaxel. The DEHP concentration increases with time. J Pharm Clin 2006; 25, 3: 147-152.
03/08/2007 Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated. Pharmazie 2007; 62, 5: 327-336.
31/07/2007 Physical stability of 20% lipid injectable emulsions via simulated syringe infusion: Effects of glass vs plastic product packaging. J Parent and Enter Nutr 2007; 31, 2: 148-153.
27/07/2007 Stability of busulfan in polypropylene syringes Busulfan injection (Busilvex®, Busulfex) stored in B/Braun syringes at 18-20°C without light protection or refrigerated was stable for up to 28 days. Unused busulfan injection is not necessarily to be discarded but can be stored for a prolonged period of time in a rubber free syringe, preferably under refrigeration. Ref: Pharmazie 2006; 61: 845-850.
24/07/2007 Stability of ertapenem in aqueous solutions. In
this study the kinetics of ertapenem was studied in aqueous solutions
at various pH by using two HPLC methods. Ertapenem has the greatest
stability at pH 5-6. Ref : J Pharm Biomed Anal 2007; 43: 445-449.
20/07/2007 Stability of oxytocin Oxytocin was demonstrated to be physically and chemically stable when admixed in 5% dextrose injection or 0.9% sodium chloride inujection for 90 days and stored at room temperature (near 23°C). However, oxytocin in lactated Ringer’s injection should be restricted to a use period no longer than 28 days at room temperature to prevent microprecipitate formation and drug loss. Ref: Int J Pharm Compound 2006; 10, 2: 156-158.
17/07/2007 A physical and chemical stability of amphotericin B lipid complexes (Abelcet)after dilution in dextrose 5%. EJHP-Science 2007; 13, 1: 10-13.
10/07/2007 Stability of pemetrexed 25 mg/ml in a glass vial and 5 mg/ml stored in a PVC container after storage for one month at 2-8°C. EJHP-Science 2007; 13, 1: 14-16.
03/07/2007 Incompatibility of phenytoin Incompatibility: Phenytoin is incompatible with vasopressin by immediate formation of a precipitate. Ref: Am J Health Syst Pharm 2005; 62: 1969-1976.
29/06/2007 Drug compatibility with new polyolefin infusion solution containers Of the seven drugs subject to sorption to PVC, only insulin showed a substantial loss in the VISIV containers. Carmustine exhibited a loss consistent with the drug’s known chemical stability. None of the drugs that are known to leach plastic components, such as DEHP plasticizer, from PVC equipment exhibited any leached components in the VISIV containers. Ref: Am J Health Syst Pharm 2006; 63: 2379-2382.
22/06/2007 Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%® and Dianeal PD1 3·86%®) The mean moxifloxacin concentration in the Dianeal PD1 1·36% solution remained ≥90% of the initial concentration for 14 days at 4 °C, 7 days at 25 °C and 3 days at 37 °C. For Dianeal PD1 3·86%® moxifloxacin concentrations remained ≥90% for 14 days at 4 °C, 3 days at 25 °C and 12 h at 37 °C. Ref: J Clin Pharm Ther 2006; 31: 641-643.
15/06/2007 Stability of vancomycine Vancomycine hydrochloride in 5% dextrose polyolefin bags may be frozen and thawed in a microwave oven without major changes that affect concentration. Subsequent storage of the bags at 4°C is possible for at least 56 days. Within those limits, vancomycin can be prepared in advance by a centralized service, frozen, thawed and stored under refrigeration for a few days before use in hospital wards Ref: EJHP-S 2005; 11, 5: 111-113.
12/06/2007 Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration Conclusion. Palonosetron hydrochloride was physically and chemically stable with fentanyl citrate, hydromorphone hydrochloride, meperidine hydrochloride, morphine sulfate, and sufentanil citrate during simulated Y-site administration. Am J Health Syst Pharm 2007; 64,11: 1209-1213.
08/06/2007 Stability of mitomycine C for intraperitoneal administration Poster présented at Synprefh Congress in France may 2006 Can be downloaded : see in "Publications" >> "Stability and compatibility"
05/06/2007 Stability of phenylephrine hydrochloride injection in polypropylene syringes Conclusion. Phenylephrine hydrochloride diluted to a concentration of 100 µg/mL in 0.9% sodium chloride injection was stable for at least 30 days when stored in polypropylene syringes at –20 °C, 3–5 °C, and 23–25 °C. Am J Health Syst Pharm 2007; 64, 10: 1092-1095.
01/06/2007 Stabilis 3 a european database on the stability and compatibiity of injectable drugs. In EJHP 2006, 6: 77-78.
29/05/2007 Ketamine incompatibility Physical incompatibilities were observed between ketamine and acyclovir, ampicilline, sodium bicarbonate, furosemide, heparin, insulin, meropenem, phenytoin, potassium phosphate, trimethoprim/sulfametoxazole. Ref: Pharmactuel 2006; 39, 2: 71-75.
25/05/2007 Stability of dolasetron Dolasetron mesylate solutions (Anzemet®)) 20 mg/ml in syringes are stable for up to eight months at room temperature Ref: Am J Health Syst Pharm 2005; 62: 896-899.
22/05/2007 Long-term physical and chemical stability of a generic paclitaxel infusion The stability of paclitaxel was limited by physical stability and this was dependent on paclitaxel concentration in the infusion, diluent used and the storage temperature. Ref: EJHP-S 2006; 12, 6: 129-134.
19/05/2007 Send your posters to the INFOSTAB website ! You have recently presented a poster on stability or compatibility of injectable drugs during a congress. You can now present your research to the hospital pharmaceutical community by publishing your poster in the Infostab website (in "Publications" and "Stability and compatibility"). Send your poster in pdf format to the following address: infostab@wanadoo.fr
18/05/2007 Stability of ondansetron + methylprednisolone + clorazepate dipotassium diluted in dextrose 5% : you can download the poster which has be presented at the Hopipharm Congress in France in mai 2006. (poster in french).
See in the menu : "Publications" and "Stabilité and compatibilité"
15/05/2007 Stability of vancomycin in syringes The vancomycin (5 mg/ml) was found to be chemically and microbiologically stable at 4°C for 6 months. Losses were important after 14 days at 25°C.The samples subjected to simulated ward conditions were stable for 48 hours at 25°C. Ref EJHP-S 2006; 12, 6: 135-139.
12/05/2007 Dose banding - Cytotoxic drug standardization : establish the positive list of anticancer drugs to be standardized taking into account pharmacokinetic and stability studies. Workshop at the Gerpac Congress in Belgium (Sunparks Kempense Meren - Mol) October 3-5 2007. First announcement and registration form can be downloaded on the Gerpac webste : http://www.gerpac.org
11/05/2007 Stability of voriconazole Voriconazole injection 2mg/ml, when protected from light, was stable for eight days when stored at 4 or 25°C in 0.9% sodium chloride injection, six days at 4°C in 5% dextrose injection, and four days at 25°C in 5% dextrose injection. Ref: Am J Health Syst pharm 2006; 63: 1426-1426.
08/05/2007 A new interesting link has been created towards the " Association of Pharmaceutical Scientists – Stability focus group" See in "Links" and "Others links"
04/05/2007 World Health Organization (WHO) Stability testing of active substances and pharmaceutical products. This draft guideline can be downloaded on the website of the American Association of Pharmaceutical Scientists (Stability focus group). http://www.aapspharmaceutica.com/inside/focus_groups/Stability/index.asp#top
01/05/2007 The poster "Assessment of injectable drug
administration in two intensive care units and determination of
potential physico-chemical incompatibilities" presented during the EAHP Congress in Geneva (march 2006) can be freely downloaded. See in "Publications" and "Stability and compatibility".
27/04/2007 A new link has been added to present : "Stability-Indicating HPLC Methods for Drug Analysis" from L.A TRISSEL. See in "Link" and "Guidelines"
24/04/2007 "Asean Guideline on stability study of drug products" has been added in the "Guidelines list". See in "Links" and "Guidelines"
20/04/2007 Stability of vancomycin in icodextrin peritoneal dialysis solution. Premixed vancomycin-icodextrin PD solution, whether stored refrigerated or at room temperature, were found to be stable for up to 7 days. Solutions stored at body temperature were stable for up to 24 hours, permitting the practice of prewarming solutions prior to administration. Ref: Ann Pharmacother 2006; 40, 11: 1950-1954.
17/04/2007 Effect of tubing on loss of clonazépam administered by continuous subcutaneous infusion. Significant loss of clonazépam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used. Ref: J Pain Sympt Manage 2006; 31, 6: 563-567.
13/04/2007 Stability of ketamine and remifentanil : you can download the poster that has be presented at the EAHP Congress in Geneva in 2006. See in the menu : "Publications" and "Stability and compatibility"
10/04/2007 Stability and compatibility of a meperidine-clonidine mixture. A mixture of meperidine hydrochloride and clonidine remains stable in a PVC-containing reservoir, at room temperature and unprotected from daylight for at least 21 days. Ref: J Pain Symptom Manag 2006; 32, 4: 297-299.
06/04/2007 Study of the compatibility of cefotaxime with tinidazole in glucose injection. In this study, the admixture cefotaxime and tinidazole was stable for 8 hours in dextrose 5%. J Pharm Biomed Anal 2007; 43: 1849-1853.
05/04/2007 The Infostab website is now translated into 21 languages (italian has been added, translation performed by Camillo Cettuzzi)
03/04/2007 Incompatibility irinotécan/epirubicin A chemical interaction was observed using a spectrophotometric method in the spectra of irinotecan and epirubicin. The chemical interaction occured immediately after admixing and no visual or spectral changes was noticed for 24 hours after the intercation had occured. No sign of physical incompatibility was observed upon visual examination by means of effervescence, pH change, precipitation and colour change. Ref: Cancer Chemother Pharmacol 2005; 56: 529-534.
30/03/2007 Stability of paracetamol-phloroglucinol admixture. Paracetamol and phloroglucinol, prepared by adding phloroglucinol to a glass bottle of paracetamol ready to-use solution, were stable and compatible for up to 48 hours at room temperature without any protection against light. Ref: EJHP-S 2006; 12, 5: 91-95.
30/03/2007 Stability of total nutrient admixtures with lipid injectable emulsions in glass versus plastic packaging. In this paper, the physical stability of two emulsions compounded as part of a total nutrient admixture (TNA) was studied in lipids packaged in either glass or plastic containers. Am j Health Syst Pharm 2007; 64, 4: 396-403. Retour � la liste
28/03/2007 The Infostab website is now translated into 20
languages (turkish has been added, translation
performed by Aygin Bayraktar)
27/03/2007 Stability of palonosetron Palonosetron HCl (Aloxi®) is physically and chemically stable with doxorubicin HCl and epirubicin HCl during simulated Y-site administration of these drugs over 4 hours at ambient room temperature. Ref: Ann Pharmacother 2005; 39: 280-283.
23/03/2007 Stability of tazocilline Tazocin® (piperacillin/tazobactam) was found to be stable in 0.9% sodium chloride in PVC bags for up to 5 days at 7°C and 4 days at room temperature in the light. In non-PVC bags, it was stable for 17 and 3 days respectively. Ref: J Pharm Biomed Anal 2005; 39: 339-343.
20/03/2007 Stability of tramadol and haloperidol The mixture tramadol and haloperidol lactate diluted in NaCl 0.9% in polypropylene syringes is stable for 15 days at room temperature protected from light and in the refrigarator. Ref: J Pain Symptom Manag 2005; 30: 193-199.
13/03/2007 Stability of dexrazoxane : you can download the poster that will be presented at the EAHP Congress in Bordeaux (France) 21,22,23 march. See in the menu : "Publications" and "Stabilité and compatibilité"
09/03/2007 Stability of palonosetron admixtures Palonosetron hydrochloride was physically and chemically compatible with cyclophosphamide and with ifosfamide during simulated Y-site administration. Ref: Am J Health Syst Pharm 2005; 62: 1998-2000.
02/03/2007 Stability of ondansétron and methylprednisolone Ondansetron 0.16 mg/ml and methylprednisolone 2.4 mg/ml mixed in 50 ml multilayer polyolefin bags (Macoflex N®) were stable in both 5% dextrose injection and 0.9% sodium chloride injection for up to 24 hours at 20-25°C and up to 48 hours at 4-8°C. Ref: Am J Health Syst Pharm 2005; 62, 1: 2001-2005.
02/03/2007 The Infostab website is now translated into 19 languages (slovenian and croatian have been added, translation performed by Silva Pecar Cad and Karin Kasesnik (SLO) and Danijela jonjic (HR))
27/02/2007 Stability of ketorolac tromethamine Ketorolac tromethamine in dextrose 5% 100 ml polyolefin infusion bags may be frozen for 3 months and microwave thawed, without major changes that affect concentration. Ketorolac tromethamine solution may subsequently be stored at 4°C for up to 60 days. Ann Pharmacother 2005; 39: 1654-1658.
23/02/2007 The Infostab website is now translated into 17 languages (russian has beenadded, translation performed by Violeta Kontrimaviciute)
20/02/2007 Stability of dexamethasone and ketamine The mixtures of dexamethasone sodium phosphate (1 mg/14 ml) with ketamine hydrochloride (50 mg/14ml) in 0.9% sodium chloride were physically and chemically stable when stored in plastic syringes at 4°C, 23°C and 37°C and exposed to normal fluorescent light for 8 days. Ref: J Pain Symptom Manage 2005; 30: 80-86.
16/02/2007 The Infostab website is now translated into 16 languages (lithuanian has been added, translation performed by Violeta Kontrimaviciute)
13/02/2007 Palonosetron stability Palonosetron hydrochloride 25µg/ml (Aloxi®) is physically and chemically stable with lorazepam 0.25 mg/ml and midazolam HCl 1 mg/ml in dextrose 5% during simulated Y-site injection. Ref: Int J Pharm Compound 2005; 9, 3: 235-237.
09/02/2007 The Infostab website is now translated into 15 languages (hungarian has been , translation performed by Lívia Sáfrán)
06/02/2007 Stabilnost vorikonazola The solution of voriconazole 4 mg/ml diluted in dextrose 5% in PVC bags is stable for at least 15 days at 4°C. Ref: EJHP-S 2006; 12, 3: 57-59.
02/02/2007 Stability of frozen ceftriaxone Ceftriaxone in 5% dextrose 100 ml polyolefin infusion bags may be frozen and microwave thawed by two different procedures at 270 Watts and 800 Watts power without major changes affecting concentration. Storage at 2°C to 8°C of solution did not affect the stability of the solution for at least 44 days for the 270 Watts cycle and 56 days for the 800 Watts cycle. Ref: EJHP-S 2006; 13, 3: 52-56.
30/01/2007 A new link has been added in the databases towards "Syringe driver"
26/01/2007 Stability of morphine/hyoscine admixture used in palliative care. The admixture morphine hydrochloride (1.37 mg/ml >> 10 mg/ml) with hyscine-Nbutyl bromide diluted with 0.9% sodium chloride is stable for 15 days in polypropylene syringes at room temperature or at 4°C and protected from light. Ref: Support Care Cancer 2005; 13, 4: 239-245.
23/01/2007 Stability of prostaglandin E1 in aqueous solutions. The stability of prostaglandin E1 in physiological serum (NaCl) was assessed considering different factors. Results showed that PGE1 was stable during three months, pH=7, whenstored at 4°C. Ref: EJHP-S 2005; 11, 2: 31-36.
19/01/2007 Stability of doxorubicine and vincristine (VAD regimen) The mixture doxorubicine 1.4 mg/ml with vincristine 0.053 mg/ml is stable in 0.9 sodium chloride or 0.45 sodium chloride/2.5% dextrose for at least 7 days when stored at 8°C. A new, sensitive LC-MS technique in combinaison with UV/fluorescence confirmed these results. Ref: EJHP-S 2006; 1: 10-12.
16/01/2007 Compatibility irinotecan/ leucovorin Rapid degradation of irinotecan was observed in one mixture: irinotecan 0,30mg/ml and leucovorin 3.6 mg/ml. The concentrations of irinotecan were 91.5% after 30 minutes and 76.3% after 24 hours. It was concluded that irinotecan and leucovorin were physically compatible and chemically stable only for a sufficient period of time to allow concurrent infusion via a Y-site. Ref: Can J Hosp Pharm 2005; 58, 4: 212-222.
09/01/2007 Incompatibility of mycafungin Micafungin injection 1.5 mg/ml in 0.9% sodium chloride injection is physically incompatible for 4 hours after simulated Y-site co-administration at room temperature with albumin human, amiodarone, cisatracurium, diltiazem, dobutamine, epinephrine, insulin human regular, labetalol, meperidine, midazolam, morphine sulphate, mycophenolate mofetil, nesiritide, nicardipine, octreotide, ondansetron, phenytoin sodium, rocuronium bromide, vecuronium bromide. Ref : Int J Pharm compound 2006; 10, 3: 230-232.
05/01/2007 Stability of palonosetron/dacarbazine admixture Palonosetron HCl is physically and chemically stable when mixed with dacarbazine during simulated Y-site administration. However palonosetron HCl and methyl prednisolone sodium sucinate are physically incompatible, their admixture resulting in precipitation of methylprednisolone. Ref : Int J Pharm Compound 2006; 10, 3: 234-236.
02/01/2007 Stability of frozen pemetrexed Pemetrexed is chemically stable for 90 days frozen at -20°C, substantial numbers of microparticulates formes in pemetrexed diluted in the infusion dsolutions in PVC bags upon long-term frozen storage. The avoidance of freezing pemetrexed solutions in PVC bag sis therefore warranted. Ref : Ann Pharmacother 2006 ; 40, 7 : 1289-1292.
29/12/2006 Stability of pemetrexed Pemetrexed 2, 10 and 20 mg/ml is chemically stable for 2 days at room temperature and 31 days refrigerated in dextrose 5% injection and NaCl 0.9% injection. However, substantial numbers of microparticulates may form in pemetrexed diluted in the infusion solutions in PVC bags, especially during longer periods of refrigerated storage. Ref : Ann Pharmacother 2006 ; 40, 6 : 1082-1085.
26/12/2006 Incompatibility furosemide - phenylephrine The solutions of furosemide 4 mg/ml diluted in 5% glucose 5% or 0.9% sodium chloride are incompatible with the solutions of 0.64 mg/ml phenylephrine and 0.4 UI/ml vasopressine. This information is in contradiction with those of Trissel. Ref : Am J Health Syst Pharm 2006 ; 63 : 906-908.
22/12/2006 The website is now translated into 14 languages (Latvian has been included) !
19/12/2006 A new link has been added in the databases towards "Trissel's Calcium & Phosphate Compatibility in Parenteral Nutrition"
14/12/2006
Stability of kétorolac trométhamine
Ketorolac tromethamine (Taradyl®) in 5% dextrose infusion may be prepared, frozen in advance by a centralised intravenous admixture service then thawed before use, and the microwave power used for thawing in this study has no impact on the final long-term stability at 4°C at the two concentration (0.1 and 0.3 mg/ml) after 35 days.