Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, boolean given in D:\www\infostab\kinc\inc\db.php on line 152
22/07/2008
Chemical Stability of an Admixture Combining Ziconotide and Bupivacaine During Simulated Intrathecal Administration
David Shields, Rick Montenegro, Jennifer Aclan
Neuromodulation 2007 ; 10 : 1-5.



18/07/2008
Paul M, Lahlou A, Carvalho M, Blanchet B, Astier A.
Thermal stability of two monoclonal antibodies : cetuximab and bevacizumab.
EJOP 2008 ; 2, 1 : 37.



15/07/2008
Formulation and thermal sterile stability of a less painful intravenous clarithromycin emulsion containing vitamin E
Pages 47-56
Yan Lu, YanJiao Wang and Xing Tang
Int J Pharm 2008; 546+, 1-2: 47-56.



11/07/2008
Anti-Xa Stability of Diluted Dalteparin for Pediatric Use
Neil A Goldenberg, Linda Jacobson, Hannah Hathaway, Mark Tripputi, Judy Primeaux, Jason Child
Ann of Pharmacother2008, 42, 4: 511-515



08/07/2008
Stability of cefuroxime in BSS solution.
This new poster was presented at the XII Congress of the French Sociiety of Clinical Pharmacists in February 2008 (Saint malo - France)
The poster can be downloaded. See in "Publication" and "Stability and compatibility"
With the authorization of the authors.


04/07/2008
Identification and quantification of degradations in the Asp–Asp motifs of a recombinant monoclonal antibody
Gang Xiao , and Pavel V. Bondarenko
Journal of Pharmaceutical and Biomedical Analysis
Volume 47, Issue 1, 12 May 2008, Pages 23-30




01/07/2008
Improving the stability of potassium clavulanate in admixture with amoxicillin
By Elena M. Vega, BSc, PhD, Ruben H. Manzo, BSc, PhD and Nancy Sola, BSc, PhD
Hospital Pharmacist   2008;15:183-185



27/06/2008
Silicate release from glass for pharmaceutical preparations
Denise Bohre , Fabiana Bortoluzzi, Paulo Cícero Nascimento, Leandro Machado Carvalhoa and Adrian Gustavo Ramirez
International Journal of Pharmaceutics 2008, 355, 1-2 : 174-183.





24/06/2008
Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders
Jichao Kang, Oliver Lambert , Michael Ausborn and Steven P. Schwendeman
International Journal of Pharmaceutics 2008, 357, 1-2: 235-243.



20/06/2008
Stability of metoprolol tartrate injection 1 mg/mL undiluted and 0.5 mg/mL in 0.9% sodium chloride injection and 5% dextrose injection
Michael D. Kraft, Cary E. Johnson, Christopher Chung and Frank Julian
American Journal of Health-System Pharmacy, Vol. 65, Issue 7, 636-638 2008



17/06/2008
Stability of Levalbuterol in a Mixture of Levalbuterol and Ipratropium Nebulizer Solution
Weeranuj Yamreudeewong, M. Glaucia Teixeira, and Gabriele E. Mayer
Hosp Pharm 2008; 43: 303-306.



13/06/2008
Physicochemical Stability of Parenteral Nutrition Supplied as All-in-One for Neonates
Maria Skouroliakou, Chrysoula Matthaiou, Antonia Chiou, Demosthenes Panagiotakos, Antonis Gounaris, Tony Nunn and Nikolaos Andrikopoulos.
Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 2, 2008 201-209




10/06/2008
Two news poster on the stability of cytotoxic drugs can be downloaded . See in "Publications" and "Stability and compatibility"


06/06/2008
Trusley C, Ben M, Kupiec TC, Trissel LA.
Compatibility and stability of palonosetron hydrochloride with four neuromuscular blocking agents during simulated Y-site administration.
Int J Pharm Compound 2008; 12, 2: 156-160.



03/06/2008
Kupiec T, Ben M, Trusley C, Trissel LA.
Compartibility and stability of palonosetron hydrochloride with gentamicin, metronidazole, or vancomycin during simulated Y-sirte administration.
Int J Pharm Compound 2008; 12,2: 170-173.



30/05/2008
Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization
Jiaher Tian , Valentino J. Stella.
J Pharm Sci 2008; 97, 3: 1224-1235.



27/05/2008
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection
Raf De Jongh1, Ria Hens1, Violetta Basma2, Johan W. Mouton3, Paul M. Tulkens2,* and Stéphane Carryn2
J Antimicrob Chemother 2008 ; 61, 2 : 382-388.



23/05/2008
Gupta V.D.
Chemical stability of tramadol hydrochloride injection.
Int J Pharm Compound 2008; 12, 2: 161-162.



20/05/2008
Stability of TPN: influence of electrolytes
You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Stabilité des TPN: influence des électrolytes »
http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm



16/05/2008
Stability of Bortezomib Reconstituted with 0.9% Sodium Chloride at 4°C and Room Temperature (23°C)
Scott E Walker, Debbie Milliken, and Shirley Law
Can J hosp Pharm 2008; 61, 1



13/05/2008
Chemical stability of haloperidol injection by high performance thin-layer chromatography
Sigrid Mennickent, Loreto Pino , Mario Vega , Marta de Diego
J  Sep Sci 2008 ; 31, 1 : 201-206.


09/05/2008
Risks associated to injectable drugs
You can download the pdf file of this docuent (in english) on the website of the Unicersity Hospital of Lausanne (Switzerland) (after the opening, click on « Risques liés aux médicaments injectables »
http://www.chuv.ch/pha/pha_home/pha_enseignement/pha_ens_seminaires.htm



06/05/2008
Total parenteral nutrition – problems in compatibility and stability
Allan Mikael Schroder
EJHP Practice 2008; 14, 1: 65-67.




02/05/2008
Visual compatibility of caspofungin acetate with commonly used drugs during simulated Y-site delivery
Chad K. Condie, Linda S. Tyler, Brian Barker and David M. Canann
American Journal of Health-System Pharmacy, Vol. 65, Issue 5, 454-457



29/04/2008
Extended stability of iobenguane under simulated clinical conditions
George H. Hinkle, Jillian V. Dura, Richard S. Morosco and Milap C. Nahata
American Journal of Health-System Pharmacy, Vol. 65, Issue 2, 142-144



25/04/2008
Study of protein conformational stability and integrity using calorimetry and FT-Raman spectroscopy correlated with enzymatic activity
A.A. Elkordy , a,  , R.T. Forbesa and B.W. Barrya
Eur J Pharm Sci 2008; 33, 2: 177-190.





22/04/2008
Calcium and phosphate compatibility: Revisited again
David W. Newton and David F. Driscoll
Am J Health Syst Pharm 2008 65: 73-80.



18/04/2008
Strategy for identification of leachables in packaged pharmaceutical liquid formulations
Changkang Pan, Ferris Harmo, Karen Toscano, Frances Liu and Richard Vivilecchia
J Pharm Biomed Anal 2008; 46, 3: 520-527.



15/04/2008
A new poster can be freely downloaded. See "Publications" and "Stability and compatibility"
Comparative of different intravenous infusion containers.
This poster was presented at the 10th Congress of the European Association of Hospital Pharmacists. Lison, Portugal, 16-18 March 2005.



11/04/2008
Hong Yao Zhanga, Xing Tang , a,  , Hong Ying Lia and Xiao Liang Liua
A lipid microsphere vehicle for vinorelbine: Stability, safety and pharmacokinetics
International Journal of Pharmaceutics 2008;348 ,1-2: 70-79



08/04/2008
Adwoa O. Nornooa, Diana S.-L. Chowb
Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
International Journal of Pharmaceutics 208; 349, Issues 1-2, 117-123





04/04/2008
Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis
Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids
Journal of Separation Science 2006 ; 29, 11 : 1550-1560.



01/04/2008
Tiffany Derrick, Adeola O. Grillo, Samadhi N. Vitharana, LaToya Jones, Jason Rexroad, Ambarish Shah, Melissa Perkins, Thomas M. Spitznagel, C. Russell Middaugh.
Effect of polyanions on the structure and stability of repiferminTM (keratinocyte growth factor-2)
J Pharm Sci 2007; 96, 4: 761-776.


28/03/2008
Frederic Adnet, Laurence Le Moyec, Charles E Smith, Michel Galinski, Patricia Jabre1, Frederic Lapostolle
Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy
Emergency Medicine Journal 2007;24:168-169



25/03/2008
Kupiec Thomas C, Skinner Rodney, Lanier Lance
Quality-Control Analytical Methods: Stability Versus Potency Testing: The Madness is in the Method
Int J Pharm Compound 2008 ; 12, 1 : 50-53



21/03/2008
Stability of Injectable Oxytocics in Tropical Climates: Results of Field Surveys and Simulation Studies on Ergometrine, Methylergometrine and Oxytocin - EDM Research Series N° 08
On WHO website


18/03/2008
Roberto Sacco, Giovanna Sacchetto, Mirella Francalanci, Cinzia Boselli
Studio di stabilità chimico-fisica di una formulazione per la terapia antalgica a base di levobupivacaina e fentanyl
Bolletino SIFO 2-2006



11/03/2008

Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T, Forest Jean-Marc, Hildgen Patrice
Room Temperature Stability of Injectable Succinylcholine Dichloride
Int J Pharm Compound 2008 ; 12, 1 : 83-85.



07/03/2008
Cristiana Romanazzi, Stella Sferra, Anna Campi, Barbara Rabino, Marco Barbieri, Sofia Castellani, Luana Sabbatini, Paola Scanavacca
Dexrazoxane: stabilità in soluzione
Bolletino SIFO 2007;53 ,4 : 178-180




04/03/2008
Development of a validated HPLC method for the determination of four penicillin antibiotics in pharmaceuticals and human biological fluids
Victoria F. Samanidou , Evaggelia N. Evaggelopoulou, Ioannis N. Papadoyannis
Journal of Separation Science 2006 ; 29, 11 : 1550-1560.



29/02/2008
Stabilis online !
Click on "Stabilis" on the left side on the screen and then click on the button "Stabilis"
By choosing "List of drugs", you have access to 374 monographs of injectable drugs with informations on stability in solutions, in admixtures, incompatibilities ...

29/02/2008
Stability of a mixture of technetium Tc 99m sulfur colloid and lidocaine hydrochloride
Jillian V. Dura and George H. Hinkle
Am J Health Syst Pharm 2007; 64, 23: 2477-2479.



26/02/2008
A Comparison of Plasticizers for Use in Flexible Vinyl Medical Products
Data from three studies suggest that using trimellitates can reduce the amount of plasticizer that may migrate from PVC devices.
Richard C. Adams
Medical Device Link dec 2007



22/02/2008
Diethylhexylphthalate Extracted by Typical Newborn Lipid Emulsions From Polyvinylchloride Infusion Systems Causes Significant Changes in Histology of Rabbit Liver
P. D. Steffan Loff, Ulrike Subotic, Jasmina Oulmi-Kagermann, Bettina Kränzlin, Maria-Franziska Reinecke and Christiane Staude
Journal of Parenteral and Enteral Nutrition, Vol. 31, No. 3, 2007 188-193



19/02/2008
New links to articles or posters have been placed into the list "Stability and compatibility". See "Publications" and "Stability and compatibility".


12/02/2008
Chemical stability of midazolam injection by high performance liquid chromatography
Marta de Diego, Gloria Godoy,Sigrid Mennickent
Journal of Separation Science 2007 ; 30, 12 : 1833-1838.



11/02/2008
STABILIS online !
The database STABILIS is now available on the website. You have to choose "Stabilis" on the menu at the left side of the screen.
The database contains important improvements like a general search function, a search function for incompatibilities, possibility to create a pdf file for each monograph etc.
Don't hesitate  to give your opinion about the new Stabilis database by using the email adress : infostab@wanadoo.fr


29/01/2008
An alternative to DEHP plasticized polyvinyl chloride in chemotherapy drug delivery systems
Len Czuba, Harry Puryear, Kamal Sarkar.
Journal of Vinyl and Additive Technology 2004 ; 2, 4 : 314-320.



25/01/2008
Dual effects on Tween 80 on protein stability
Wang W, Wang Y.J, D.Q. Wang D.Q.
Int J Pharm 2008 ; 347, 1-2 : 31-38.



22/01/2008
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Int J Pharm Compound 2007; 11, 6: 520-524.



18/01/2008
Tracking of the Kinetic Stability of 2 Types of Total Nutrient Admixtures Containing Different Lipid Emulsions
Judit Balogh, Dorottya Kiss, Judit Dredán, István Puskás, Ferenc Csempesz, and Romána Zelkó
AAPS PharmSci. 2006; 7(4)



15/01/2008
A rapid technique to evaluate the oxidative stability of a model drug.
Felton LA, Yang J, Shah K, Omidian H, Rocca JG
Drug Dev Ind Pharm 2007 Jun; 33(6):683-9.



15/01/2008
Stability of 70% alcohol solutions in polypropylene syringes for use in ethanol-lock therapy
Mary Petrea Cober and Cary E. Johnson
Am J Health Syst Pharm 2007; 64, 23: 2480-2482.



11/01/2008
Evaluation of the chemical compatibility of plastic contact materials and pharmaceutical products; safety considerations related to extractables and leachables
Dennis Jenke *
J Pharm Sci 2007; 96, 10: 2566-2581.



08/01/2008
Stability of vecuronium in sterile water for injection stored in polypropylene syringes for 21 days
Cary E. Johnson and Mary Petrea Cober
Am J Health Syst Pharm 2007; 64, 22: 2356-2358.




04/01/2008
de Diego M, Godoy G, Mennickent S
Chemical stability of midazolam injection by high performance liquid chromatography.
J Sep Sci 2007 Jun 12.



01/01/2008
Compatibility and stability of tramadol and dexamethasone in solution and its use in terminally ill patients
S. Negro, A. Salam, Y. Sánchez, M. L. Azuara, E. Barcia.
J Clin Pharm Ther 2007; 32, 5: 441-444.




28/12/2007
Amélioration des pratiques d’administration des antibiotiques injectables : proposition et évaluation d’un guide de compatibilité physico-chimique (in french)
A Camut, V Noirez, B Gustin, A Khalife
J Pharm Clin 2007; 26, 3: 143-150.





25/12/2007
Accelerated aging: Prediction of chemical stability of pharmaceuticals
Kenneth C. Waterman ,  and Roger C. Adami
Int J Pharm 2005; 293, 1-2: 101-125.



21/12/2007
A Four-Column Approach to Developing Stability-Indicating HPLC Methods
This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients.
LCGC North America, Jun 1, 2002



18/12/2007
Liposomal amphotericin B eye drops to treat fungal keratitis: Physico-chemical and formulation stability
K. Morand, A.C. Bartoletti, A. Bochot, G. Barratt, M.L. Brandely and F. Chast
Int J Pharm 2007; 334, 1-2: 150-153.



14/12/2007
Influence du stress  mécamique sur la stabilité du bévacizumab. (in french)
Lahlou, Blanchet B, Carvalho M, Astier A, Paul M.
Presented at the SFPO Congress in Nice (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.



11/12/2007
Liposome formulation of Paclitaxel with enhanced solubility and stability.
Yang T, Cui FD, Choi MK, Lin H, Chung SJ, Shim CK, Kim DD
Drug Deliv 2007 Jun; 14(5):301-8.


07/12/2007
Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion.
Tian L, He H, Tang X
J Pharm Sci 2007 May 14.



04/12/2007
Stabilité thermique de 2 anticorps monoclonaux : bevacizumab et cetuximab. (in french)
Paul M, Lahlou A, Carvahlo M, Blanchet B, Astier A.
Presented at the SFPO Congress in Nice (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.


30/11/2007
Stability of Docetaxel Solution after Dilution in Ethanol and Storage in Vials and after Dilution in Normal Saline and Storage in Bags.
Scott E Walker, Flay Charbonneau, and Shirley Law
Can J Hosp Pharm 2007; 60, 5: 217-284.


27/11/2007
Are monoclonal antibody stable ? (in french)
Pr Alain ASTIER
Presented at the  SFPO Congress in Nice  (october 2007)
Can be downloaded. See "Publications" and "Stability and compatibility"
With the authorization of the author.


23/11/2007
A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate 'dose-banding'.
Kaestner S, Sewell G.
In this study, the authors have demonstrated that carboplatine infusions could be stored refrigerated for 84 days.
J Oncol Pharm Practice 2007; 13: 119-126.


20/11/2007
Examination of stability and compatibility of flucloxacillin (Floxapen®) and ceftazidime (Fortum®) in two infusion media: relevance for the clinical praxis.
Florian Thalhammer, Alexandra Maier-Salamon und Walter Jäger.
Wien Med Wochenschr 2005 ; 155 (13-14) : 337-343.


16/11/2007
Compatibility of insulin over 24 hours in standard and bicarbonate-based peritoneal dialysis solutions contained in bags made of different materials.
Voges M, Divino-Filho JC, Faict D, Somers F, Vermeulen P.
Perit Dial Int 2006 Jul-Aug; 26(4) :498-502.


13/11/2007
Pathological Consequences From the Infusion of Unstable Lipid Emulsion Admixtures in Guinea Pigs.
Todd Canada.
Nutrition in Clinical Practice 2006; 21, 6: 636-637.


09/11/2007
Stability and compatibility of histamine H2-receptor antagonists in parenteral nutrition mixtures.
Puzovic M, Hardy G.
Curr Opin Clin Nutr Metab Care 2007 May; 10(3) :311-7.


09/11/2007
Physicochemical stability of lipid injectable emulsions: Correlating changes in large globule distributions with phase separation behavior.
Thomas Gonyon, Pankaj Patel, Heather Owen, Andrew J. Dunham and Phillip W. Carter.
Int J Pharm 2007; 343, 1-2: 208-219.


06/11/2007
Estabilidad de parecoxib en dilución con otros fármacos y administrado en perfusión continua IV para el control del dolor postoperatorio.
Acín Lázaro MP, Bono Ariño C, Martínez Bazán R, Manzanares Marín I, Faci Bouthelier A,
Velamazán Blocona MJ, Facorro Gaspar E, Sanz Gandasegui M, Aleploglian Barbarian K
Investig. Clin. Farm. 2005, Vol. 2 (4): 195-203


02/11/2007
Stability of oxaliplatin in infusion bags containing 5% dextrose injection.
Pascal André, Salvatore Cisternino, Anne-Lise Roy, Fouad Chiadmi, Joël Schlatter, Pascal Agranat, Olivier Fain and Jean-Eudes Fontan
Conclusion. Oxaliplatin 0.7 mg/mL in infusion bags containing 5% dextrose injection was chemically stable for at least 30 days at both 3–7 °C and 20–24 °C without regard to light exposure.
Am J Health-Syst Pharm,2007;64,18/1950-1954


30/10/2007
Use of microcalorimetry and its correlation with size exclusion chromatography for rapid screening of the physical stability of large pharmaceutical proteins in solution.
Burton L, Gandhi R, Duke G, Paborji M
Pharm Dev Technol 2007; 12(3) :265-73.


26/10/2007
Validation of an HPLC method for the analysis of decomposition products in injectable diazepam.
Hudecová T, Bátorová V, Hatrík S, Havránek E
Ceska Slov Farm 2004 Sep; 53(5) :228-33.


23/10/2007
Compatibility and stability of furosemide and dexamethasone combined in infusion solutions.
Negro S, Rendon AL, Azuara ML, Sánchez Y, Fernández-Carballido A, Barcia E
These results confirm the stability of mixtures prepared with sodium furosemide (< or = 120 mg/day) and dexamethasone sodium phosphate (< or = 40 mg/day) for a period of 5 days and with independence of their storage at 4 degrees C or 25 degrees C.
Arzneimittelforschung 2006; 56(10) :714-20.


19/10/2007
Long-term stability of sodium folinate  in dextrose 5% polyolefin bags at 4°C.
Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
J Oncol Pharm Practice 2007; 13: 99-103.


16/10/2007
Shelf-lives of IV products — are there any limits?
By Michael Allwood, PhD, FRPharmS and Graham Sewell, PhD, MRPharmS
Hospital Pharmacist   2007;14:242



12/10/2007
Ortega Valín L, del Pozo Ruiz JJ.
Cómo y por qué estudiar la estabilidad de las mezclas de fármacos para uso intravenoso
Investig. Clin. Farm. 2006, Vol. 3 (3): 130-135


09/10/2007
Mário L de Lemos, Linda Hamata
Stability issues of parenteral chemotherapy drugs
Journal of Oncology Pharmacy Practice, Vol. 13, No. 1, 27-31 (2007)


05/10/2007
A simulation study with statistical evaluation for the determination of non-isothermal kinetics conditions in drugs stability
Eur J  Pharm Sci; 2007; 31, 5: 277-287.



02/10/2007
Stability of an extemporaneously prepared recombinant human interferon alfa-2b eye drop formulation.
Conclusion. An extemporaneously pre -pared rh-IFN- 2b eye drop formulation was stable at 5 ± 3 °C for 15 days and at 28 ± 2 °C for 7 days.
Am J Health Syst Pharm;  64, 16: 1716-1719.


28/09/2007
Incompatibility reactions in iv drug therapy : Preventable medication errors.
Presented by Pr Stefan Muhlebach, Bern, Switzerland during the EAHP congress in Bordeaux, France, march 2007.
You can download the pdf file. See in "Publications" and "Stability and compatibility"
With the authorization of the author.


25/09/2007
Incompatibility of iv drugs in daily practice : an underrecognised and underestimated problem.
by Karin Nemec, PhD from Vienna, Austria
Presented during the seminar "Incompatibility reactions in drug therapy – preventable medication errors" in the EAHP Congress in Bordeaux, France,  march 2007.
You can download the pdf file. See in "Publications" and "Stability and compatibility"
With the authorization of the author


21/09/2007
Room-temperature storage of medications labeled for refrigeration.
Conclusion. Information regarding the room-temperature storage of 79 medications labeled for refrigerated storage was compiled.
Am J Health Syst Pharm 2007; 64, 16: 1711-1715.



18/09/2007
Viability of micro-organisms in novel anticancer drug solutions.
Conclusion : Micro-organisms can survive in diluted solutions of antineoplastic drugs and proliferate when transferred to proper growth media.
EJHP-Science 2007; 13, 2: 27-32.


14/09/2007
Development and validation of a simple HPLC method for simultaneous in vitro determination of amoxicillin and metronidazole at single wavelength.
J Pharm Biomed Anal 2007; 43, 1: 325-329.



11/09/2007
Stability issues of parenteral chemotherapy drugs.
J oncol Pharm Practice 2007; 13: 27-31.


07/09/2007
Stability of a heparin-free 50% ethanol lock solution for central venous catheters.
These findings suggest that a 50% (v/v) ethanol solution stored in a syringe at room temperature, not protected from light is stable over a 28 day period
J Oncol Pharm Practice 2007; 13: 33-37.


03/09/2007
Hitchingham L, Thomas VH.
Development of a semi-automated chemical stability system to analyse solution based formulations in support of discovery candidate selection.
This paper describes the semi-automated chemical stability system (SACSS) set-up, method validation and use. This process has proven to be a good indicator of chemical and physical stability in greater than 90% of the compounds tested.
Ref : J Pharm Biomed Anal 2007; 43: 522-526.



03/09/2007
Development and validation of a stability-indicating analytical method
for the quantitation of oxytocin in pharmaceutical dosage forms
J Pharm Biomed Anal 2007;43,1: 179-185.



31/08/2007
Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion
The shelf life (T90%) of etoposide in lipid emulsion was estimated to be 47 days at 25°C and it would be stable when stored for 427 days at 4°C, which is a significant improvement compared with a stability of 9.5 days in aqueous solution at 25°C.
J Pharm Sci 2007; 96, 7: 1719-1726.



28/08/2007
Stability of palonosetron in Y-site
Physical and chemical stability of palonosetron with metoclopramide and promethazine during simulated Y-site administration.
Results : Palonosetron hydrochloride is physically compatible and chemically stable with undiluted metoclopramide hydrochloride and also with promethazine hydrochloride diluted in 5% dextrose injection during simulated Y-site administration.
Ref: Int J Pharm Compound 2007 ; 11, 1 : 82-85



24/08/2007
Physical compatibility and chemical stability of mycophenolate mofetil during simulated Y-site administration with commonly coadministered drugs
Conclusion. Mycophenolate mofetil was physically compatible and chemically stable with vancomycin, cefepime, norepinephrine, dopamine, and tacrolimus for up to four hours of simulated Y-site administration. The physical compatibility of mycophenolate mofetil with cyclosporine could not be confirmed.
Am J Health Syst Pharm 2007; 64, 13, 1410-1414.


21/08/2007
Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability.
In this study, the authors have demonstrated that Tramadol HCl (100-400 mg/day) can be formulated together in saline with hyoscin N-butyl bromide (dose range 40-80 mg/day) for sc infusion using a 60 ml drug infuser for a duration of 7 days.
Ref : Support Care Cancer 2007; 15: 57-62.



17/08/2007
Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique
Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated.
Pharmazie 2007; 62, 5: 327-336.



14/08/2007
Xiao B, Gozo SK, Herz L.
Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products.
J Pharm Biomed Anal 2007; 43: 558-565.
In this paper, HPLC methods were developped and validated for potential extractables from commercial elastomeric stoppers in a complex surfactant matrix.



07/08/2007
Peut-on conditionner les solutions de docétaxel dans des poches en PVC ?
In this paper, the authors have demonstrated that docetaxel solutions were stable for 48 hours in PVC and poyethylene containers. However, PVC infusion bags should be avoided  because the leaching of plasticizer after the injection of docetaxel. The DEHP concentration increases with time.
J Pharm Clin 2006; 25, 3: 147-152.



03/08/2007
Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique
Conclusion: The results suggest compatibility of drug pairs in their binary mixtures. However, ternary mixtures show somewhat larger interactions. The magnitude of interaction enthalpy of a ternary mixture comprising tinidazole, clarithromycin and omeprazoles which are available as a marketed kits has been calculated to be significant, suggesting that the three drugs cannot be co-formulated.
Pharmazie 2007; 62, 5: 327-336.


31/07/2007
Physical stability of 20% lipid injectable emulsions via simulated syringe infusion: Effects of glass vs plastic product packaging.
J Parent and Enter Nutr 2007; 31, 2: 148-153.


27/07/2007
Stability of busulfan in polypropylene syringes
Busulfan injection (Busilvex®, Busulfex) stored in B/Braun syringes at 18-20°C without light protection or refrigerated was stable for up to 28 days. Unused busulfan injection is not necessarily to be discarded but can be stored for a prolonged period of time in a rubber free syringe, preferably under refrigeration.
Ref: Pharmazie 2006; 61: 845-850.



24/07/2007
Stability of ertapenem in aqueous solutions.
In this study the kinetics of ertapenem was studied in aqueous solutions at various pH by using two HPLC methods. Ertapenem has the greatest stability at pH 5-6.
Ref : J Pharm Biomed Anal 2007; 43: 445-449.


20/07/2007
Stability of oxytocin
Oxytocin was demonstrated to be physically and chemically stable when admixed in 5% dextrose injection or 0.9% sodium chloride inujection for 90 days and stored at room temperature (near 23°C). However, oxytocin in lactated Ringer’s injection should be restricted to a use period no longer than 28 days at room temperature to prevent microprecipitate formation and drug loss.
Ref: Int J Pharm Compound 2006; 10, 2: 156-158.



17/07/2007
A physical and chemical stability of amphotericin B lipid complexes (Abelcet)after dilution in dextrose 5%.
EJHP-Science 2007; 13, 1: 10-13.


13/07/2007
Isolation and characterisation of degradation impurities in docetaxel drug substances and its formulation.
J pharm Biomed Anal 2007; 43: 1228-1235.



10/07/2007
Stability of pemetrexed 25 mg/ml in a glass vial and 5 mg/ml stored in a PVC container after storage for one month at 2-8°C.
EJHP-Science 2007; 13, 1: 14-16.


06/07/2007
Recent developments on long-term stability test conditions.
Singh S, Kumar V.
This article can be downloaded on the website of the American Association of Pharmaceutical Scientis
http://www.aapspharmaceutica.com/inside/focus_groups/Stability/index.asp#top



03/07/2007
Incompatibility of phenytoin
Incompatibility: Phenytoin is incompatible with vasopressin by immediate formation of a precipitate.
Ref: Am J Health Syst Pharm 2005; 62: 1969-1976.


29/06/2007
Drug compatibility with new polyolefin infusion solution containers
Of the seven drugs subject to sorption to PVC, only insulin showed a substantial loss in the VISIV containers. Carmustine exhibited a loss consistent with the drug’s known chemical stability. None of the drugs that are known to leach plastic components, such as DEHP plasticizer, from PVC equipment exhibited any leached components in the VISIV containers.
Ref: Am J Health Syst Pharm 2006; 63: 2379-2382.



26/06/2007
«Stability studies – Assessment experience » was presented at the WHO training workshop on pharmaceutical quality, GMP and bioequivalence with a focus on artemisenines. Guilin, China, 9 January 2006 by Pr JANOS POGANY.
http://mednet3.who.int/prequal/trainingresources/pq_pres/workshop_China_Jan2006/StabilityStudies.ppt



22/06/2007
Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%® and Dianeal PD1 3·86%®)
The mean moxifloxacin concentration in the Dianeal PD1 1·36% solution remained ≥90% of the initial concentration for 14 days at 4 °C, 7 days at 25 °C and 3 days at 37 °C. For Dianeal PD1 3·86%® moxifloxacin concentrations remained ≥90% for 14 days at 4 °C, 3 days at 25 °C and 12 h at 37 °C.
Ref: J Clin Pharm Ther 2006; 31: 641-643.



19/06/2007
Stability studies of drugs used in oncology : the role of the hospital pharmacist
Published in EJHP practice 2006, 6 : 75-76.



15/06/2007
Stability of vancomycine
Vancomycine hydrochloride in 5% dextrose polyolefin bags may be frozen and thawed in a microwave oven without major changes that affect concentration. Subsequent storage of the bags at 4°C is possible for at least 56 days. Within those limits, vancomycin can be prepared in advance by a centralized service, frozen, thawed and stored under refrigeration for a few days before use in hospital wards
Ref: EJHP-S 2005; 11, 5: 111-113.



12/06/2007
Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration
Conclusion. Palonosetron hydrochloride was physically and chemically stable with fentanyl citrate, hydromorphone hydrochloride, meperidine hydrochloride, morphine sulfate, and sufentanil citrate during simulated Y-site administration.
Am J Health Syst Pharm 2007; 64,11: 1209-1213.



08/06/2007
Stability of mitomycine C for intraperitoneal administration
Poster présented at Synprefh Congress in France may 2006
Can be downloaded : see in "Publications" >> "Stability and compatibility"


05/06/2007
Stability of phenylephrine hydrochloride injection in polypropylene syringes
Conclusion. Phenylephrine hydrochloride diluted to a concentration of 100 µg/mL in 0.9% sodium chloride injection was stable for at least 30 days when stored in polypropylene syringes at –20 °C, 3–5 °C, and 23–25 °C.
Am J Health Syst Pharm 2007; 64, 10: 1092-1095.


01/06/2007
Stabilis 3 a european database on the stability and compatibiity of injectable drugs.
In EJHP 2006, 6: 77-78.




29/05/2007
Ketamine incompatibility
Physical incompatibilities were observed between ketamine and acyclovir, ampicilline, sodium bicarbonate, furosemide, heparin, insulin, meropenem, phenytoin, potassium phosphate, trimethoprim/sulfametoxazole.
Ref: Pharmactuel 2006; 39, 2: 71-75.



25/05/2007
Stability of dolasetron
Dolasetron mesylate solutions (Anzemet®)) 20 mg/ml in syringes are stable for up to eight months at room temperature
Ref: Am J Health Syst Pharm 2005; 62: 896-899.


22/05/2007
Long-term physical and chemical stability of a generic paclitaxel infusion
The stability of paclitaxel was limited by physical stability and this was dependent on paclitaxel concentration in the infusion, diluent used and the storage temperature.
Ref: EJHP-S 2006; 12, 6: 129-134.



19/05/2007
Send your posters to the INFOSTAB website !
You have recently  presented a poster on stability or compatibility of injectable drugs during a congress.  You can now present your research to the hospital pharmaceutical community by publishing your poster in the Infostab website (in "Publications" and "Stability and compatibility"). Send your poster in pdf format to the following address: infostab@wanadoo.fr


18/05/2007
Stability of ondansetron + methylprednisolone + clorazepate dipotassium diluted in dextrose 5% : you can download the poster which has be presented at the Hopipharm Congress in France in mai 2006. (poster in french).

See in the menu : "Publications" and "Stabilité and compatibilité"

15/05/2007
Stability of vancomycin in syringes
The vancomycin (5 mg/ml) was found to be chemically and microbiologically stable at 4°C for 6 months. Losses were important after 14 days at 25°C.The samples subjected to simulated ward conditions were stable for 48 hours at 25°C.
Ref EJHP-S 2006; 12, 6: 135-139.



12/05/2007
Dose banding - Cytotoxic drug standardization : establish the positive list of anticancer drugs to be standardized taking into account pharmacokinetic and stability studies.
Workshop at the Gerpac Congress in Belgium (Sunparks Kempense Meren - Mol) October 3-5 2007.
First announcement and registration form can be downloaded on the Gerpac webste : http://www.gerpac.org


11/05/2007
Stability of voriconazole
Voriconazole injection 2mg/ml, when protected from light, was stable for eight days when stored at 4 or 25°C in 0.9% sodium chloride injection, six days at 4°C in 5% dextrose injection, and four days at 25°C in 5% dextrose injection.
Ref: Am J Health Syst pharm 2006; 63: 1426-1426.


08/05/2007
A new interesting link has been created towards the " Association of Pharmaceutical Scientists – Stability focus group"
See in "Links" and "Others links"



04/05/2007
World Health Organization (WHO)
Stability testing of active substances and pharmaceutical products.
This draft guideline can be downloaded on the website of the American Association of Pharmaceutical Scientists (Stability focus group).
http://www.aapspharmaceutica.com/inside/focus_groups/Stability/index.asp#top



01/05/2007
The poster "Assessment of injectable drug administration in two intensive care units and determination of potential physico-chemical incompatibilities" presented during the EAHP Congress in Geneva (march 2006) can be freely downloaded.
See in "Publications" and "Stability and compatibility".

27/04/2007
A new link has been added to present : "Stability-Indicating HPLC Methods for Drug Analysis" from L.A TRISSEL.
See in "Link" and "Guidelines"


24/04/2007
"Asean Guideline on stability study of drug products" has been added in the "Guidelines list".
See in "Links" and "Guidelines"


20/04/2007
Stability of vancomycin in icodextrin peritoneal dialysis solution.
Premixed vancomycin-icodextrin PD solution, whether stored refrigerated or at room temperature, were found to be stable for up to 7 days. Solutions stored at body temperature were stable for up to 24 hours, permitting the practice of prewarming solutions prior to administration.
Ref: Ann Pharmacother 2006; 40, 11: 1950-1954.



17/04/2007
Effect of tubing on loss of clonazépam administered by continuous subcutaneous infusion.
Significant loss of clonazépam (up to 50%) was observed in all solutions infused through PVC tubing. Solutions infused through non-PVC tubing retained greater than 90% of the initial concentration of clonazepam. It is recommended that when administering clonazepam using a syringe driver, non-PVC tubing be used.
Ref: J Pain Sympt Manage 2006; 31, 6: 563-567.



13/04/2007
Stability of ketamine and remifentanil : you can download the poster that has be presented at the EAHP Congress in Geneva in 2006.
See in the menu : "Publications" and "Stability and compatibility"

10/04/2007
Stability and compatibility of a meperidine-clonidine mixture.
A mixture of meperidine hydrochloride and clonidine remains stable in a PVC-containing reservoir, at room temperature and unprotected from daylight for at least 21 days.
Ref: J Pain Symptom Manag 2006; 32, 4: 297-299.



06/04/2007

Study of the compatibility of cefotaxime with tinidazole in glucose injection.
In this study, the admixture cefotaxime and tinidazole was stable for 8 hours in dextrose 5%.
J Pharm Biomed Anal 2007; 43: 1849-1853.

05/04/2007
The Infostab website is now translated into  21 languages (italian has been added, translation performed by Camillo Cettuzzi)

03/04/2007
Incompatibility irinotécan/epirubicin
A chemical interaction was observed using a spectrophotometric method in the spectra of irinotecan and epirubicin. The chemical interaction occured immediately after admixing  and no visual or spectral changes was noticed for 24 hours after the intercation had occured. No sign of physical incompatibility was observed upon visual examination by means of effervescence, pH change, precipitation and colour change.
Ref: Cancer Chemother Pharmacol 2005; 56: 529-534.



30/03/2007
Stability of paracetamol-phloroglucinol admixture.
Paracetamol and phloroglucinol, prepared by adding phloroglucinol to a glass bottle of paracetamol ready to-use solution, were stable and compatible for up to 48 hours at room temperature without any protection against light.
Ref: EJHP-S 2006; 12, 5: 91-95.



30/03/2007
Stability of total nutrient admixtures with lipid injectable emulsions in glass versus plastic packaging.
In this paper, the physical stability of two emulsions compounded as part of a total nutrient admixture (TNA) was studied in lipids packaged in either glass or plastic containers.
Am j Health Syst Pharm 2007; 64, 4: 396-403.
Retour � la liste


28/03/2007
The Infostab website is now translated into  20 languages (turkish has been added, translation performed by Aygin Bayraktar)

27/03/2007
Stability of palonosetron
Palonosetron HCl (Aloxi®) is physically and chemically stable with doxorubicin HCl and epirubicin HCl during simulated Y-site administration of these drugs over 4 hours at ambient room temperature.
Ref: Ann Pharmacother 2005; 39: 280-283.


23/03/2007
Stability of tazocilline
Tazocin® (piperacillin/tazobactam) was found to be stable in 0.9% sodium chloride in PVC bags for up to 5 days at 7°C and 4 days at room temperature in the light. In non-PVC bags, it was stable for 17 and 3 days respectively.
Ref: J Pharm Biomed Anal 2005; 39: 339-343.


20/03/2007
Stability of tramadol and haloperidol
The mixture tramadol and haloperidol lactate diluted in NaCl 0.9% in polypropylene syringes is stable for 15 days at room temperature  protected from light and in the refrigarator.
Ref: J Pain Symptom Manag 2005; 30: 193-199.


16/03/2007
The stability of anticancer drugs by Alain ASTIER
EJHP-P 2007, 2: 90-92.


13/03/2007
Stability of dexrazoxane : you can download the poster that will be presented at the EAHP Congress in Bordeaux (France) 21,22,23 march.
See in the menu : "Publications" and "Stabilité and compatibilité"


09/03/2007
Stability of palonosetron admixtures
Palonosetron hydrochloride was physically and chemically compatible with cyclophosphamide and with ifosfamide during simulated Y-site administration.
Ref: Am J Health Syst Pharm 2005; 62: 1998-2000.



02/03/2007
Stability of ondansétron and methylprednisolone
Ondansetron 0.16  mg/ml and methylprednisolone 2.4 mg/ml mixed in 50 ml multilayer polyolefin bags (Macoflex N®) were stable in both 5% dextrose injection and 0.9% sodium  chloride injection for up to 24 hours at 20-25°C and up to 48 hours at 4-8°C.
Ref: Am J Health Syst Pharm 2005; 62, 1: 2001-2005.



02/03/2007
The Infostab website is now translated into  19 languages (slovenian and croatian have been added, translation performed by Silva Pecar Cad and Karin Kasesnik (SLO) and Danijela jonjic (HR))

27/02/2007
Stability of ketorolac tromethamine
Ketorolac tromethamine in dextrose 5% 100 ml polyolefin infusion bags may be frozen for 3 months and microwave thawed, without major changes that affect concentration. Ketorolac tromethamine solution may subsequently be stored at 4°C for up to 60 days.
Ann Pharmacother 2005; 39: 1654-1658.



23/02/2007
The Infostab website is now translated into  17 languages (russian has beenadded, translation performed by Violeta Kontrimaviciute)



20/02/2007
Stability of dexamethasone and ketamine
The mixtures of dexamethasone sodium phosphate (1 mg/14 ml) with ketamine hydrochloride (50 mg/14ml) in 0.9% sodium chloride were physically and chemically stable when stored in plastic syringes at 4°C, 23°C and 37°C and exposed to normal fluorescent light for 8 days.
Ref: J Pain Symptom Manage 2005; 30: 80-86.



16/02/2007
The Infostab website is now translated into  16 languages (lithuanian has been added, translation performed by Violeta Kontrimaviciute)



13/02/2007
Palonosetron stability
Palonosetron hydrochloride 25µg/ml (Aloxi®) is physically and chemically stable with lorazepam 0.25 mg/ml and midazolam HCl 1 mg/ml  in dextrose 5% during simulated Y-site injection.
Ref: Int J Pharm Compound 2005; 9, 3: 235-237.



09/02/2007
The Infostab website is now translated into  15 languages (hungarian has been , translation performed by Lívia Sáfrán)



06/02/2007
Stabilnost vorikonazola
The solution of voriconazole 4 mg/ml diluted in dextrose 5% in PVC bags is stable for at least 15 days at 4°C.
Ref: EJHP-S 2006; 12, 3: 57-59.



02/02/2007
Stability of frozen ceftriaxone
Ceftriaxone in 5% dextrose 100 ml polyolefin infusion bags may be frozen and microwave thawed by two different procedures at 270 Watts and 800 Watts power without major changes affecting concentration. Storage at 2°C to 8°C of solution did not affect the stability of the solution for at least 44 days for the 270 Watts cycle and 56 days for the 800 Watts cycle.
Ref: EJHP-S 2006; 13, 3: 52-56.



30/01/2007
A new link has been added in the databases towards "Syringe driver"


26/01/2007
Stability of morphine/hyoscine admixture used in palliative care.
The admixture morphine hydrochloride (1.37 mg/ml >> 10 mg/ml) with hyscine-Nbutyl bromide diluted with 0.9% sodium chloride is stable for 15 days in polypropylene syringes at room temperature or at 4°C and protected from light.
Ref: Support Care Cancer 2005; 13, 4: 239-245.



23/01/2007
Stability of prostaglandin E1 in aqueous solutions.
The stability of prostaglandin E1 in physiological serum (NaCl) was assessed considering different factors. Results showed that PGE1 was stable during three months, pH=7, whenstored at 4°C.
Ref: EJHP-S 2005; 11, 2: 31-36.


19/01/2007
Stability of doxorubicine and vincristine (VAD regimen)
The mixture doxorubicine 1.4 mg/ml with vincristine 0.053 mg/ml is stable in 0.9 sodium chloride or 0.45 sodium chloride/2.5% dextrose for at least 7 days when stored at 8°C. A new, sensitive LC-MS technique in combinaison with UV/fluorescence confirmed these results.
Ref: EJHP-S 2006; 1: 10-12.



16/01/2007
Compatibility irinotecan/ leucovorin
Rapid degradation of irinotecan was observed in one mixture: irinotecan 0,30mg/ml and leucovorin 3.6 mg/ml. The concentrations of irinotecan were  91.5% after 30 minutes and 76.3% after 24 hours. It was concluded that irinotecan and leucovorin were physically  compatible and chemically stable only for a sufficient period of time to allow concurrent infusion via a Y-site.
Ref: Can J Hosp Pharm 2005; 58, 4: 212-222.



09/01/2007
Incompatibility of mycafungin
Micafungin injection 1.5 mg/ml in 0.9% sodium chloride injection is physically incompatible for 4 hours after simulated Y-site co-administration at room temperature with albumin human, amiodarone, cisatracurium, diltiazem, dobutamine, epinephrine, insulin human regular, labetalol, meperidine, midazolam, morphine sulphate, mycophenolate mofetil, nesiritide, nicardipine, octreotide, ondansetron, phenytoin sodium, rocuronium bromide, vecuronium bromide.
Ref : Int J Pharm compound 2006; 10, 3: 230-232.


05/01/2007
Stability of palonosetron/dacarbazine admixture
Palonosetron HCl is physically and chemically stable when mixed with dacarbazine during simulated Y-site administration. However palonosetron HCl and methyl prednisolone sodium sucinate are physically incompatible, their admixture resulting in precipitation of methylprednisolone.
Ref : Int J Pharm Compound 2006; 10, 3: 234-236.



02/01/2007
Stability of frozen pemetrexed
Pemetrexed is chemically stable for 90 days frozen at -20°C, substantial numbers of microparticulates formes in pemetrexed diluted in the infusion dsolutions in PVC bags upon long-term frozen storage. The avoidance of freezing pemetrexed solutions in  PVC bag sis therefore warranted.
Ref : Ann Pharmacother 2006 ; 40, 7 : 1289-1292.



29/12/2006
Stability of pemetrexed
Pemetrexed 2, 10 and 20 mg/ml is chemically stable for 2 days at room temperature and
31 days refrigerated in dextrose 5% injection and NaCl 0.9% injection. However, substantial numbers of microparticulates may form in pemetrexed diluted in the infusion solutions in PVC bags, especially during longer periods of refrigerated storage.
Ref : Ann Pharmacother 2006 ; 40, 6 : 1082-1085.



26/12/2006
Incompatibility furosemide - phenylephrine
The solutions of furosemide 4 mg/ml diluted in 5% glucose 5% or 0.9% sodium chloride  are incompatible with the solutions of 0.64 mg/ml  phenylephrine and 0.4 UI/ml  vasopressine. This information is in contradiction with those of Trissel.
Ref : Am J Health Syst Pharm 2006 ; 63 : 906-908.



22/12/2006
The website is now translated into 14 languages (Latvian has been included) !

19/12/2006
A new link has been added in the databases towards "Trissel's Calcium & Phosphate Compatibility in Parenteral Nutrition"